OLIGAMI : Oligomer Architecture and Molecular Interface

PDB ID : 1hyh [A4]

Color

AR^a IR^b

Chain(OLIGAMI)
Chain(PDB)
Domain
CPK
Secondary Structure
Polar(blue)/
Nonpolar(white)

^a AR:All Residues
^b IR:Interface Residues

Style

Secondary Structure

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Chain

Chain name		Ribbon	Spacefill	Cαonly
OLIGAMI	PDB
A	A
B	B
C	C
D	D

Title

CRYSTAL STRUCTURE OF L-2-HYDROXYISOCAPROATE DEHYDROGENASE FROM LACTOBACILLUS CONFUSUS AT 2.2 ANGSTROMS RESOLUTION-AN EXAMPLE OF STRONG ASYMMETRY BETWEEN SUBUNITS

Structure Summary

PDB ID	Mutant	OPM	Pub Med	Method/Resolution	HETNAM
1hyh			7643402	X-RAY DIFFRACTION/2.2	NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE SO4:SULFATE ION

Chain Formula
Amino Acid sequence	SCOPe Family Level	CATH Homology Level
[A4]	[A4]	[A4]

Structual Classification

SCOPe

SCOPe ID	Chain	Class	Fold	Superfamily	Family	Protein Domain	Species
42117	A:167-329	Alpha and beta proteins (a+b)	LDH C-terminal domain-like	LDH C-terminal domain-like	Lactate & malate dehydrogenases, C-terminal domain	L-2-hydroxyisocapronate dehydrogenase, L-HICDH	Lactobacillus confusus [TaxId: 1583]
30150	A:21-166	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	LDH N-terminal domain-like	L-2-hydroxyisocapronate dehydrogenase, L-HICDH	Lactobacillus confusus [TaxId: 1583]
42118	B:167-326	Alpha and beta proteins (a+b)	LDH C-terminal domain-like	LDH C-terminal domain-like	Lactate & malate dehydrogenases, C-terminal domain	L-2-hydroxyisocapronate dehydrogenase, L-HICDH	Lactobacillus confusus [TaxId: 1583]
30151	B:21-166	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	LDH N-terminal domain-like	L-2-hydroxyisocapronate dehydrogenase, L-HICDH	Lactobacillus confusus [TaxId: 1583]
42119	C:167-329	Alpha and beta proteins (a+b)	LDH C-terminal domain-like	LDH C-terminal domain-like	Lactate & malate dehydrogenases, C-terminal domain	L-2-hydroxyisocapronate dehydrogenase, L-HICDH	Lactobacillus confusus [TaxId: 1583]
30152	C:21-166	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	LDH N-terminal domain-like	L-2-hydroxyisocapronate dehydrogenase, L-HICDH	Lactobacillus confusus [TaxId: 1583]
42120	D:167-329	Alpha and beta proteins (a+b)	LDH C-terminal domain-like	LDH C-terminal domain-like	Lactate & malate dehydrogenases, C-terminal domain	L-2-hydroxyisocapronate dehydrogenase, L-HICDH	Lactobacillus confusus [TaxId: 1583]
30153	D:21-166	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	LDH N-terminal domain-like	L-2-hydroxyisocapronate dehydrogenase, L-HICDH	Lactobacillus confusus [TaxId: 1583]

CATH

CATH ID	Node	Architecture	Topology	Homology
1hyhA01	3.40.50.720	:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
1hyhA02	3.90.110.10	:Alpha-Beta Complex	:L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2	:Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
1hyhB01	3.40.50.720	:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
1hyhB02	3.90.110.10	:Alpha-Beta Complex	:L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2	:Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
1hyhC01	3.40.50.720	:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
1hyhC02	3.90.110.10	:Alpha-Beta Complex	:L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2	:Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
1hyhD01	3.40.50.720	:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
1hyhD02	3.90.110.10	:Alpha-Beta Complex	:L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2	:Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal