[A8]
- Classes: Alpha and beta proteins (a+b)
- Folds: Zincin-like
- Superfamilies: Metalloproteases ('zincins'), catalytic domain
- Families: Matrix metalloproteases, catalytic domain
- Protein Domains: Collagenase-3 (MMP-13)
- Species: Human (Homo sapiens) [TaxId: 9606]
PDB Entries
PDB ID | OPM | Mutant | Chain Formula | Resolution | HETNAM | ||
---|---|---|---|---|---|---|---|
Amino Acid sequence | SCOPe Family Level | CATH Homology Level | |||||
1eub | [A] | [A] | [A] | SOLUTION NMR |
3MP:3-METHYLPYRIDINE CA:CALCIUM ION HAV:HYDROXYAMINOVALINE MSB:1-METHYLOXY-4-SULFONE-BENZENE ZN:ZINC ION | ||
1fls | [A] | [A] | [A] | SOLUTION NMR |
CA:CALCIUM ION WAY:N-HYDROXY-2-[(4-METHOXY-BENZENESULFONYL)-PYRIDIN-3-YLMETHYL-AMINO]-3-METHYL-BENZAMIDE ZN:ZINC ION | ||
1fm1 | [A] | [A] | [A] | SOLUTION NMR |
CA:CALCIUM ION WAY:N-HYDROXY-2-[(4-METHOXY-BENZENESULFONYL)-PYRIDIN-3-YLMETHYL-AMINO]-3-METHYL-BENZAMIDE ZN:ZINC ION | ||
1xuc | [A] | [A] | [A] | 1.7 | CA:CALCIUM ION PB3:N,N___sq___-BIS(3-METHYLBENZYL)PYRIMIDINE-4,6-DICARBOXAMIDE ZN:ZINC ION | ||
1xud | [A] | [A] | [A] | 1.8 | CA:CALCIUM ION PB4:N,N___sq___-BIS(4-FLUORO-3-METHYLBENZYL)PYRIMIDINE-4,6-DICARBOXAMIDE ZN:ZINC ION | ||
1xur | [A2] | [A2] | [A2] | 1.85 | CA:CALCIUM ION PB5:N,N___sq___-BIS(PYRIDIN-3-YLMETHYL)PYRIMIDINE-4,6-DICARBOXAMIDE ZN:ZINC ION | ||
1you | [A] | [A] | [A] | 2.3 | CA:CALCIUM ION PFD:5-(2-ETHOXYETHYL)-5-[4-(4-FLUOROPHENOXY)PHENOXY]PYRIMIDINE-2,4,6(1H,3H,5H)-TRIONE SO4:SULFATE ION ZN:ZINC ION | ||
1ztq | [A] | [A] | [A] | 2 | 033:N-({4___sq___-[(1-BENZOFURAN-2-YLCARBONYL)AMINO]-1,1___sq___-BIPHENYL-4-YL}SULFONYL)-L-VALINE CA:CALCIUM ION ZN:ZINC ION | ||
2d1n | [A] | [A] | [A] | 2.37 | CA:CALCIUM ION FA4:SM-25453 ZN:ZINC ION | ||
2e2d | [AB] | [AB] | [AB] | 2 | CA:CALCIUM ION ZN:ZINC ION | ||
2ow9 | [A] | [A] | [A] | 1.74 | CA:CALCIUM ION HAE:ACETOHYDROXAMIC ACID SO4:SULFATE ION SP6:BENZYL 6-BENZYL-5,7-DIOXO-6,7-DIHYDRO-5H-[1,3]THIAZOLO[3,2-C]PYRIMIDINE-2-CARBOXYLATE ZN:ZINC ION | ||
2ozr | [A8] | [A8] | [A8] | 2.3 | CA:CALCIUM ION GG1:4-{[1-METHYL-2,4-DIOXO-6-(3-PHENYLPROP-1-YN-1-YL)-1,4-DIHYDROQUINAZOLIN-3(2H)-YL]METHYL}BENZOIC ACID HAE:ACETOHYDROXAMIC ACID ZN:ZINC ION | ||
