OLIGAMI : Oligomer Architecture and Molecular Interface

PDB ID : 1e7w [A4]

Color

AR^a IR^b

Chain(OLIGAMI)
Chain(PDB)
Domain
CPK
Secondary Structure
Polar(blue)/
Nonpolar(white)

^a AR:All Residues
^b IR:Interface Residues

Style

Secondary Structure

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Slab plane

Direction	Proportion
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From back	%
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Chain

Chain name		Ribbon	Spacefill	Cαonly
OLIGAMI	PDB
A	A
B	B
C	A
D	B

Title

ONE ACTIVE SITE, TWO MODES OF REDUCTION CORRELATE THE MECHANISM OF LEISHMANIA PTERIDINE REDUCTASE WITH PTERIN METABOLISM AND ANTIFOLATE DRUG RESISTANCE IN TRPANOSOMES

Structure Summary

PDB ID	Mutant	OPM	Pub Med	Method/Resolution	HETNAM
1e7w			11373620	X-RAY DIFFRACTION/1.75	EDO:1,2-ETHANEDIOL MTX:METHOTREXATE NDP:NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

Chain Formula
Amino Acid sequence	SCOPe Family Level	CATH Homology Level
[A4]	[A4]	[A4]

Structual Classification

SCOPe

SCOPe ID	Chain	Class	Fold	Superfamily	Family	Protein Domain	Species
59373	A:	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Tyrosine-dependent oxidoreductases	Dihydropteridin reductase (pteridine reductase)	Leishmania major [TaxId: 5664]
59374	B:	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Tyrosine-dependent oxidoreductases	Dihydropteridin reductase (pteridine reductase)	Leishmania major [TaxId: 5664]

CATH

CATH ID	Node	Class	Architecture	Topology	Homology
1e7wA00	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
1e7wB00	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain