Title
HUMAN 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE 1 MUTANT H221L COMPLEXED WITH ESTRADIOL AND NADP+
Structure Summary
PDB ID |
Mutant |
OPM |
Pub Med |
Method/Resolution |
HETNAM |
1fdu |
|
|
9525918 |
X-RAY DIFFRACTION/2.7 |
EST:ESTRADIOL NAP:NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE SO4:SULFATE ION
|
Chain Formula |
Amino Acid sequence |
SCOPe Family Level |
CATH Homology Level |
[A2] |
[A2] |
[A2] |
Interfaces
Interface ID |
Chain |
Inaterface Class |
Interface Type |
Contact Type |
1fdu_AB |
A B |
HEN
HEN |
i15_CR(H38,E3,N23)_CE(H7,E1,N7)_HH(S5)_HE(S1)_HN(L3,S10)_EN(S1)
i15_CR(H38,E3,N23)_CE(H7,E1,N7)_HH(S5)_HE(S1)_HN(L3,S10)_EN(S1)
|
c2_RP(HH59,NN9,HE1,HN35,NE5,EH1,NH35,EN5)_HH(P2,A1,S12)_HE(S2)_HN(L7,S14)_EN(L2)
c2_RP(HH59,NN9,HE1,HN35,NE5,EH1,NH35,EN5)_HH(P2,A1,S12)_HE(S2)_HN(L7,S14)_EN(L2)
|
Interface Class
Interface ID |
Interface 1 |
Interface 2 |
Domain |
Number of contact residues |
Binding site Class |
Percentages of Secondary structures(%) |
Domain |
Number of contact residues |
Binding site Class |
Percentages of Secondary structures(%) |
H |
E |
N |
H |
E |
N |
1fdu_AB |
A |
57 |
HEN |
63.2 |
100 |
33.3 |
B |
58 |
HEN |
62.1 |
3.4 |
34.5 |
Interface Type: Information for each interface
Interface ID |
chain |
Number of contact residues |
Number of elements |
Number of contacts between Secondary structure elements |
HH |
EE |
HE |
HN |
EN |
Hn |
En |
Nn |
H |
E |
N |
R |
L |
P |
A |
S |
P |
A |
S |
Ph |
Ah |
Ih |
P |
A |
S |
L |
S |
L |
S |
1fdu_AB |
A |
36 |
57 |
19 |
7 |
1 |
7 |
1 |
0 |
1 |
0 |
5 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
4 |
9 |
0 |
1 |
1fdu_AB |
B |
36 |
2 |
20 |
7 |
1 |
7 |
1 |
0 |
0 |
0 |
5 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
4 |
11 |
0 |
1 |
Contact Type: Information of contacts between interfaces
Interface ID |
Number of residue pairs between SS elements |
Number of contacts between Secondary structure elements |
H-H |
E-E |
N-N |
H-E |
H-N |
N-E |
E-H |
N-H |
E-N |
H-H |
E-E |
H-E |
H-N |
E-N |
P |
A |
S |
Ih |
P |
A |
S |
IPh |
IAh |
P |
A |
S |
Ih |
L |
S |
Ih |
L |
S |
Ih |
1fdu_AB |
59 |
0 |
10 |
1 |
30 |
5 |
1 |
36 |
5 |
2 |
1 |
12 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
2 |
0 |
7 |
12 |
0 |
2 |
0 |
2 |
Structual Classification
SCOPe
CATH