2pjt | [A] | [A] | [A] | 2.8 | 347:TERT-BUTYL 4-({[4-(BUT-2-YN-1-YLAMINO)PHENYL]SULFONYL}METHYL)-4-[(HYDROXYAMINO)CARBONYL]PIPERIDINE-1-CARBOXYLATE CA:CALCIUM ION ZN:ZINC ION | ||
2yig | [A2] | [A2] | [A2] | 1.7 | 5EL:4-(4-{[(3S)-3-HYDROXY-1-AZABICYCLO[2.2.2]OCT-3-YL]ETHYNYL}PHENOXY)-N-(PYRIDIN-4-YLMETHYL)BENZAMIDE CA:CALCIUM ION NA:SODIUM ION ZN:ZINC ION | ||
3elm | [A4] | [A4] | [A4] | 1.9 | 24F:(2R)-({[5-(4-ETHOXYPHENYL)THIOPHEN-2-YL]SULFONYL}AMINO){1-[(1-METHYLETHOXY)CARBONYL]PIPERIDIN-4-YL}ETHANOIC ACID CA:CALCIUM ION ZN:ZINC ION | ||
3i7g | [A2] | [A2] | [A2] | 1.95 | 732:5-(4-CHLOROPHENYL)-N-[(1S)-1-CYCLOHEXYL-2-(METHYLAMINO)-2-OXOETHYL]FURAN-2-CARBOXAMIDE CA:CALCIUM ION FMT:FORMIC ACID ZN:ZINC ION | ||
3i7i | [A2] | [A2] | [A2] | 2.21 | 518:N-[4-(5-{[(1S)-1-CYCLOHEXYL-2-(METHYLAMINO)-2-OXOETHYL]CARBAMOYL}FURAN-2-YL)PHENYL]-1-BENZOFURAN-2-CARBOXAMIDE CA:CALCIUM ION ZN:ZINC ION | ||
3kec | [A] | [A] | [A] | 2.05 | 3KE:4-{[({3-[2-(4-METHOXYBENZYL)-2H-TETRAZOL-5-YL]PHENYL}CARBONYL)AMINO]METHYL}BENZOIC ACID CA:CALCIUM ION HAE:ACETOHYDROXAMIC ACID SO4:SULFATE ION ZN:ZINC ION | ||
3kej | [A] | [A] | [A] | 2.3 | 3EJ:4-[(5-{2-[(3-FLUOROBENZYL)CARBAMOYL]PYRIDIN-4-YL}-2H-TETRAZOL-2-YL)METHYL]BENZOIC ACID CA:CALCIUM ION ZN:ZINC ION | ||
3kek | [A] | [A] | [A] | 1.97 | 3EK:TRANS-4-[(3-{2-[(4-FLUOROBENZYL)CARBAMOYL]-6-METHYLPYRIDIN-4-YL}-1H-1,2,4-TRIAZOL-1-YL)METHYL]CYCLOHEXANECARBOXYLIC ACID CA:CALCIUM ION ZN:ZINC ION | ||
3kry | [A] | [A] | [A] | 1.9 | 3KR:1-(2-METHOXYETHYL)-N-OXO-4-({4-[4-(TRIFLUOROMETHOXY)PHENOXY]PHENYL}SULFONYL)PIPERIDINE-4-CARBOXAMIDE CA:CALCIUM ION ZN:ZINC ION | ||
3ljz | [A] | [A] | [A] | 2 | CA:CALCIUM ION EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID LA3:(2R)-2-[4-(1,3-BENZODIOXOL-5-YL)BENZYL]-N~4~-HYDROXY-N~1~-[(1S,2R)-2-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-YL]BUTANEDIAMIDE SO4:SULFATE ION ZN:ZINC ION | ||
3o2x | [A] | [A] | [A] | 1.9 | 3O2:N-HYDROXY-1-(2-METHOXYETHYL)-4-{[4-(3-{5-[4-(TRIFLUOROMETHOXY)PHENYL]-2H-TETRAZOL-2-YL}PROPOXY)PHENYL]SULFONYL}PIPERIDINE-4-CARBOXAMIDE CA:CALCIUM ION EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID SO4:SULFATE ION ZN:ZINC ION | ||
3tvc | [A] | [A] | [A] | 2.43 | CA:CALCIUM ION E3P:N~2~-[3-(1,1___sq___:4___sq___,1___sq______sq___-TERPHENYL-4-YL)PROPANOYL]-L-ALPHA-GLUTAMINE PEG:DI(HYDROXYETHYL)ETHER ZN:ZINC ION | ||
3wv1 | [A] | [A] | [A] | 1.98 | CA:CALCIUM ION FMT:FORMIC ACID NA:SODIUM ION WHH:4-[2-({6-FLUORO-2-[(3-METHOXYBENZYL)CARBAMOYL]-4-OXO-3,4-DIHYDROQUINAZOLIN-5-YL}OXY)ETHYL]BENZOIC ACID ZN:ZINC ION | ||
3wv2 | [A] | [A] | [A] | 2.3 | CA:CALCIUM ION NA:SODIUM ION WGG:N-(3-METHOXYBENZYL)-4-OXO-3,4-DIHYDROQUINAZOLINE-2-CARBOXAMIDE ZN:ZINC ION | ||
3wv3 | [A] | [A] | [A] | 1.6 | CA:CALCIUM ION EDO:1,2-ETHANEDIOL FMT:FORMIC ACID NA:SODIUM ION WLL:N-(3-METHOXYBENZYL)-4-OXO-3,4-DIHYDROTHIENO[2,3-D]PYRIMIDINE-2-CARBOXAMIDE ZN:ZINC ION | ||
3zxh | [A4] | [A4] | [A4] | 1.3 | CA:CALCIUM ION E41:N-HYDROXY-N^2^-(3-METHYLBUTYL)-N^2^-(NAPHTHALEN-2-YLSULFONYL)-D-VALINAMIDE GOL:GLYCEROL ZN:ZINC ION | ||
456c | [A2] | [A2] | [A2] | 2.4 | CA:CALCIUM ION CBP:2-{4-[4-(4-CHLORO-PHENOXY)-BENZENESULFONYL]-TETRAHYDRO-PYRAN-4-YL}-N-HYDROXY-ACETAMIDE ZN:ZINC ION | ||
4a7b | [A4] | [A4] | [A4] | 2.2 | 3W4:N-[(3R)-1,1-DIOXIDOTETRAHYDRO-2H-THIOPYRAN-3-YL]-4-(4-{[(3S)-3-HYDROXY-1-AZABICYCLO[2.2.2]OCT-3-YL]ETHYNYL}PHENOXY)BENZAMIDE 3W5:N-[(3S)-1,1-DIOXIDOTETRAHYDRO-2H-THIOPYRAN-3-YL]-4-(4-{[(3S)-3-HYDROXY-1-AZABICYCLO[2.2.2]OCT-3-YL]ETHYNYL}PHENOXY)BENZAMIDE CA:CALCIUM ION GOL:GLYCEROL HAE:ACETOHYDROXAMIC ACID NA:SODIUM ION ZN:ZINC ION | ||
4fu4 | [A][a] | [A][a] | [A][a] | 2.85 | CA:CALCIUM ION CL:CHLORIDE ION EDO:1,2-ETHANEDIOL ZN:ZINC ION | ||
4fvl | [A][a] | [A][a] | [A][a] | 2.44 | CA:CALCIUM ION CL:CHLORIDE ION GOL:GLYCEROL PEG:DI(HYDROXYETHYL)ETHER PGO:S-1,2-PROPANEDIOL ZN:ZINC ION | ||
4g0d | [A][a] | [A][a] | [A][a] | 2.54 | CA:CALCIUM ION CL:CHLORIDE ION GOL:GLYCEROL PEG:DI(HYDROXYETHYL)ETHER PGO:S-1,2-PROPANEDIOL ZN:ZINC ION | ||
4jp4 | [A2] | [A2] | [A2] | 1.43 | AZ4:N-[(2S)-4-(5-FLUOROPYRIMIDIN-2-YL)-1-({4-[5-(2,2,2-TRIFLUOROETHOXY)PYRIMIDIN-2-YL]PIPERAZIN-1-YL}SULFONYL)BUTAN-2-YL]-N-HYDROXYFORMAMIDE CA:CALCIUM ION NA:SODIUM ION ZN:ZINC ION | ||
4jpa | [A2] | [A2] | [A2] | 2 | AZ6:3-[({2-[4-({[(4S)-4-METHYL-2,5-DIOXOIMIDAZOLIDIN-4-YL]METHYL}SULFONYL)PIPERAZIN-1-YL]PYRIMIDIN-5-YL}OXY)METHYL]BENZONITRILE CA:CALCIUM ION NA:SODIUM ION ZN:ZINC ION | ||
4l19 | [A] | [A] | [A] | 1.66 | 1UA:2-[(4-METHYLBENZYL)SULFANYL]-3,5,6,7-TETRAHYDRO-4H-CYCLOPENTA[D]PYRIMIDIN-4-ONE CA:CALCIUM ION FMT:FORMIC ACID GOL:GLYCEROL ZN:ZINC ION | ||
5b5o | [A] | [A] | [A] | 1.2 | CA:CALCIUM ION EDO:1,2-ETHANEDIOL NA:SODIUM ION WMM:N-PHENYL-4-[(4H-1,2,4-TRIAZOL-3-YLSULFANYL)METHYL]-1,3-THIAZOL-2-AMINE ZN:ZINC ION | ||
5b5p | [A] | [A] | [A] | 1.6 | CA:CALCIUM ION WNN:4-OXO-N-{3-[2-(1H-1,2,4-TRIAZOL-3-YLSULFANYL)ETHOXY]BENZYL}-3,4-DIHYDROQUINAZOLINE-2-CARBOXAMIDE ZN:ZINC ION | ||
5bot | [A2] | [A2] | [A2] | 1.85 | 4UM:ETHYL 5-CARBAMOYL-1H-INDOLE-2-CARBOXYLATE CA:CALCIUM ION ZN:ZINC ION | ||
5boy | [A2] | [A2] | [A2] | 2.03 | 4UE:ETHYL 5-(1-METHYL-1H-IMIDAZOL-5-YL)-1H-INDOLE-2-CARBOXYLATE CA:CALCIUM ION ZN:ZINC ION | ||
5bpa | [A2] | [A2] | [A2] | 1.79 | 4UF:4-{[({5-[2-(ETHOXYCARBONYL)-1H-INDOL-5-YL]-1-METHYL-1H-PYRAZOL-3-YL}CARBONYL)AMINO]METHYL}BENZOIC ACID CA:CALCIUM ION ZN:ZINC ION | ||
5uwk | [A] | [A] | [A] | 1.6 | 8OM:(S)-3-METHYL-2-(4___sq___-(((4-OXO-4,5,6,7-TETRAHYDRO-3H-CYCLOPENTA[D]PYRIMIDIN-2-YL)THIO)METHYL)-[1,1___sq___-BIPHENYL]-4-YLSULFONAMIDO)BUTANOIC ACID CA:CALCIUM ION ZN:ZINC ION | ||
5uwl | [A] | [A] | [A] | 2.55 | 8OJ:(S)-N-(3-METHYL-1-(METHYLAMINO)-1-OXOBUTAN-2-YL)-5-(4-(((4-OXO-4,5,6,7-TETRAHYDRO-3H-CYCLOPENTA[D]PYRIMIDIN-2-YL)THIO)METHYL)PHENYL)FURAN-2-CARBOXAMIDE CA:CALCIUM ION ZN:ZINC ION | ||
5uwm | [A][a] | [A][a] | [A][a] | 1.62 | 8OA:(R)-N-(3-METHYL-1-(METHYLAMINO)-1-OXOBUTAN-2-YL)-5-(4-(((4-OXO-4,5,6,7-TETRAHYDRO-3H-CYCLOPENTA[D]PYRIMIDIN-2-YL)THIO)METHYL)PHENYL)FURAN-2-CARBOXAMIDE CA:CALCIUM ION ZN:ZINC ION | ||
6hv2 | [A][a] | [A][a] | [A][a] | 1.71 | CA:CALCIUM ION GOL:GLYCEROL ZN:ZINC ION | ||
830c | [A] | [A] | [A] | 1.6 | CA:CALCIUM ION RS1:4-[4-(4-CHLORO-PHENOXY)-BENZENESULFONYLMETHYL]-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HYDROXYAMIDE ZN:ZINC ION |
*Chain Formula of OLIGAMI.
[ ] : Polypeptide - [AB] : Protein, [ab] : Small peptide
( ) : Nucleic acid - (AB) : DNA, (ab) : RNA
[ ] : Polypeptide - [AB] : Protein, [ab] : Small peptide
( ) : Nucleic acid - (AB) : DNA, (ab) : RNA