OLIGAMI : Oligomer Architecture and Molecular Interface

PDB ID : 1pjl [A4]

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AR^a IR^b

Chain(OLIGAMI)
Chain(PDB)
Domain
CPK
Secondary Structure
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^a AR:All Residues
^b IR:Interface Residues

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Secondary Structure

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Chain

Chain name		Ribbon	Spacefill	Cαonly
OLIGAMI	PDB
A	A
B	B
C	C
D	D

Title

CRYSTAL STRUCTURE OF HUMAN M-NAD-ME IN TERNARY COMPLEX WITH NAD AND LU3+

Structure Summary

PDB ID	Mutant	OPM	Pub Med	Method/Resolution	HETNAM
1pjl			10913357	X-RAY DIFFRACTION/2.9	LU:LUTETIUM (III) ION MSE:SELENOMETHIONINE NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE

Chain Formula
Amino Acid sequence	SCOPe Family Level	CATH Homology Level
[A4]	[A4]	[A4]

Structual Classification

SCOPe

SCOPe ID	Chain	Class	Fold	Superfamily	Family	Protein Domain	Species
88124	A:23-279	Alpha and beta proteins (a/b)	Aminoacid dehydrogenase-like, N-terminal domain	Aminoacid dehydrogenase-like, N-terminal domain	Malic enzyme N-domain	Mitochondrial NAD(P)-dependent malic enzyme	Human (Homo sapiens) [TaxId: 9606]
88123	A:280-573	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Aminoacid dehydrogenase-like, C-terminal domain	Mitochondrial NAD(P)-dependent malic enzyme	Human (Homo sapiens) [TaxId: 9606]
88126	B:1023-1279	Alpha and beta proteins (a/b)	Aminoacid dehydrogenase-like, N-terminal domain	Aminoacid dehydrogenase-like, N-terminal domain	Malic enzyme N-domain	Mitochondrial NAD(P)-dependent malic enzyme	Human (Homo sapiens) [TaxId: 9606]
88125	B:1280-1573	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Aminoacid dehydrogenase-like, C-terminal domain	Mitochondrial NAD(P)-dependent malic enzyme	Human (Homo sapiens) [TaxId: 9606]
88128	C:2023-2279	Alpha and beta proteins (a/b)	Aminoacid dehydrogenase-like, N-terminal domain	Aminoacid dehydrogenase-like, N-terminal domain	Malic enzyme N-domain	Mitochondrial NAD(P)-dependent malic enzyme	Human (Homo sapiens) [TaxId: 9606]
88127	C:2280-2573	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Aminoacid dehydrogenase-like, C-terminal domain	Mitochondrial NAD(P)-dependent malic enzyme	Human (Homo sapiens) [TaxId: 9606]
88130	D:3023-3279	Alpha and beta proteins (a/b)	Aminoacid dehydrogenase-like, N-terminal domain	Aminoacid dehydrogenase-like, N-terminal domain	Malic enzyme N-domain	Mitochondrial NAD(P)-dependent malic enzyme	Human (Homo sapiens) [TaxId: 9606]
88129	D:3280-3573	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Aminoacid dehydrogenase-like, C-terminal domain	Mitochondrial NAD(P)-dependent malic enzyme	Human (Homo sapiens) [TaxId: 9606]
88132	E:4023-4279	Alpha and beta proteins (a/b)	Aminoacid dehydrogenase-like, N-terminal domain	Aminoacid dehydrogenase-like, N-terminal domain	Malic enzyme N-domain	Mitochondrial NAD(P)-dependent malic enzyme	Human (Homo sapiens) [TaxId: 9606]
88131	E:4280-4573	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Aminoacid dehydrogenase-like, C-terminal domain	Mitochondrial NAD(P)-dependent malic enzyme	Human (Homo sapiens) [TaxId: 9606]
88134	F:5023-5279	Alpha and beta proteins (a/b)	Aminoacid dehydrogenase-like, N-terminal domain	Aminoacid dehydrogenase-like, N-terminal domain	Malic enzyme N-domain	Mitochondrial NAD(P)-dependent malic enzyme	Human (Homo sapiens) [TaxId: 9606]
88133	F:5280-5573	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Aminoacid dehydrogenase-like, C-terminal domain	Mitochondrial NAD(P)-dependent malic enzyme	Human (Homo sapiens) [TaxId: 9606]
88136	G:6023-6279	Alpha and beta proteins (a/b)	Aminoacid dehydrogenase-like, N-terminal domain	Aminoacid dehydrogenase-like, N-terminal domain	Malic enzyme N-domain	Mitochondrial NAD(P)-dependent malic enzyme	Human (Homo sapiens) [TaxId: 9606]
88135	G:6280-6573	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Aminoacid dehydrogenase-like, C-terminal domain	Mitochondrial NAD(P)-dependent malic enzyme	Human (Homo sapiens) [TaxId: 9606]
88138	H:7023-7279	Alpha and beta proteins (a/b)	Aminoacid dehydrogenase-like, N-terminal domain	Aminoacid dehydrogenase-like, N-terminal domain	Malic enzyme N-domain	Mitochondrial NAD(P)-dependent malic enzyme	Human (Homo sapiens) [TaxId: 9606]
88137	H:7280-7573	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Aminoacid dehydrogenase-like, C-terminal domain	Mitochondrial NAD(P)-dependent malic enzyme	Human (Homo sapiens) [TaxId: 9606]

CATH

CATH ID	Node	Class	Architecture	Topology	Homology
1pjlA01	3.40.50.10380		:3-Layer(aba) Sandwich	:Rossmann fold	:Malic enzyme, N-terminal domain
1pjlA02	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
1pjlB01	3.40.50.10380		:3-Layer(aba) Sandwich	:Rossmann fold	:Malic enzyme, N-terminal domain
1pjlB02	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
1pjlC01	3.40.50.10380		:3-Layer(aba) Sandwich	:Rossmann fold	:Malic enzyme, N-terminal domain
1pjlC02	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
1pjlD01	3.40.50.10380		:3-Layer(aba) Sandwich	:Rossmann fold	:Malic enzyme, N-terminal domain
1pjlD02	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
1pjlE01	3.40.50.10380		:3-Layer(aba) Sandwich	:Rossmann fold	:Malic enzyme, N-terminal domain
1pjlE02	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
1pjlF01	3.40.50.10380		:3-Layer(aba) Sandwich	:Rossmann fold	:Malic enzyme, N-terminal domain
1pjlF02	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
1pjlG01	3.40.50.10380		:3-Layer(aba) Sandwich	:Rossmann fold	:Malic enzyme, N-terminal domain
1pjlG02	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
1pjlH01	3.40.50.10380		:3-Layer(aba) Sandwich	:Rossmann fold	:Malic enzyme, N-terminal domain
1pjlH02	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain