PDB ID : 1pj2 [A4]

Color

ARa IRb





 a AR:All Residues
 b IR:Interface Residues

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Secondary Structure


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Slab plane

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Chain
Chain name Ribbon Spacefill Cαonly
OLIGAMI PDB
AA
BB
CC
DD
Title
CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIAL NAD(P)+-DEPENDENT MALIC ENZYME IN A PENTARY COMPLEX WITH NATURAL SUBSTRATE MALATE, COFACTOR NADH, MN++, AND ALLOSTERIC ACTIVATOR FUMARATE

Structure Summary
PDB ID Mutant OPM Pub Med Method/Resolution HETNAM
1pj2
12962632 X-RAY DIFFRACTION/2.3 FUM:FUMARIC ACID
LMR:(2S)-2-HYDROXYBUTANEDIOIC ACID
MN:MANGANESE (II) ION
MSE:SELENOMETHIONINE
NAI:1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE
Chain Formula
Amino Acid sequence SCOPe Family Level CATH Homology Level
[A4] [A4] [A4]

Structual Classification
SCOPe
SCOPe ID Chain Class Fold Superfamily Family Protein Domain Species
94719 A:21-279Alpha and beta proteins (a/b)Aminoacid dehydrogenase-like, N-terminal domainAminoacid dehydrogenase-like, N-terminal domainMalic enzyme N-domainMitochondrial NAD(P)-dependent malic enzymeHuman (Homo sapiens) [TaxId: 9606]
94718 A:280-573Alpha and beta proteins (a/b)NAD(P)-binding Rossmann-fold domainsNAD(P)-binding Rossmann-fold domainsAminoacid dehydrogenase-like, C-terminal domainMitochondrial NAD(P)-dependent malic enzymeHuman (Homo sapiens) [TaxId: 9606]
94721 B:1021-1279Alpha and beta proteins (a/b)Aminoacid dehydrogenase-like, N-terminal domainAminoacid dehydrogenase-like, N-terminal domainMalic enzyme N-domainMitochondrial NAD(P)-dependent malic enzymeHuman (Homo sapiens) [TaxId: 9606]
94720 B:1280-1573Alpha and beta proteins (a/b)NAD(P)-binding Rossmann-fold domainsNAD(P)-binding Rossmann-fold domainsAminoacid dehydrogenase-like, C-terminal domainMitochondrial NAD(P)-dependent malic enzymeHuman (Homo sapiens) [TaxId: 9606]
94723 C:2021-2279Alpha and beta proteins (a/b)Aminoacid dehydrogenase-like, N-terminal domainAminoacid dehydrogenase-like, N-terminal domainMalic enzyme N-domainMitochondrial NAD(P)-dependent malic enzymeHuman (Homo sapiens) [TaxId: 9606]
94722 C:2280-2573Alpha and beta proteins (a/b)NAD(P)-binding Rossmann-fold domainsNAD(P)-binding Rossmann-fold domainsAminoacid dehydrogenase-like, C-terminal domainMitochondrial NAD(P)-dependent malic enzymeHuman (Homo sapiens) [TaxId: 9606]
94725 D:3021-3279Alpha and beta proteins (a/b)Aminoacid dehydrogenase-like, N-terminal domainAminoacid dehydrogenase-like, N-terminal domainMalic enzyme N-domainMitochondrial NAD(P)-dependent malic enzymeHuman (Homo sapiens) [TaxId: 9606]
94724 D:3280-3573Alpha and beta proteins (a/b)NAD(P)-binding Rossmann-fold domainsNAD(P)-binding Rossmann-fold domainsAminoacid dehydrogenase-like, C-terminal domainMitochondrial NAD(P)-dependent malic enzymeHuman (Homo sapiens) [TaxId: 9606]

CATH
CATH ID Node Class Architecture Topology Homology
1pj2A013.40.50.10380:3-Layer(aba) Sandwich:Rossmann fold:Malic enzyme, N-terminal domain
1pj2A023.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain
1pj2B013.40.50.10380:3-Layer(aba) Sandwich:Rossmann fold:Malic enzyme, N-terminal domain
1pj2B023.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain
1pj2C013.40.50.10380:3-Layer(aba) Sandwich:Rossmann fold:Malic enzyme, N-terminal domain
1pj2C023.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain
1pj2D013.40.50.10380:3-Layer(aba) Sandwich:Rossmann fold:Malic enzyme, N-terminal domain
1pj2D023.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain