[A6]
- Classes: Alpha and beta proteins (a+b)
- Folds: Zincin-like
- Superfamilies: Metalloproteases ('zincins'), catalytic domain
- Families: Matrix metalloproteases, catalytic domain
- Protein Domains: Macrophage elastase (MMP-12)
- Species: Human (Homo sapiens) [TaxId: 9606]
PDB Entries
PDB ID | OPM | Mutant | Chain Formula | Resolution | HETNAM | ||
---|---|---|---|---|---|---|---|
Amino Acid sequence | SCOPe Family Level | CATH Homology Level | |||||
1jiz | [A] | [A] | [A] | 2.6 | CA:CALCIUM ION CGS:N-HYDROXY-2(R)-[[(4-METHOXYPHENYL)SULFONYL](3-PICOLYL)AMINO]-3-METHYLBUTANAMIDE HYDROCHLORIDE ZN:ZINC ION | ||
1jk3 | [A] | [A] | [A] | 1.09 | BAT:4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE CA:CALCIUM ION ZN:ZINC ION | ||
1os2 | [A] | [A] | [A] | 2.15 | ACT:ACETATE ION AZI:AZIDE ION CA:CALCIUM ION HAE:ACETOHYDROXAMIC ACID ZN:ZINC ION | ||
1os9 | [A] | [A] | [A] | 1.85 | CA:CALCIUM ION ZN:ZINC ION | ||
1rmz | [A] | [A] | [A] | 1.34 | CA:CALCIUM ION NGH:N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMICACID ZN:ZINC ION | ||
1ros | [A] | [A] | [A] | 2 | CA:CALCIUM ION DEO:2-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHYL]-4-(4___sq___-ETHOXY-1,1___sq___-BIPHENYL-4-YL)-4-OXOBUTANOIC ACID ZN:ZINC ION | ||
1utt | [A6] | [A6] | [A6] | 2.2 | CA:CALCIUM ION CP8:2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL) ETHYL-4-(4___sq___-ETHOXY [1,1___sq___-BIPHENYL]-4-YL)-4-OXOBUTANOIC ACID HAE:ACETOHYDROXAMIC ACID ZN:ZINC ION | ||
1utz | [A6] | [A6] | [A6] | 2.5 | CA:CALCIUM ION HAE:ACETOHYDROXAMIC ACID PF3:(2R)-3-({[4-[(PYRIDIN-4-YL)PHENYL]-THIEN-2-YL}CARBOXAMIDO)(PHENYL)PROPANOIC ACID ZN:ZINC ION | ||
1y93 | [A] | [A] | [A] | 1.03 | CA:CALCIUM ION HAE:ACETOHYDROXAMIC ACID ZN:ZINC ION | ||
1ycm | [A] | [A] | [A] | SOLUTION NMR |
CA:CALCIUM ION NGH:N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMICACID ZN:ZINC ION | ||
2hu6 | [A] | [A] | [A] | 1.32 | 37A:(1S,5S,7R)-N~7~-(BIPHENYL-4-YLMETHYL)-N~3~-HYDROXY-6,8-DIOXA-3-AZABICYCLO[3.2.1]OCTANE-3,7-DICARBOXAMIDE CA:CALCIUM ION HAE:ACETOHYDROXAMIC ACID ZN:ZINC ION | ||
2k2g | [A] | [A] | [A] | SOLUTION NMR |
DSV:N-(DIBENZO[B,D]THIOPHEN-3-YLSULFONYL)-L-VALINE ZN:ZINC ION | ||
2k9c | [A] | [A] | [A] | SOLUTION NMR |
CO:COBALT (II) ION | ||
2mlr | [A] | [A] | [A] | SOLUTION NMR |
CA:CALCIUM ION PX4:1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE ZN:ZINC ION | ||
2mls | [A] | [A] | [A] | SOLUTION NMR |
CA:CALCIUM ION PX4:1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE ZN:ZINC ION | ||
2n8r | [A3B] | [A3B] | [A3B] | SOLUTION NMR |
CA:CALCIUM ION HYP:4-HYDROXYPROLINE ZN:ZINC ION | ||
2oxu | [A] | [A] | [A] | 1.24 | CA:CALCIUM ION ZN:ZINC ION | ||
2oxw | [A][a] | [A][a] | [A][a] | 1.15 | CA:CALCIUM ION ZN:ZINC ION | ||
2oxz | [A][ab] | [A][ab] | [A][ab] | 1.9 | CA:CALCIUM ION ZN:ZINC ION | ||
2poj | [A] | [A] | [A] | SOLUTION NMR |
CA:CALCIUM ION ZN:ZINC ION | ||
2wo8 | [A] | [A] | [A] | 2 | 023:N^2^-[(2R)-2-{(1S)-1-[FORMYL(HYDROXY)AMINO]ETHYL}-5-PHENYLPENTANOYL]-N,3-DIMETHYL-L-VALINAMIDE 077:(3S)-5-BIPHENYL-4-YL-3-HYDROXYPENTANOIC ACID CA:CALCIUM ION GOL:GLYCEROL SO4:SULFATE ION ZN:ZINC ION | ||
2wo9 | [A] | [A] | [A] | 1.7 | 023:N^2^-[(2R)-2-{(1S)-1-[FORMYL(HYDROXY)AMINO]ETHYL}-5-PHENYLPENTANOYL]-N,3-DIMETHYL-L-VALINAMIDE 068:(3S)-5-(4___sq___-ACETYLBIPHENYL-4-YL)-3-HYDROXYPENTANOIC ACID CA:CALCIUM ION GOL:GLYCEROL SO4:SULFATE ION ZN:ZINC ION | ||
2woa | [A] | [A] | [A] | 2.26 | 023:N^2^-[(2R)-2-{(1S)-1-[FORMYL(HYDROXY)AMINO]ETHYL}-5-PHENYLPENTANOYL]-N,3-DIMETHYL-L-VALINAMIDE 576:(3S)-5-(9H-FLUOREN-2-YL)-3-HYDROXYPENTANOICACID CA:CALCIUM ION GOL:GLYCEROL SO4:SULFATE ION ZN:ZINC ION | ||
2z2d | [A] | [A] | [A] | SOLUTION NMR |
CA:CALCIUM ION HSI:(3R)-3-{4-[(4-CHLOROPHENYL)ETHYNYL]BENZOYL}NONANOICACID ZN:ZINC ION | ||
3ba0 | [A] | [A] | [A] | 3 | CA:CALCIUM ION HAE:ACETOHYDROXAMIC ACID ZN:ZINC ION | ||
3ehx | [A] | [A] | [A] | 1.9 | BDL:N-(BIPHENYL-4-YLSULFONYL)-D-LEUCINE CA:CALCIUM ION ZN:ZINC ION | ||
3ehy | [A] | [A] | [A] | 1.9 | CA:CALCIUM ION TBL:N-[(4-METHOXYPHENYL)SULFONYL]-D-ALANINE ZN:ZINC ION | ||
3lik | [A] | [A] | [A] | 1.8 | CA:CALCIUM ION EEG:N-{3-[4-(4-PHENYLTHIOPHEN-2-YL)PHENYL]PROPANOYL}-L-ALPHA-GLUTAMYL-L-ALPHA-GLUTAMYL-AMIDE HAE:ACETOHYDROXAMIC ACID P6G:HEXAETHYLENE GLYCOL ZN:ZINC ION | ||
3lil | [A] | [A] | [A] | 1.8 | CA:CALCIUM ION EEA:N-{3-[3-(3___sq___-CHLOROBIPHENYL-4-YL)ISOXAZOL-5-YL]PROPANOYL}-L-ALPHA-GLUTAMYL-L-ALPHA-GLUTAMYL-AMIDE HAE:ACETOHYDROXAMIC ACID ZN:ZINC ION | ||
3lir | [A] | [A] | [A] | 1.9 | CA:CALCIUM ION EEC:N-[3-(3-PHENYLISOXAZOL-5-YL)PROPANOYL]-L-ALPHA-GLUTAMYL-L-ALPHA-GLUTAMYL-AMIDE GLY:GLYCINE ZN:ZINC ION | ||
3ljg | [A] | [A] | [A] | 1.31 | CA:CALCIUM ION EEF:N-(3-BIPHENYL-4-YLPROPANOYL)-L-ALPHA-GLUTAMYL-L-ALPHA-GLUTAMYL-AMIDE HAE:ACETOHYDROXAMIC ACID P6G:HEXAETHYLENE GLYCOL ZN:ZINC ION | ||
3n2u | [A] | [A] | [A] | 1.81 | CA:CALCIUM ION D3X:N-HYDROXY-2-{[(4-METHOXYPHENYL)SULFONYL](2-{[(2R,3R,4S,5S,6R)-3,4,5-TRIHYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-2-YL]OXY}ETHYL)AMINO}ACETAMIDE ZN:ZINC ION | ||
3n2v | [A] | [A] | [A] | 1.55 | CA:CALCIUM ION JT5:N~2~-(BIPHENYL-4-YLSULFONYL)-N-HYDROXY-N~2~-(2-HYDROXYETHYL)GLYCINAMIDE ZN:ZINC ION | ||
3rts | [A] | [A] | [A] | 1.81 | CA:CALCIUM ION KLG:N-HYDROXY-N~2~-[(2-PHENYLETHYL)SULFONYL]GLYCINAMIDE ZN:ZINC ION | ||
3rtt | [A] | [A] | [A] | 1.82 | CA:CALCIUM ION KLH:N-HYDROXY-1-[(2-PHENYLETHYL)SULFONYL]-D-PROLINAMIDE ZN:ZINC ION | ||
4guy | [A] | [A] | [A] | 2 | CA:CALCIUM ION KLJ:N-HYDROXY-N~2~-{[2-(4-METHOXYPHENYL)ETHYL]SULFONYL}GLYCINAMIDE ZN:ZINC ION | ||
4ijo | [A] | [A] | [A] | 1.9 | CA:CALCIUM ION ZN:ZINC ION | ||
5cxa | [A] | [A] | [A] | 1.3 | 55L:(R)-4-(((S)-1-(((S)-1-AMINO-4-CARBOXY-1-OXOBUTAN-2-YL)AMINO)-4-CARBOXY-1-OXOBUTAN-2-YL)AMINO)-3-((3-(3___sq___-CHLORO-[1,1___sq___-BIPHENYL]-4-YL)ISOXAZOL-5-YL)METHYL)-4-OXOBUTANOATE CA:CALCIUM ION ZN:ZINC ION | ||
5czm | [A] | [A] | [A] | 1.3 | CA:CALCIUM ION R47:N-[(2S)-3-[(S)-(4-BROMOPHENYL)(HYDROXY)PHOSPHORYL]-2-{[3-(3___sq___-CHLOROBIPHENYL-4-YL)-1,2-OXAZOL-5-YL]METHYL}PROPANOYL]-L-ALPHA-GLUTAMYL-L-ALPHA-GLUTAMINE ZN:ZINC ION | ||
5d2b | [A] | [A] | [A] | 1.2 | 56O:N-[(2R)-2-{[3-(3___sq___-CHLOROBIPHENYL-4-YL)-1,2-OXAZOL-5-YL]METHYL}-4-(HYDROXYAMINO)-4-OXOBUTANOYL]-L-ALPHA-GLUTAMYL-L-ALPHA-GLUTAMINE CA:CALCIUM ION ZN:ZINC ION | ||
5d3c | [A] | [A] | [A] | 1.31 | 56O:N-[(2R)-2-{[3-(3___sq___-CHLOROBIPHENYL-4-YL)-1,2-OXAZOL-5-YL]METHYL}-4-(HYDROXYAMINO)-4-OXOBUTANOYL]-L-ALPHA-GLUTAMYL-L-ALPHA-GLUTAMINE CA:CALCIUM ION ZN:ZINC ION | ||
5i0l | [A] | [A] | [A] | 2.45 | CA:CALCIUM ION DMS:DIMETHYL SULFOXIDE EDO:1,2-ETHANEDIOL H27:(2R)-2-[{(E)-2-[({(2R,3R,4R,5S,6R)-3-(ACETYLAMINO)-4,5-BIS(ACETYLOXY)-6-[(ACETYLOXY)METHYL]TETRAHYDRO-2H-PYRAN-2-YL}CARBAMOTHIOYL)AMINO]ETHENYL}(BIPHENYL-4-YLSULFONYL)AMINO]-3-METHYLBUTANOIC ACID PEG:DI(HYDROXYETHYL)ETHER PGO:S-1,2-PROPANEDIOL ZN:ZINC ION | ||
5i2z | [A] | [A] | [A] | 2.3 | CA:CALCIUM ION DMS:DIMETHYL SULFOXIDE EDO:1,2-ETHANEDIOL PGO:S-1,2-PROPANEDIOL V24:N-[([1,1___sq___-BIPHENYL]-4-YL)SULFONYL]-N-({1-[3,4,6-TRI-O-ACETYL-2-(ACETYLAMINO)-2-DEOXY-BETA-D-GLUCOPYRANOSYL]-1H-1,2,3-TRIAZOL-4-YL}METHYL)-D-VALINE ZN:ZINC ION | ||
5i3m | [A] | [A] | [A] | 2.17 | 67F:(2S)-2-{[2-({[(2R,3R,4R,5S,6R)-3-(ACETYLAMINO)-4,5-DIHYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-2-YL]CARBAMOTHIOYL}AMINO)ETHYL](BIPHENYL-4-YLSULFONYL)AMINO}-3-METHYLBUTANOIC ACID (NON-PREFERRED NAME) CA:CALCIUM ION DIO:1,4-DIETHYLENE DIOXIDE DMS:DIMETHYL SULFOXIDE EDO:1,2-ETHANEDIOL PGO:S-1,2-PROPANEDIOL ZN:ZINC ION | ||
5i43 | [A] | [A] | [A] | 1.95 | 67M:(2R)-2-[({1-[3-({(2R,3R,4R,5S,6R)-3-(ACETYLAMINO)-4,5-BIS(ACETYLOXY)-6-[(ACETYLOXY)METHYL]TETRAHYDRO-2H-PYRAN-2-YL}OXY)PROPYL]-1H-1,2,3-TRIAZOL-4-YL}METHYL)(BIPHENYL-4-YLSULFONYL)AMINO]-3-METHYLBUTANOIC ACID(NON-PREFERRED NAME) CA:CALCIUM ION DMS:DIMETHYL SULFOXIDE EDO:1,2-ETHANEDIOL PGO:S-1,2-PROPANEDIOL ZN:ZINC ION | ||
5i4o | [A] | [A] | [A] | 2.05 | CA:CALCIUM ION V28:N-({1-[2-(ACETYLAMINO)-2-DEOXY-BETA-D-GLUCOPYRANOSYL]-1H-1,2,3-TRIAZOL-4-YL}METHYL)-N-[([1,1___sq___-BIPHENYL]-4-YL)SULFONYL]-D-VALINE ZN:ZINC ION | ||
5l79 | [A] | [A] | [A] | 2.07 | 6PJ:CY5.5-PEG2 CA:CALCIUM ION EDO:1,2-ETHANEDIOL GOL:GLYCEROL R47:N-[(2S)-3-[(S)-(4-BROMOPHENYL)(HYDROXY)PHOSPHORYL]-2-{[3-(3___sq___-CHLOROBIPHENYL-4-YL)-1,2-OXAZOL-5-YL]METHYL}PROPANOYL]-L-ALPHA-GLUTAMYL-L-ALPHA-GLUTAMINE ZN:ZINC ION | ||
5l7f | [A] | [A] | [A] | 1.8 | 6PJ:CY5.5-PEG2 BR:BROMIDE ION CA:CALCIUM ION DMS:DIMETHYL SULFOXIDE EDO:1,2-ETHANEDIOL GOL:GLYCEROL R47:N-[(2S)-3-[(S)-(4-BROMOPHENYL)(HYDROXY)PHOSPHORYL]-2-{[3-(3___sq___-CHLOROBIPHENYL-4-YL)-1,2-OXAZOL-5-YL]METHYL}PROPANOYL]-L-ALPHA-GLUTAMYL-L-ALPHA-GLUTAMINE ZN:ZINC ION | ||
5lab | [A] | [A] | [A] | 1.34 | CA:CALCIUM ION NGH:N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMICACID ZN:ZINC ION | ||
5n5j | [A] | [A] | [A] | 1.8 | 8NT:3-[5-[(3~{S})-1,2-DITHIOLAN-3-YL]PENTANOYLAMINO]PROPANE-1-SULFONIC ACID CA:CALCIUM ION HAE:ACETOHYDROXAMIC ACID ZN:ZINC ION | ||
5n5k | [A] | [A] | [A] | 1.8 | 8NW:5-[(3~{S})-1,2-DITHIOLAN-3-YL]-~{N}-(3-OXIDANYLPROPYL)PENTANAMIDE CA:CALCIUM ION HAE:ACETOHYDROXAMIC ACID ZN:ZINC ION | ||
6ekn | [A] | [A] | [A] | 1.2 | B9N:(2~{S})-2-[2-[4-(4-METHOXYPHENYL)PHENYL]SULFONYLPHENYL]PENTANEDIOIC ACID CA:CALCIUM ION EDO:1,2-ETHANEDIOL ZN:ZINC ION | ||
6ela | [A] | [A] | [A] | 1.49 | B9Z:(2~{S})-2-[2-[4-(4-METHOXYPHENYL)PHENYL]SULFANYLPHENYL]PENTANEDIOIC ACID CA:CALCIUM ION DIO:1,4-DIETHYLENE DIOXIDE EDO:1,2-ETHANEDIOL ZN:ZINC ION | ||
6enm | [A] | [A] | [A] | 1.59 | CA:CALCIUM ION LPW:2-[2-[4-(4-METHOXYPHENYL)PHENYL]SULFONYLPHENYL]-~{N}-OXIDANYL-ETHANAMIDE ZN:ZINC ION | ||
6eox | [A] | [A] | [A] | 1.3 | BKW:2-[2-[4-(4-METHOXYPHENYL)PHENYL]SULFONYLPHENYL]ETHANOICACID CA:CALCIUM ION ZN:ZINC ION | ||
6rd0 | [A] | [A] | [A] | 1.9 | CA:CALCIUM ION HAE:ACETOHYDROXAMIC ACID K0Q:~{N}-[2-(1~{H}-INDOL-3-YL)ETHYL]-2-(3-OXIDANYL-2-OXIDANYLIDENE-PYRIDIN-1-YL)ETHANAMIDE ZN:ZINC ION | ||
6rly | [A] | [A] | [A] | 2.2 | CA:CALCIUM ION HAE:ACETOHYDROXAMIC ACID K8T:2-(3-OXIDANYL-2-OXIDANYLIDENE-PYRIDIN-1-YL)-~{N}-[2-(4-PHENYLPHENYL)ETHYL]ETHANAMIDE ZN:ZINC ION |
*Chain Formula of OLIGAMI.
[ ] : Polypeptide - [AB] : Protein, [ab] : Small peptide
( ) : Nucleic acid - (AB) : DNA, (ab) : RNA
[ ] : Polypeptide - [AB] : Protein, [ab] : Small peptide
( ) : Nucleic acid - (AB) : DNA, (ab) : RNA