OLIGAMI : Oligomer Architecture and Molecular Interface

PDB ID : 1nvm [A2B2]

Color

AR^a IR^b

Chain(OLIGAMI)
Chain(PDB)
Domain
CPK
Secondary Structure
Polar(blue)/
Nonpolar(white)

^a AR:All Residues
^b IR:Interface Residues

Style

Secondary Structure

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Chain

Chain name		Ribbon	Spacefill	Cαonly
OLIGAMI	PDB
A	A
B	B
C	C
D	D

Title

CRYSTAL STRUCTURE OF A BIFUNCTIONAL ALDOLASE-DEHYDROGENASE : SEQUESTERING A REACTIVE AND VOLATILE INTERMEDIATE

Structure Summary

PDB ID	Mutant	OPM	Pub Med	Method/Resolution	HETNAM
1nvm			12764229	X-RAY DIFFRACTION/1.7	MN:MANGANESE (II) ION MPD:(4S)-2-METHYL-2,4-PENTANEDIOL NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE OXL:OXALATE ION SO4:SULFATE ION

Chain Formula
Amino Acid sequence	SCOPe Family Level	CATH Homology Level
[A2B2]	[A2B2]	[A2B2]

Structual Classification

SCOPe

SCOPe ID	Chain	Class	Fold	Superfamily	Family	Protein Domain	Species
86250	A:2-290	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Aldolase	HMGL-like	4-hydroxy-2-oxovalerate aldolase DmpG, catalytic domain	Pseudomonas sp. [TaxId: 306]
86249	A:291-341	All alpha proteins	RuvA C-terminal domain-like	post-HMGL domain-like	DmpG/LeuA communication domain-like	4-hydroxy-2-oxovalerate aldolase DmpG, communication domain	Pseudomonas sp. [TaxId: 306]
86251	B:1-131 B:287-312	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain	Acetaldehyde dehydrogenase (acylating)	Pseudomonas sp. [TaxId: 306]
86252	B:132-286	Alpha and beta proteins (a+b)	FwdE/GAPDH domain-like	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	GAPDH-like	Acetaldehyde dehydrogenase (acylating)	Pseudomonas sp. [TaxId: 306]
86253	C:291-339	All alpha proteins	RuvA C-terminal domain-like	post-HMGL domain-like	DmpG/LeuA communication domain-like	4-hydroxy-2-oxovalerate aldolase DmpG, communication domain	Pseudomonas sp. [TaxId: 306]
86254	C:3-290	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Aldolase	HMGL-like	4-hydroxy-2-oxovalerate aldolase DmpG, catalytic domain	Pseudomonas sp. [TaxId: 306]
86256	D:132-286	Alpha and beta proteins (a+b)	FwdE/GAPDH domain-like	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	GAPDH-like	Acetaldehyde dehydrogenase (acylating)	Pseudomonas sp. [TaxId: 306]
86255	D:3-131 D:287-310	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain	Acetaldehyde dehydrogenase (acylating)	Pseudomonas sp. [TaxId: 306]
86258	E:2-290	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Aldolase	HMGL-like	4-hydroxy-2-oxovalerate aldolase DmpG, catalytic domain	Pseudomonas sp. [TaxId: 306]
86257	E:291-339	All alpha proteins	RuvA C-terminal domain-like	post-HMGL domain-like	DmpG/LeuA communication domain-like	4-hydroxy-2-oxovalerate aldolase DmpG, communication domain	Pseudomonas sp. [TaxId: 306]
86260	F:132-286	Alpha and beta proteins (a+b)	FwdE/GAPDH domain-like	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	GAPDH-like	Acetaldehyde dehydrogenase (acylating)	Pseudomonas sp. [TaxId: 306]
86259	F:4-131 F:287-312	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain	Acetaldehyde dehydrogenase (acylating)	Pseudomonas sp. [TaxId: 306]
86261	G:291-341	All alpha proteins	RuvA C-terminal domain-like	post-HMGL domain-like	DmpG/LeuA communication domain-like	4-hydroxy-2-oxovalerate aldolase DmpG, communication domain	Pseudomonas sp. [TaxId: 306]
86262	G:3-290	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Aldolase	HMGL-like	4-hydroxy-2-oxovalerate aldolase DmpG, catalytic domain	Pseudomonas sp. [TaxId: 306]
86264	H:132-286	Alpha and beta proteins (a+b)	FwdE/GAPDH domain-like	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	GAPDH-like	Acetaldehyde dehydrogenase (acylating)	Pseudomonas sp. [TaxId: 306]
86263	H:4-131 H:287-310	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain	Acetaldehyde dehydrogenase (acylating)	Pseudomonas sp. [TaxId: 306]

CATH

CATH ID	Node	Class	Architecture	Topology	Homology
1nvmA01	3.20.20.70		:Alpha-Beta Barrel	:TIM Barrel	:Aldolase class I
1nvmA02	1.10.8.60		:Orthogonal Bundle	:Helicase, Ruva Protein; domain 3	:
1nvmB01	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
1nvmB02	3.30.360.10		:2-Layer Sandwich	:Dihydrodipicolinate Reductase; domain 2	:Dihydrodipicolinate Reductase; domain 2
1nvmC01	3.20.20.70		:Alpha-Beta Barrel	:TIM Barrel	:Aldolase class I
1nvmC02	1.10.8.60		:Orthogonal Bundle	:Helicase, Ruva Protein; domain 3	:
1nvmD01	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
1nvmD02	3.30.360.10		:2-Layer Sandwich	:Dihydrodipicolinate Reductase; domain 2	:Dihydrodipicolinate Reductase; domain 2
1nvmE01	3.20.20.70		:Alpha-Beta Barrel	:TIM Barrel	:Aldolase class I
1nvmE02	1.10.8.60		:Orthogonal Bundle	:Helicase, Ruva Protein; domain 3	:
1nvmF01	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
1nvmF02	3.30.360.10		:2-Layer Sandwich	:Dihydrodipicolinate Reductase; domain 2	:Dihydrodipicolinate Reductase; domain 2
1nvmG01	3.20.20.70		:Alpha-Beta Barrel	:TIM Barrel	:Aldolase class I
1nvmG02	1.10.8.60		:Orthogonal Bundle	:Helicase, Ruva Protein; domain 3	:
1nvmH01	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
1nvmH02	3.30.360.10		:2-Layer Sandwich	:Dihydrodipicolinate Reductase; domain 2	:Dihydrodipicolinate Reductase; domain 2