Number of Protein Chains:3
- Classes: All alpha proteins
- Folds: Ras GEF
- Superfamilies: Ras GEF
- Families: Ras GEF
- Protein Domains: Son of sevenless protein homolog 1 (sos-1)
- Species: Human (Homo sapiens) [TaxId: 9606]
PDB Entries
PDB ID | OPM | Mutant | Chain Formula | Resolution | HETNAM | ||
---|---|---|---|---|---|---|---|
Amino Acid sequence | SCOPe Family Level | CATH Homology Level | |||||
1bkd | [A4B4] | [A4B4] | [A4B4] | 2.8 | |||
1nvu | [A2B] | [A2B] | [A2B] | 2.2 | GTP:GUANOSINE-5___sq___-TRIPHOSPHATE MG:MAGNESIUM ION PO4:PHOSPHATE ION | ||
1nvv | [ABC] | [A2B] | [A2B] | 2.18 | GNP:PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER MG:MAGNESIUM ION PO4:PHOSPHATE ION | ||
1nvw | [A2B] | [A2B] | [A2B] | 2.7 | GNP:PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER MG:MAGNESIUM ION PO4:PHOSPHATE ION | ||
1nvx | [A2B] | [A2B] | [A2B] | 3.2 | GTP:GUANOSINE-5___sq___-TRIPHOSPHATE MG:MAGNESIUM ION PO4:PHOSPHATE ION | ||
1xd2 | [ABC] | [A2B] | [A2B] | 2.7 | GDP:GUANOSINE-5___sq___-DIPHOSPHATE MG:MAGNESIUM ION PO4:PHOSPHATE ION | ||
1xd4 | [A] | [A] | [A] | 3.64 | |||
1xdv | [A] | [A] | [A] | 4.1 | |||
2ii0 | [A] | [A] | [A] | 2.02 | |||
4nyi | [ABC] | [A2B] | [A2B] | 2.96 | 2PX:N-{1-[(5-METHYL-1H-INDOL-3-YL)METHYL]PIPERIDIN-4-YL}-L-TRYPTOPHANAMIDE GNP:PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER MG:MAGNESIUM ION | ||
4nyj | [ABC] | [A2B] | [A2B] | 2.85 | 2PZ:N-[1-(1H-INDOL-3-YLMETHYL)PIPERIDIN-4-YL]GLYCINAMIDE GNP:PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER MG:MAGNESIUM ION | ||
5ovd | [A] | [A] | [A] | 1.9 | EDO:1,2-ETHANEDIOL | ||
5ove | [A] | [A] | [A] | 1.85 | AXE:6,7-DIMETHOXY-~{N}-[(1~{R})-1-NAPHTHALEN-1-YLETHYL]QUINAZOLIN-4-AMINE EDO:1,2-ETHANEDIOL | ||
5ovf | [A] | [A] | [A] | 2.01 | AWT:6,7-DIMETHOXY-2-METHYL-~{N}-[(1~{R})-1-[3-(1~{H}-PYRAZOL-4-YL)PHENYL]ETHYL]QUINAZOLIN-4-AMINE EDO:1,2-ETHANEDIOL | ||
5ovg | [A] | [A] | [A] | 2.3 | AWZ:~{N}-[(1~{R})-1-[5-(6,7-DIHYDRO-5~{H}-PYRROLO[1,2-A]IMIDAZOL-3-YL)THIOPHEN-2-YL]ETHYL]-6,7-DIMETHOXY-2-METHYL-QUINAZOLIN-4-AMINE EDO:1,2-ETHANEDIOL | ||
5ovh | [A] | [A] | [A] | 2.3 | AWW:[2-[5-[(1~{R})-1-[(6,7-DIMETHOXY-2-METHYL-5,8-DIHYDROQUINAZOLIN-4-YL)AMINO]ETHYL]THIOPHEN-2-YL]PHENYL]METHANOL EDO:1,2-ETHANEDIOL | ||
5ovi | [A] | [A] | [A] | 2.2 | AXH:6,7-DIMETHOXY-2-METHYL-~{N}-[(1~{R})-1-[4-[2-(METHYLAMINOMETHYL)PHENYL]THIOPHEN-2-YL]ETHYL]QUINAZOLIN-4-AMINE EDO:1,2-ETHANEDIOL | ||
5wfo | [A2B] | [A2B] | [A2B] | 1.99 | 5UU:6-CHLORANYL-~{N}-(4-FLUOROPHENYL)-1,2,3,4-TETRAHYDROACRIDIN-9-AMINE GNP:PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER MG:MAGNESIUM ION | ||
5wfp | [A2B] | [A2B] | [A2B] | 2.08 | 5UX:6-CHLORANYL-~{N}-(3-CHLORANYL-4-FLUORANYL-PHENYL)-1,2,3,4-TETRAHYDROACRIDIN-9-AMINE GNP:PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER MG:MAGNESIUM ION | ||
5wfq | [A2B] | [A2B] | [A2B] | 2.26 | 5UV:7-CHLORANYL-~{N}-(3-CHLORANYL-4-FLUORANYL-PHENYL)-1,2,3,4-TETRAHYDROACRIDIN-9-AMINE GNP:PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER MG:MAGNESIUM ION | ||
5wfr | [A2B] | [A2B] | [A2B] | 2.46 | 5UW:~{N}-(3,3-DIPHENYLPROPYL)PIPERIDIN-4-AMINE GNP:PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER MG:MAGNESIUM ION | ||
6bvi | [ABC] | [ABC] | [A2B] | 1.75 | CSO:S-HYDROXYCYSTEINE EC4:6-CHLORO-N-{1-[(5-CHLORO-1H-INDOL-3-YL)METHYL]PIPERIDIN-4-YL}-L-TRYPTOPHANAMIDE FMT:FORMIC ACID GNP:PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER GOL:GLYCEROL MG:MAGNESIUM ION NA:SODIUM ION | ||
6bvj | [ABC] | [ABC] | [A2B] | 1.75 | CSO:S-HYDROXYCYSTEINE EAS:5-CHLORO-N-{1-[(5-CHLORO-1H-INDOL-3-YL)METHYL]PIPERIDIN-4-YL}-L-TRYPTOPHANAMIDE FMT:FORMIC ACID GNP:PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER GOL:GLYCEROL MG:MAGNESIUM ION NA:SODIUM ION | ||
6bvk | [ABC] | [ABC] | [A2B] | 1.8 | CSO:S-HYDROXYCYSTEINE EAV:N-{1-[(5-CHLORO-1H-INDOL-3-YL)METHYL]PIPERIDIN-4-YL}-6-METHYL-L-TRYPTOPHANAMIDE FMT:FORMIC ACID GNP:PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER GOL:GLYCEROL MG:MAGNESIUM ION NA:SODIUM ION | ||
6bvl | [ABC] | [ABC] | [A2B] | 1.75 | CSO:S-HYDROXYCYSTEINE EBY:N-{1-[(5-CHLORO-1H-INDOL-3-YL)METHYL]PIPERIDIN-4-YL}-5-METHYL-L-TRYPTOPHANAMIDE FMT:FORMIC ACID GNP:PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER GOL:GLYCEROL MG:MAGNESIUM ION NA:SODIUM ION | ||
6bvm | [ABC] | [ABC] | [A2B] | 1.8 | CSO:S-HYDROXYCYSTEINE EBV:(2S)-2-AMINO-1-[(3AR,6AS)-5-[(5-CHLORO-1H-INDOL-3-YL)METHYL]HEXAHYDROPYRROLO[3,4-C]PYRROL-2(1H)-YL]-3-(1H-INDOL-3-YL)PROPAN-1-ONE FMT:FORMIC ACID GNP:PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER GOL:GLYCEROL MG:MAGNESIUM ION NA:SODIUM ION | ||
6cuo | [ABC] | [ABC] | [A2B] | 1.73 | CSO:S-HYDROXYCYSTEINE FFS:N~2~-(3-CHLOROPHENYL)-N~4~-[(FURAN-2-YL)METHYL]QUINAZOLINE-2,4-DIAMINE FMT:FORMIC ACID GNP:PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER GOL:GLYCEROL MG:MAGNESIUM ION NA:SODIUM ION | ||
6cup | [ABC] | [ABC] | [A2B] | 1.83 | CSO:S-HYDROXYCYSTEINE FFV:N~2~-(3-CHLORO-4-FLUOROPHENYL)-N~4~-[(1R)-1-CYCLOPROPYLETHYL]QUINAZOLINE-2,4-DIAMINE FMT:FORMIC ACID GNP:PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER GOL:GLYCEROL MG:MAGNESIUM ION NA:SODIUM ION | ||
6cur | [ABC] | [ABC] | [A2B] | 1.73 | CSO:S-HYDROXYCYSTEINE FFY:N~2~-(3-CHLORO-4-FLUOROPHENYL)-N~4~-[(1R)-1-CYCLOPROPYLETHYL]-8-(1,2,3,6-TETRAHYDROPYRIDIN-4-YL)QUINAZOLINE-2,4-DIAMINE FMT:FORMIC ACID GNP:PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER GOL:GLYCEROL MG:MAGNESIUM ION NA:SODIUM ION | ||
6d55 | [ABC] | [ABC] | [A2B] | 1.68 | CSO:S-HYDROXYCYSTEINE FMT:FORMIC ACID FWA:6-CHLORO-2-(2,6-DIAZASPIRO[3.3]HEPTAN-2-YL)-1-[(4-FLUORO-3,5-DIMETHYLPHENYL)METHYL]-4-(4-METHYLPIPERAZIN-1-YL)-1H-BENZIMIDAZOLE GNP:PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER GOL:GLYCEROL MG:MAGNESIUM ION NA:SODIUM ION | ||
6d56 | [ABC] | [ABC] | [A2B] | 1.68 | CSO:S-HYDROXYCYSTEINE FMT:FORMIC ACID FVM:6-CHLORO-2-(2,6-DIAZASPIRO[3.3]HEPTAN-2-YL)-4-(3,5-DIMETHYL-1H-PYRAZOL-4-YL)-1-[(4-FLUORO-3,5-DIMETHYLPHENYL)METHYL]-1H-BENZIMIDAZOLE GNP:PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER GOL:GLYCEROL MG:MAGNESIUM ION NA:SODIUM ION | ||
6d59 | [ABC] | [ABC] | [A2B] | 1.7 | CSO:S-HYDROXYCYSTEINE FMT:FORMIC ACID FVJ:6-CHLORO-4-(3,5-DIMETHYL-1H-PYRAZOL-4-YL)-1-[(4-FLUORO-3,5-DIMETHYLPHENYL)METHYL]-2-(PIPERAZIN-1-YL)-1H-BENZIMIDAZOLE GNP:PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER GOL:GLYCEROL MG:MAGNESIUM ION NA:SODIUM ION | ||
6d5e | [ABC] | [ABC] | [A2B] | 1.75 | CL:CHLORIDE ION CSO:S-HYDROXYCYSTEINE FMT:FORMIC ACID FVG:1-[(2S)-1-{6-CHLORO-1-[(4-FLUORO-3,5-DIMETHYLPHENYL)METHYL]-2-(PIPERAZIN-1-YL)-1H-BENZIMIDAZOL-4-YL}PYRROLIDIN-2-YL]METHANAMINE GNP:PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER GOL:GLYCEROL MG:MAGNESIUM ION NA:SODIUM ION | ||
6d5g | [ABC] | [ABC] | [A2B] | 1.92 | BME:BETA-MERCAPTOETHANOL CL:CHLORIDE ION CSO:S-HYDROXYCYSTEINE FMT:FORMIC ACID FVD:6-CHLORO-1-[(4-FLUORO-3,5-DIMETHYLPHENYL)METHYL]-2-(PIPERAZIN-1-YL)-4-(1,2,3,6-TETRAHYDROPYRIDIN-4-YL)-1H-BENZIMIDAZOLE GNP:PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER GOL:GLYCEROL MG:MAGNESIUM ION | ||
6d5h | [ABC] | [ABC] | [A2B] | 1.8 | CL:CHLORIDE ION CSO:S-HYDROXYCYSTEINE FMT:FORMIC ACID FV7:6-CHLORO-4-(2-CHLOROPHENYL)-1-[(4-FLUORO-3,5-DIMETHYLPHENYL)METHYL]-2-(PIPERAZIN-1-YL)-1H-BENZIMIDAZOLE GNP:PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER GOL:GLYCEROL MG:MAGNESIUM ION | ||
6d5j | [ABC] | [ABC] | [A2B] | 1.75 | CSO:S-HYDROXYCYSTEINE FMT:FORMIC ACID FV4:6-CHLORO-1-[(4-FLUORO-3,5-DIMETHYLPHENYL)METHYL]-2-(PIPERAZIN-1-YL)-1H-BENZIMIDAZOLE GNP:PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER GOL:GLYCEROL MG:MAGNESIUM ION NA:SODIUM ION | ||
6d5l | [ABC] | [ABC] | [A2B] | 1.7 | CSO:S-HYDROXYCYSTEINE FMT:FORMIC ACID FW7:6-CHLORO-1-[(3-CHLORO-4-FLUOROPHENYL)METHYL]-2-(PIPERAZIN-1-YL)-1H-BENZIMIDAZOLE GNP:PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER GOL:GLYCEROL MG:MAGNESIUM ION NA:SODIUM ION | ||
6d5m | [ABC] | [ABC] | [A2B] | 2.08 | FW4:1-[(3-CHLORO-4-FLUOROPHENYL)METHYL]-5,6-DIMETHYL-2-(PIPERAZIN-1-YL)-1H-BENZIMIDAZOLE GNP:PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER MG:MAGNESIUM ION | ||
6d5v | [ABC] | [ABC] | [A2B] | 2.04 | FVY:1-[(3-CHLORO-4-FLUOROPHENYL)METHYL]-5,6-DIMETHYL-1H-BENZIMIDAZOL-2-AMINE GNP:PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER MG:MAGNESIUM ION | ||
6d5w | [ABC] | [A2B] | [A2B] | 2.48 | FVV:10-[(4-FLUOROPHENYL)METHYL]-2,3,4,10-TETRAHYDROPYRIMIDO[1,2-A]BENZIMIDAZOLE GNP:PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER MG:MAGNESIUM ION | ||
6epl | [AB] | [AB] | [AB] | 2.55 | GOL:GLYCEROL | ||
6epm | [AB] | [AB] | [AB] | 2.5 | BQ5:(1-PHENYL-5,6-DIHYDRO-4~{H}-CYCLOPENTA[C]PYRAZOL-3-YL)METHANAMINE GOL:GLYCEROL | ||
6epn | [AB] | [AB] | [AB] | 2.5 | BQ2:1-(3,4-DIHYDRO-1~{H}-ISOQUINOLIN-2-YL)-2-OXIDANYL-ETHANONE DMS:DIMETHYL SULFOXIDE GOL:GLYCEROL | ||
6epo | [AB] | [AB] | [AB] | 2.4 | BPW:3-(4-CHLOROPHENYL)PROPAN-1-AMINE GOL:GLYCEROL | ||
6epp | [AB] | [AB] | [AB] | 2.4 | BOQ:ETHYL 2-(AMINOMETHYL)-5-~{TERT}-BUTYL-FURAN-3-CARBOXYLATE GOL:GLYCEROL | ||
6scm | [A] | [A] | [A] | 1.87 | EDO:1,2-ETHANEDIOL IMD:IMIDAZOLE L7H:~{N}-[(1~{R})-1-[3-AZANYL-5-(TRIFLUOROMETHYL)PHENYL]ETHYL]-7-METHOXY-2-METHYL-6-[(3~{S})-OXOLAN-3-YL]OXY-QUINAZOLIN-4-AMINE | ||
6sfr | [A] | [A] | [A] | 1.92 | IMD:IMIDAZOLE LBK:6,7-DIMETHOXY-~{N}-[(1~{R})-1-PHENYLETHYL]QUINAZOLIN-4-AMINE | ||
6v94 | [ABC] | [ABC] | [ABC] | 1.8 | CSO:S-HYDROXYCYSTEINE FMT:FORMIC ACID GNP:PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER GOL:GLYCEROL MG:MAGNESIUM ION NA:SODIUM ION QTV:1-[(4-FLUOROPHENYL)METHYL]-2-METHYL-4-NITRO-1H-IMIDAZOLE | ||
6v9f | [ABC] | [ABC] | [ABC] | 1.85 | CSO:S-HYDROXYCYSTEINE FMT:FORMIC ACID GNP:PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER GOL:GLYCEROL MG:MAGNESIUM ION NA:SODIUM ION QTS:1-[(4-CHLOROPHENYL)METHYL]-1H-BENZIMIDAZOL-2-AMINE | ||
6v9j | [ABC] | [ABC] | [ABC] | 1.76 | CSO:S-HYDROXYCYSTEINE FMT:FORMIC ACID GNP:PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER GOL:GLYCEROL MG:MAGNESIUM ION NA:SODIUM ION QTM:3-(2-AMINOETHYL)-4-(3-CHLORO-4-FLUOROPHENOXY)BENZENE-1-SULFONAMIDE | ||
6v9l | [ABC] | [ABC] | [ABC] | 1.7 | ACT:ACETATE ION CSO:S-HYDROXYCYSTEINE FMT:FORMIC ACID GNP:PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER GOL:GLYCEROL MG:MAGNESIUM ION NA:SODIUM ION QTJ:4-(3-CHLORO-4-FLUOROPHENOXY)BENZENE-1-SULFONAMIDE | ||
6v9m | [ABC] | [ABC] | [ABC] | 1.65 | CSO:S-HYDROXYCYSTEINE FMT:FORMIC ACID GNP:PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER GOL:GLYCEROL MG:MAGNESIUM ION NA:SODIUM ION QTG:4-FLUORO-2-METHYL-N-PROPYLBENZENE-1-SULFONAMIDE | ||
6v9n | [ABC] | [ABC] | [ABC] | 1.65 | CSO:S-HYDROXYCYSTEINE FMT:FORMIC ACID GNP:PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER GOL:GLYCEROL MG:MAGNESIUM ION NA:SODIUM ION QTD:4-PHENOXYBENZENE-1-SULFONAMIDE | ||
6v9o | [ABC] | [ABC] | [ABC] | 1.8 | CSO:S-HYDROXYCYSTEINE FMT:FORMIC ACID GNP:PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER GOL:GLYCEROL MG:MAGNESIUM ION NA:SODIUM ION QTA:3-(PHENYLSULFONYL)BENZENE-1-SULFONAMIDE | ||
7avi | [A] | [A] | [A] | 1.93 | S2Q:3-PROPAN-2-YL-~{N}-[(1~{R})-1-(3-SULFAMOYLPHENYL)ETHYL]-[1,2]OXAZOLO[5,4-B]PYRIDINE-5-CARBOXAMIDE | ||
7avl | [A] | [A] | [A] | 1.72 | IMD:IMIDAZOLE S2Z:6,7-DIMETHOXY-2-METHYL-~{N}-[(1~{R})-1-PHENYLETHYL]QUINAZOLIN-4-AMINE | ||
7avs | [A] | [A] | [A] | 2.28 | IMD:IMIDAZOLE S3Q:6,7-DIMETHOXY-2-METHYL-~{N}-[(1~{R})-1-[3-(TRIFLUOROMETHYL)PHENYL]ETHYL]QUINAZOLIN-4-AMINE | ||
7avt | [A] | [A] | [A] | 1.88 | IMD:IMIDAZOLE S3T:~{N}-[(1~{R})-1-(3-AMINOPHENYL)ETHYL]-6,7-DIMETHOXY-2-METHYL-QUINAZOLIN-4-AMINE | ||
7avu | [A] | [A] | [A] | 2.1 | IMD:IMIDAZOLE S3Z:~{N}-[(1~{R})-1-[3-AZANYL-5-(TRIFLUOROMETHYL)PHENYL]ETHYL]-6,7-DIMETHOXY-2-METHYL-QUINAZOLIN-4-AMINE | ||
7avv | [A] | [A] | [A] | 2.12 | IMD:IMIDAZOLE S2W:~{N}-[(1~{R})-1-[3-AZANYL-5-(TRIFLUOROMETHYL)PHENYL]ETHYL]-2-METHYL-QUINAZOLIN-4-AMINE |
*Chain Formula of OLIGAMI.
[ ] : Polypeptide - [AB] : Protein, [ab] : Small peptide
( ) : Nucleic acid - (AB) : DNA, (ab) : RNA
[ ] : Polypeptide - [AB] : Protein, [ab] : Small peptide
( ) : Nucleic acid - (AB) : DNA, (ab) : RNA