Title
CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIAL NAD(P)+-DEPENDENT MALIC ENZYME IN A PENTARY COMPLEX WITH NATURAL SUBSTRATE PYRUVATE, COFACTOR NAD+, MN++, AND ALLOSTERIC ACTIVATOR FUMARATE.
Structure Summary
PDB ID |
Mutant |
OPM |
Pub Med |
Method/Resolution |
HETNAM |
1pj3 |
|
|
12962632 |
X-RAY DIFFRACTION/2.1 |
FUM:FUMARIC ACID MN:MANGANESE (II) ION MSE:SELENOMETHIONINE NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE PYR:PYRUVIC ACID
|
Chain Formula |
Amino Acid sequence |
SCOPe Family Level |
CATH Homology Level |
[A4] |
[A4] |
[A4] |
Structual Classification
SCOPe
SCOPe ID |
Chain |
Class |
Fold |
Superfamily |
Family |
Protein Domain |
Species |
94727 | A:21-279 | Alpha and beta proteins (a/b) | Aminoacid dehydrogenase-like, N-terminal domain | Aminoacid dehydrogenase-like, N-terminal domain | Malic enzyme N-domain | Mitochondrial NAD(P)-dependent malic enzyme | Human (Homo sapiens) [TaxId: 9606] |
94726 | A:280-573 | Alpha and beta proteins (a/b) | NAD(P)-binding Rossmann-fold domains | NAD(P)-binding Rossmann-fold domains | Aminoacid dehydrogenase-like, C-terminal domain | Mitochondrial NAD(P)-dependent malic enzyme | Human (Homo sapiens) [TaxId: 9606] |
94729 | B:1021-1279 | Alpha and beta proteins (a/b) | Aminoacid dehydrogenase-like, N-terminal domain | Aminoacid dehydrogenase-like, N-terminal domain | Malic enzyme N-domain | Mitochondrial NAD(P)-dependent malic enzyme | Human (Homo sapiens) [TaxId: 9606] |
94728 | B:1280-1573 | Alpha and beta proteins (a/b) | NAD(P)-binding Rossmann-fold domains | NAD(P)-binding Rossmann-fold domains | Aminoacid dehydrogenase-like, C-terminal domain | Mitochondrial NAD(P)-dependent malic enzyme | Human (Homo sapiens) [TaxId: 9606] |
94731 | C:2021-2279 | Alpha and beta proteins (a/b) | Aminoacid dehydrogenase-like, N-terminal domain | Aminoacid dehydrogenase-like, N-terminal domain | Malic enzyme N-domain | Mitochondrial NAD(P)-dependent malic enzyme | Human (Homo sapiens) [TaxId: 9606] |
94730 | C:2280-2573 | Alpha and beta proteins (a/b) | NAD(P)-binding Rossmann-fold domains | NAD(P)-binding Rossmann-fold domains | Aminoacid dehydrogenase-like, C-terminal domain | Mitochondrial NAD(P)-dependent malic enzyme | Human (Homo sapiens) [TaxId: 9606] |
94733 | D:3021-3279 | Alpha and beta proteins (a/b) | Aminoacid dehydrogenase-like, N-terminal domain | Aminoacid dehydrogenase-like, N-terminal domain | Malic enzyme N-domain | Mitochondrial NAD(P)-dependent malic enzyme | Human (Homo sapiens) [TaxId: 9606] |
94732 | D:3280-3573 | Alpha and beta proteins (a/b) | NAD(P)-binding Rossmann-fold domains | NAD(P)-binding Rossmann-fold domains | Aminoacid dehydrogenase-like, C-terminal domain | Mitochondrial NAD(P)-dependent malic enzyme | Human (Homo sapiens) [TaxId: 9606] |
CATH