OLIGAMI : Oligomer Architecture and Molecular Interface

PDB ID : 1efk [A4]

Color

AR^a IR^b

Chain(OLIGAMI)
Chain(PDB)
Domain
CPK
Secondary Structure
Polar(blue)/
Nonpolar(white)

^a AR:All Residues
^b IR:Interface Residues

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Secondary Structure

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Chain

Chain name		Ribbon	Spacefill	Cαonly
OLIGAMI	PDB
A	A
B	B
C	C
D	D

Title

STRUCTURE OF HUMAN MALIC ENZYME IN COMPLEX WITH KETOMALONATE

Structure Summary

PDB ID	Mutant	OPM	Pub Med	Method/Resolution	HETNAM
1efk			10700286	X-RAY DIFFRACTION/2.6	MAK:ALPHA-KETOMALONIC ACID MG:MAGNESIUM ION MSE:SELENOMETHIONINE NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE

Chain Formula
Amino Acid sequence	SCOPe Family Level	CATH Homology Level
[A4]	[A4]	[A4]

Structual Classification

SCOPe

SCOPe ID	Chain	Class	Fold	Superfamily	Family	Protein Domain	Species
33947	A:21-279	Alpha and beta proteins (a/b)	Aminoacid dehydrogenase-like, N-terminal domain	Aminoacid dehydrogenase-like, N-terminal domain	Malic enzyme N-domain	Mitochondrial NAD(P)-dependent malic enzyme	Human (Homo sapiens) [TaxId: 9606]
30299	A:280-573	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Aminoacid dehydrogenase-like, C-terminal domain	Mitochondrial NAD(P)-dependent malic enzyme	Human (Homo sapiens) [TaxId: 9606]
33948	B:21-279	Alpha and beta proteins (a/b)	Aminoacid dehydrogenase-like, N-terminal domain	Aminoacid dehydrogenase-like, N-terminal domain	Malic enzyme N-domain	Mitochondrial NAD(P)-dependent malic enzyme	Human (Homo sapiens) [TaxId: 9606]
30300	B:280-573	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Aminoacid dehydrogenase-like, C-terminal domain	Mitochondrial NAD(P)-dependent malic enzyme	Human (Homo sapiens) [TaxId: 9606]
33949	C:21-279	Alpha and beta proteins (a/b)	Aminoacid dehydrogenase-like, N-terminal domain	Aminoacid dehydrogenase-like, N-terminal domain	Malic enzyme N-domain	Mitochondrial NAD(P)-dependent malic enzyme	Human (Homo sapiens) [TaxId: 9606]
30301	C:280-573	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Aminoacid dehydrogenase-like, C-terminal domain	Mitochondrial NAD(P)-dependent malic enzyme	Human (Homo sapiens) [TaxId: 9606]
33950	D:21-279	Alpha and beta proteins (a/b)	Aminoacid dehydrogenase-like, N-terminal domain	Aminoacid dehydrogenase-like, N-terminal domain	Malic enzyme N-domain	Mitochondrial NAD(P)-dependent malic enzyme	Human (Homo sapiens) [TaxId: 9606]
30302	D:280-573	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Aminoacid dehydrogenase-like, C-terminal domain	Mitochondrial NAD(P)-dependent malic enzyme	Human (Homo sapiens) [TaxId: 9606]

CATH

CATH ID	Node	Architecture	Topology	Homology
1efkA01	3.40.50.10380	:3-Layer(aba) Sandwich	:Rossmann fold	:Malic enzyme, N-terminal domain
1efkA02	3.40.50.720	:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
1efkB01	3.40.50.10380	:3-Layer(aba) Sandwich	:Rossmann fold	:Malic enzyme, N-terminal domain
1efkB02	3.40.50.720	:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
1efkC01	3.40.50.10380	:3-Layer(aba) Sandwich	:Rossmann fold	:Malic enzyme, N-terminal domain
1efkC02	3.40.50.720	:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
1efkD01	3.40.50.10380	:3-Layer(aba) Sandwich	:Rossmann fold	:Malic enzyme, N-terminal domain
1efkD02	3.40.50.720	:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain