OLIGAMI : Oligomer Architecture and Molecular Interface

PDB ID : 1k0u [A4]

Color

AR^a IR^b

Chain(OLIGAMI)
Chain(PDB)
Domain
CPK
Secondary Structure
Polar(blue)/
Nonpolar(white)

^a AR:All Residues
^b IR:Interface Residues

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Secondary Structure

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Chain

Chain name		Ribbon	Spacefill	Cαonly
OLIGAMI	PDB
A	A
B	B
C	C
D	D

Title

INHIBITION OF S-ADENOSYLHOMOCYSTEINE HYDROLASE BY "ACYCLIC SUGAR" ADENOSINE ANALOGUE D-ERITADENINE

Structure Summary

PDB ID	Mutant	OPM	Pub Med	Method/Resolution	HETNAM
1k0u			11741948	X-RAY DIFFRACTION/3	DEA:D-ERITADENINE NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE

Chain Formula
Amino Acid sequence	SCOPe Family Level	CATH Homology Level
[A4]	[A4]	[A4]

Structual Classification

SCOPe

SCOPe ID	Chain	Class	Fold	Superfamily	Family	Protein Domain	Species
67970	A:190-352	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Formate/glycerate dehydrogenases, NAD-domain	S-adenosylhomocystein hydrolase	Norway rat (Rattus norvegicus) [TaxId: 10116]
67971	A:2-189 A:353-431	Alpha and beta proteins (a/b)	Flavodoxin-like	Formate/glycerate dehydrogenase catalytic domain-like	S-adenosylhomocystein hydrolase	S-adenosylhomocystein hydrolase	Norway rat (Rattus norvegicus) [TaxId: 10116]
67972	B:190-352	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Formate/glycerate dehydrogenases, NAD-domain	S-adenosylhomocystein hydrolase	Norway rat (Rattus norvegicus) [TaxId: 10116]
67973	B:2-189 B:353-431	Alpha and beta proteins (a/b)	Flavodoxin-like	Formate/glycerate dehydrogenase catalytic domain-like	S-adenosylhomocystein hydrolase	S-adenosylhomocystein hydrolase	Norway rat (Rattus norvegicus) [TaxId: 10116]
67974	C:190-352	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Formate/glycerate dehydrogenases, NAD-domain	S-adenosylhomocystein hydrolase	Norway rat (Rattus norvegicus) [TaxId: 10116]
67975	C:2-189 C:353-431	Alpha and beta proteins (a/b)	Flavodoxin-like	Formate/glycerate dehydrogenase catalytic domain-like	S-adenosylhomocystein hydrolase	S-adenosylhomocystein hydrolase	Norway rat (Rattus norvegicus) [TaxId: 10116]
67976	D:190-352	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Formate/glycerate dehydrogenases, NAD-domain	S-adenosylhomocystein hydrolase	Norway rat (Rattus norvegicus) [TaxId: 10116]
67977	D:2-189 D:353-431	Alpha and beta proteins (a/b)	Flavodoxin-like	Formate/glycerate dehydrogenase catalytic domain-like	S-adenosylhomocystein hydrolase	S-adenosylhomocystein hydrolase	Norway rat (Rattus norvegicus) [TaxId: 10116]
67978	E:190-352	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Formate/glycerate dehydrogenases, NAD-domain	S-adenosylhomocystein hydrolase	Norway rat (Rattus norvegicus) [TaxId: 10116]
67979	E:2-189 E:353-431	Alpha and beta proteins (a/b)	Flavodoxin-like	Formate/glycerate dehydrogenase catalytic domain-like	S-adenosylhomocystein hydrolase	S-adenosylhomocystein hydrolase	Norway rat (Rattus norvegicus) [TaxId: 10116]
67980	F:190-352	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Formate/glycerate dehydrogenases, NAD-domain	S-adenosylhomocystein hydrolase	Norway rat (Rattus norvegicus) [TaxId: 10116]
67981	F:2-189 F:353-431	Alpha and beta proteins (a/b)	Flavodoxin-like	Formate/glycerate dehydrogenase catalytic domain-like	S-adenosylhomocystein hydrolase	S-adenosylhomocystein hydrolase	Norway rat (Rattus norvegicus) [TaxId: 10116]
67982	G:190-352	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Formate/glycerate dehydrogenases, NAD-domain	S-adenosylhomocystein hydrolase	Norway rat (Rattus norvegicus) [TaxId: 10116]
67983	G:2-189 G:353-431	Alpha and beta proteins (a/b)	Flavodoxin-like	Formate/glycerate dehydrogenase catalytic domain-like	S-adenosylhomocystein hydrolase	S-adenosylhomocystein hydrolase	Norway rat (Rattus norvegicus) [TaxId: 10116]
67984	H:190-352	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Formate/glycerate dehydrogenases, NAD-domain	S-adenosylhomocystein hydrolase	Norway rat (Rattus norvegicus) [TaxId: 10116]
67985	H:2-189 H:353-431	Alpha and beta proteins (a/b)	Flavodoxin-like	Formate/glycerate dehydrogenase catalytic domain-like	S-adenosylhomocystein hydrolase	S-adenosylhomocystein hydrolase	Norway rat (Rattus norvegicus) [TaxId: 10116]

CATH

CATH ID	Node	Class	Architecture	Topology	Homology
1k0uA01	3.40.50.1480		:3-Layer(aba) Sandwich	:Rossmann fold	:Adenosylhomocysteinase-like
1k0uA02	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
1k0uB01	3.40.50.1480		:3-Layer(aba) Sandwich	:Rossmann fold	:Adenosylhomocysteinase-like
1k0uB02	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
1k0uC01	3.40.50.1480		:3-Layer(aba) Sandwich	:Rossmann fold	:Adenosylhomocysteinase-like
1k0uC02	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
1k0uD01	3.40.50.1480		:3-Layer(aba) Sandwich	:Rossmann fold	:Adenosylhomocysteinase-like
1k0uD02	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
1k0uE01	3.40.50.1480		:3-Layer(aba) Sandwich	:Rossmann fold	:Adenosylhomocysteinase-like
1k0uE02	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
1k0uF01	3.40.50.1480		:3-Layer(aba) Sandwich	:Rossmann fold	:Adenosylhomocysteinase-like
1k0uF02	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
1k0uG01	3.40.50.1480		:3-Layer(aba) Sandwich	:Rossmann fold	:Adenosylhomocysteinase-like
1k0uG02	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
1k0uH01	3.40.50.1480		:3-Layer(aba) Sandwich	:Rossmann fold	:Adenosylhomocysteinase-like
1k0uH02	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain