Number of Protein Chains:6
- Classes: Membrane and cell surface proteins and peptides
- Folds: Toxins' membrane translocation domains
- Superfamilies: Bcl-2 inhibitors of programmed cell death
- Families: Bcl-2 inhibitors of programmed cell death
- Protein Domains: Apoptosis regulator Bcl-xL
- Species: Human (Homo sapiens) [TaxId: 9606]
PDB Entries
PDB ID | OPM | Mutant | Chain Formula | Resolution | HETNAM | ||
---|---|---|---|---|---|---|---|
Amino Acid sequence | SCOPe Family Level | CATH Homology Level | |||||
1bxl | [A][a] | [A][a] | [A][a] | SOLUTION NMR |
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1g5j | [A][a] | [A][a] | [A][a] | SOLUTION NMR |
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1lxl | [A] | [A] | [A] | SOLUTION NMR |
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1maz | [A] | [A] | [A] | 2.2 | |||
1r2d | [A] | [A] | [A] | 1.95 | |||
1r2e | [A] | [A] | [A] | 2.1 | |||
1r2g | [A] | [A] | [A] | 2.7 | |||
1r2h | [A] | [A] | [A] | 2.2 | |||
1r2i | [A] | [A] | [A] | 2 | |||
1ysg | [A] | [A] | [A] | SOLUTION NMR |
4FC:4___sq___-FLUORO-1,1___sq___-BIPHENYL-4-CARBOXYLIC ACID TN1:5,6,7,8-TETRAHYDRONAPHTHALEN-1-OL | ||
1ysi | [A] | [A] | [A] | SOLUTION NMR |
N3B:N-[(4___sq___-FLUORO-1,1___sq___-BIPHENYL-4-YL)CARBONYL]-3-NITRO-4-{[2-(PHENYLSULFANYL)ETHYL]AMINO}BENZENESULFONAMIDE | ||
1ysn | [A] | [A] | [A] | SOLUTION NMR |
43B:3-NITRO-N-{4-[2-(2-PHENYLETHYL)-1,3-BENZOTHIAZOL-5-YL]BENZOYL}-4-{[2-(PHENYLSULFANYL)ETHYL]AMINO}BENZENESULFONAMIDE | ||
2b48 | [A2] | [A2] | [A2] | 3.45 | |||
2lpc | [A] | [A] | [A] | SOLUTION NMR |
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2me8 | [A] | [A] | [A] | SOLUTION NMR |
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2me9 | [A] | [A] | [A] | SOLUTION NMR |
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2o1y | [A] | [A] | [A] | SOLUTION NMR |
43B:3-NITRO-N-{4-[2-(2-PHENYLETHYL)-1,3-BENZOTHIAZOL-5-YL]BENZOYL}-4-{[2-(PHENYLSULFANYL)ETHYL]AMINO}BENZENESULFONAMIDE | ||
2o2m | [A] | [A] | [A] | SOLUTION NMR |
LI0:4-(4-BENZYL-4-METHOXYPIPERIDIN-1-YL)-N-[(4-{[1,1-DIMETHYL-2-(PHENYLTHIO)ETHYL]AMINO}-3-NITROPHENYL)SULFONYL]BENZAMIDE | ||
2o2n | [A] | [A] | [A] | SOLUTION NMR |
LIW:4-[4-(BIPHENYL-2-YLMETHYL)PIPERAZIN-1-YL]-N-[(4-{[1,1-DIMETHYL-2-(PHENYLTHIO)ETHYL]AMINO}-3-NITROPHENYL)SULFONYL]BENZAMIDE | ||
2p1l | [AB] | [AB] | [AB] | 2.5 | |||
2pon | [A][a] | [A][a] | [A][a] | SOLUTION NMR |
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2yxj | [A] | [A] | [A] | 2.2 | CL:CHLORIDE ION GOL:GLYCEROL N3C:4-{4-[(4___sq___-CHLOROBIPHENYL-2-YL)METHYL]PIPERAZIN-1-YL}-N-{[4-({(1R)-3-(DIMETHYLAMINO)-1-[(PHENYLTHIO)METHYL]PROPYL}AMINO)-3-NITROPHENYL]SULFONYL}BENZAMIDE | ||
3cva | [A] | [A] | [A] | 2.7 | |||
3io8 | [A][a] | [A][a] | [A][a] | 2.3 | ZN:ZINC ION | ||
3pl7 | [AB] | [AB] | [AB] | 2.61 | |||
3qkd | [A] | [A] | [A] | 2.02 | CL:CHLORIDE ION GOL:GLYCEROL HI0:(R)-N-(7-(4-((4___sq___-CHLOROBIPHENYL-2-YL)METHYL)PIPERAZIN-1-YL)QUINAZOLIN-4-YL)-4-(4-(DIMETHYLAMINO)-1-(PHENYLTHIO)BUTAN-2-YLAMINO)-3-NITROBENZENESULFONAMIDE | ||
3sp7 | [A] | [A] | [A] | 1.4 | 03B:5-(4-CHLOROPHENYL)-4-{3-[4-(4-{[(4-{[(2R)-4-(DIMETHYLAMINO)-1-(PHENYLSULFANYL)BUTAN-2-YL]AMINO}-3-NITROPHENYL)SULFONYL]AMINO}PHENYL)PIPERAZIN-1-YL]PHENYL}-1,2-DIMETHYL-1H-PYRROLE-3-CARBOXYLIC ACID ACT:ACETATE ION ZN:ZINC ION | ||
3spf | [A] | [A] | [A] | 1.7 | B50:4-(4-CHLOROPHENYL)-1-[(3S)-3,4-DIHYDROXYBUTYL]-N-[3-(4-METHYLPIPERAZIN-1-YL)PROPYL]-3-PHENYL-1H-PYRROLE-2-CARBOXAMIDE GOL:GLYCEROL | ||
3wiz | [A2] | [A2] | [A2] | 2.45 | LC6:7-(4-{[(4-{[(2R)-4-(DIMETHYLAMINO)-1-(PHENYLSULFANYL)BUTAN-2-YL]AMINO}-3-NITROPHENYL)SULFONYL]CARBAMOYL}-2-METHYLPHENYL)-3-[3-(NAPHTHALEN-1-YLOXY)PROPYL]PYRAZOLO[1,5-A]PYRIDINE-2-CARBOXYLIC ACID PO4:PHOSPHATE ION | ||
4ehr | [A] | [A] | [A] | 2.09 | 0Q5:4-[5-BUTYL-3-(HYDROXYMETHYL)-1-PHENYL-1H-PYRAZOL-4-YL]-3-(3,4-DIHYDROISOQUINOLIN-2(1H)-YLCARBONYL)-N-{[2-(TRIMETHYLSILYL)ETHYL]SULFONYL}BENZAMIDE IMD:IMIDAZOLE | ||
4ppi | [A6] | [A6] | [A6] | 2.85 | GOL:GLYCEROL | ||
4qvx | [A2] | [A2] | [A2] | 2.1 | 3CQ:2-[8-(1,3-BENZOTHIAZOL-2-YLCARBAMOYL)-3,4-DIHYDROISOQUINOLIN-2(1H)-YL]-5-(3-{4-[3-(DIMETHYLAMINO)PROP-1-YN-1-YL]-2-FLUOROPHENOXY}PROPYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID | ||
4tuh | [A2] | [A2] | [A2] | 1.8 | 38H:2-[8-(1,3-BENZOTHIAZOL-2-YLCARBAMOYL)-3,4-DIHYDROISOQUINOLIN-2(1H)-YL]-5-{3-[4-(1H-PYRAZOLO[3,4-D]PYRIMIDIN-1-YL)PHENOXY]PROPYL}-1,3-THIAZOLE-4-CARBOXYLIC ACID ACT:ACETATE ION EDO:1,2-ETHANEDIOL | ||
4z9v | [A2][a6] | [A2][a6] | [A2][a6] | 2.1 | BCT:BICARBONATE ION NA:SODIUM ION | ||
5b1z | [A2][a2] | [A2][a2] | [A2][a2] | 2.15 | |||
6bf2 | [A] | [A] | [A] | SOLUTION NMR |
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6qgg | [A] | [A] | [A] | 1.5 | J1H:[(3~{R})-3-[[4-[[4-[4-[[2-(4-CHLOROPHENYL)PHENYL]METHYL]PIPERAZIN-1-YL]PHENYL]CARBONYLSULFAMOYL]-2-NITRO-PHENYL]AMINO]-4-PHENYLSULFANYL-BUTYL]-(2-HYDROXY-2-OXOETHYL)-DIMETHYL-AZANIUM | ||
6qgh | [A] | [A] | [A] | 2 | 1XJ:4-(4-{[2-(4-CHLOROPHENYL)-5,5-DIMETHYLCYCLOHEX-1-EN-1-YL]METHYL}PIPERAZIN-1-YL)-N-[(4-{[(2R)-4-(MORPHOLIN-4-YL)-1-(PHENYLSULFANYL)BUTAN-2-YL]AMINO}-3-[(TRIFLUOROMETHYL)SULFONYL]PHENYL)SULFONYL]BENZAMIDE | ||
6qgj | [A] | [A] | [A] | 1.9 | J1T:4-[4-[(1~{R})-1-(6-METHOXY-1,3-BENZODIOXOL-5-YL)-2-PYRROLIDIN-1-YL-ETHYL]PHENYL]-~{N}-[4-[[(2~{R})-4-MORPHOLIN-4-YL-1-PHENYLSULFANYL-BUTAN-2-YL]AMINO]-3-(TRIFLUOROMETHYLSULFONYL)PHENYL]SULFONYL-BENZAMIDE | ||
6qgk | [A] | [A] | [A] | 1.8 | ACT:ACETATE ION J1Q:1-[2-[[(3~{S})-3-(AMINOMETHYL)-3,4-DIHYDRO-1~{H}-ISOQUINOLIN-2-YL]CARBONYL]PHENYL]-~{N},~{N}-DIBUTYL-5-METHYL-PYRAZOLE-3-CARBOXAMIDE | ||
6rnu | [A2] | [A2] | [A2] | 2.4 | BR:BROMIDE ION KBH:4-(4-FLUOROPHENYL)-3-FLUOROSULFONYL-BENZOIC ACID | ||
6uvc | [A2] | [A2] | [A2] | 1.9 | EDO:1,2-ETHANEDIOL SO4:SULFATE ION XOY:(R)-3-(BENZYLTHIO)-2-(3-(2-((4___sq___-CHLORO-[1,1___sq___-BIPHENYL]-2-YL)METHYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBONYL)-3-(4-METHYLBENZYL)UREIDO)PROPANOIC ACID | ||
6uvd | [A2] | [A2] | [A2] | 2.15 | EDO:1,2-ETHANEDIOL SO4:SULFATE ION XOU:(2R)-3-(BENZYLSULFANYL)-2-({[(4-METHYLPHENYL)METHYL][(4 PHENYLPHENYL)CARBONYL] CARBAMOYL}AMINO) PROPANOICACID | ||
6uve | [A2] | [A2] | [A2] | 2.87 | EDO:1,2-ETHANEDIOL QHV:(R)-3-(BENZYLTHIO)-2-(3-(4-CHLORO-[1,1___sq___:2___sq___,1___sq______sq___:3___sq______sq___,1___sq______sq______sq___-QUATERPHENYL]-4___sq______sq______sq___-CARBONYL)-3-(4-METHYLBENZYL)UREIDO)PROPANOIC ACID | ||
6uvf | [A2] | [A2] | [A2] | 2.24 | EDO:1,2-ETHANEDIOL QHS:(R)-2-(3-([1,1___sq___-BIPHENYL]-4-CARBONYL)-3-(4-METHYLBENZYL)UREIDO)-3-((CYCLOHEXYLMETHYL)SULFONYL)PROPANOIC ACID SO4:SULFATE ION | ||
6uvg | [A2] | [A2] | [A2] | 2.1 | EDO:1,2-ETHANEDIOL QHP:(R)-2-(3-([1,1___sq___-BIPHENYL]-4-CARBONYL)-3-(4-METHYLBENZYL)UREIDO)-3-(((3R,5R,7R)-ADAMANTAN-1-YLMETHYL)SULFONYL)PROPANOIC ACID SO4:SULFATE ION | ||
6uvh | [A2] | [A2] | [A2] | 2.19 | EDO:1,2-ETHANEDIOL QHJ:(R)-2-(3-(2-((4___sq___-CHLORO-[1,1___sq___-BIPHENYL]-2-YL)METHYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBONYL)-3-(4-METHYLBENZYL)UREIDO)-3-((CYCLOHEXYLMETHYL)SULFONYL)PROPANOIC ACID SO4:SULFATE ION | ||
6vwc | [A] | [A] | [A] | 1.6 | RQ7:6-{8-[(1,3-BENZOTHIAZOL-2-YL)CARBAMOYL]-3,4-DIHYDROISOQUINOLIN-2(1H)-YL}-3-{1-[(PYRIDIN-4-YL)METHYL]-1H-PYRAZOL-4-YL}PYRIDINE-2-CARBOXYLIC ACID | ||
7jgv | [A2] | [A2] | [A2] | 2.05 | V9S:6-[(8E)-8-{2-[4-(BENZYLCARBAMOYL)-1,3-THIAZOL-2-YL]HYDRAZINYLIDENE}-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL]-3-(2-PHENYLETHOXY)PYRIDINE-2-CARBOXYLIC ACID | ||
7jgw | [A2] | [A2] | [A2] | 1.3 | V9S:6-[(8E)-8-{2-[4-(BENZYLCARBAMOYL)-1,3-THIAZOL-2-YL]HYDRAZINYLIDENE}-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL]-3-(2-PHENYLETHOXY)PYRIDINE-2-CARBOXYLIC ACID | ||
7lh7 | [A] | [A] | [A] | 1.41 | XZM:N-(1,3-BENZOTHIAZOL-2-YL)-2-(4-{[(4-{[(2R)-4-(MORPHOLIN-4-YL)-1-(PHENYLSULFANYL)BUTAN-2-YL]AMINO}-3-[(TRIFLUOROMETHYL)SULFONYL]PHENYL)SULFONYL]CARBAMOYL}-1,3-THIAZOL-2-YL)-1,2,3,4-TETRAHYDROISOQUINOLINE-8-CARBOXAMIDE |
*Chain Formula of OLIGAMI.
[ ] : Polypeptide - [AB] : Protein, [ab] : Small peptide
( ) : Nucleic acid - (AB) : DNA, (ab) : RNA
[ ] : Polypeptide - [AB] : Protein, [ab] : Small peptide
( ) : Nucleic acid - (AB) : DNA, (ab) : RNA