PDB ID : 1ml3 [A4]

Color

ARa IRb





 a AR:All Residues
 b IR:Interface Residues

Style





Secondary Structure


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Slab plane

Direction Proportion
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From back %
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Chain
Chain name Ribbon Spacefill Cαonly
OLIGAMI PDB
AA
BB
CC
DD
Title
EVIDENCES FOR A FLIP-FLOP CATALYTIC MECHANISM OF TRYPANOSOMA CRUZI GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE, FROM ITS CRYSTAL STRUCTURE IN COMPLEX WITH REACTED IRREVERSIBLE INHIBITOR 2-(2-PHOSPHONO-ETHYL)-ACRYLIC ACID 4-NITRO-PHENYL ESTER

Structure Summary
PDB ID Mutant OPM Pub Med Method/Resolution HETNAM
1ml3
12795610 X-RAY DIFFRACTION/2.5 CYX:(3-FORMYL-BUT-3-ENYL)-PHOSPHONIC ACID
NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Chain Formula
Amino Acid sequence SCOPe Family Level CATH Homology Level
[A4] [A4] [A4]

Structual Classification
SCOPe
SCOPe ID Chain Class Fold Superfamily Family Protein Domain Species
85001 A:1-164
A:334-359		Alpha and beta proteins (a/b)NAD(P)-binding Rossmann-fold domainsNAD(P)-binding Rossmann-fold domainsGlyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domainGlyceraldehyde-3-phosphate dehydrogenase (GAPDH)Trypanosoma cruzi [TaxId: 5693]
85002 A:165-333Alpha and beta proteins (a+b)FwdE/GAPDH domain-likeGlyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domainGAPDH-likeGlyceraldehyde-3-phosphate dehydrogenase (GAPDH)Trypanosoma cruzi [TaxId: 5693]
85003 B:1-164
B:334-359		Alpha and beta proteins (a/b)NAD(P)-binding Rossmann-fold domainsNAD(P)-binding Rossmann-fold domainsGlyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domainGlyceraldehyde-3-phosphate dehydrogenase (GAPDH)Trypanosoma cruzi [TaxId: 5693]
85004 B:165-333Alpha and beta proteins (a+b)FwdE/GAPDH domain-likeGlyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domainGAPDH-likeGlyceraldehyde-3-phosphate dehydrogenase (GAPDH)Trypanosoma cruzi [TaxId: 5693]
85005 C:1-164
C:334-359		Alpha and beta proteins (a/b)NAD(P)-binding Rossmann-fold domainsNAD(P)-binding Rossmann-fold domainsGlyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domainGlyceraldehyde-3-phosphate dehydrogenase (GAPDH)Trypanosoma cruzi [TaxId: 5693]
85006 C:165-333Alpha and beta proteins (a+b)FwdE/GAPDH domain-likeGlyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domainGAPDH-likeGlyceraldehyde-3-phosphate dehydrogenase (GAPDH)Trypanosoma cruzi [TaxId: 5693]
85007 D:1-164
D:334-359		Alpha and beta proteins (a/b)NAD(P)-binding Rossmann-fold domainsNAD(P)-binding Rossmann-fold domainsGlyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domainGlyceraldehyde-3-phosphate dehydrogenase (GAPDH)Trypanosoma cruzi [TaxId: 5693]
85008 D:165-333Alpha and beta proteins (a+b)FwdE/GAPDH domain-likeGlyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domainGAPDH-likeGlyceraldehyde-3-phosphate dehydrogenase (GAPDH)Trypanosoma cruzi [TaxId: 5693]

CATH
CATH ID Node Class Architecture Topology Homology
1ml3A013.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain
1ml3A023.30.360.10:2-Layer Sandwich:Dihydrodipicolinate Reductase; domain 2:Dihydrodipicolinate Reductase; domain 2
1ml3B013.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain
1ml3B023.30.360.10:2-Layer Sandwich:Dihydrodipicolinate Reductase; domain 2:Dihydrodipicolinate Reductase; domain 2
1ml3C013.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain
1ml3C023.30.360.10:2-Layer Sandwich:Dihydrodipicolinate Reductase; domain 2:Dihydrodipicolinate Reductase; domain 2
1ml3D013.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain
1ml3D023.30.360.10:2-Layer Sandwich:Dihydrodipicolinate Reductase; domain 2:Dihydrodipicolinate Reductase; domain 2