OLIGAMI : Oligomer Architecture and Molecular Interface

PDB ID : 1pl7 [A4]

Color

AR^a IR^b

Chain(OLIGAMI)
Chain(PDB)
Domain
CPK
Secondary Structure
Polar(blue)/
Nonpolar(white)

^a AR:All Residues
^b IR:Interface Residues

Style

Secondary Structure

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Slab plane

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Chain

Chain name		Ribbon	Spacefill	Cαonly
OLIGAMI	PDB
A	A
B	B
C	A
D	B

Title

HUMAN SORBITOL DEHYDROGENASE (APO)

Structure Summary

PDB ID	Mutant	OPM	Pub Med	Method/Resolution	HETNAM
1pl7			12962626	X-RAY DIFFRACTION/2.2	ZN:ZINC ION

Chain Formula
Amino Acid sequence	SCOPe Family Level	CATH Homology Level
[A4]	[A4]	[A4]

Structual Classification

SCOPe

SCOPe ID	Chain	Class	Fold	Superfamily	Family	Protein Domain	Species
94870	A:1-145 A:317-356	All beta proteins	GroES-like	GroES-like	Alcohol dehydrogenase-like, N-terminal domain	Ketose reductase (sorbitol dehydrogenase)	Human (Homo sapiens) [TaxId: 9606]
94871	A:146-316	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Alcohol dehydrogenase-like, C-terminal domain	Ketose reductase (sorbitol dehydrogenase)	Human (Homo sapiens) [TaxId: 9606]
94872	B:1-145 B:317-356	All beta proteins	GroES-like	GroES-like	Alcohol dehydrogenase-like, N-terminal domain	Ketose reductase (sorbitol dehydrogenase)	Human (Homo sapiens) [TaxId: 9606]
94873	B:146-316	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Alcohol dehydrogenase-like, C-terminal domain	Ketose reductase (sorbitol dehydrogenase)	Human (Homo sapiens) [TaxId: 9606]
94874	C:1-145 C:317-356	All beta proteins	GroES-like	GroES-like	Alcohol dehydrogenase-like, N-terminal domain	Ketose reductase (sorbitol dehydrogenase)	Human (Homo sapiens) [TaxId: 9606]
94875	C:146-316	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Alcohol dehydrogenase-like, C-terminal domain	Ketose reductase (sorbitol dehydrogenase)	Human (Homo sapiens) [TaxId: 9606]
94876	D:1-145 D:317-356	All beta proteins	GroES-like	GroES-like	Alcohol dehydrogenase-like, N-terminal domain	Ketose reductase (sorbitol dehydrogenase)	Human (Homo sapiens) [TaxId: 9606]
94877	D:146-316	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Alcohol dehydrogenase-like, C-terminal domain	Ketose reductase (sorbitol dehydrogenase)	Human (Homo sapiens) [TaxId: 9606]

CATH

CATH ID	Node	Class	Architecture	Topology	Homology
1pl7A01	3.90.180.10		:Alpha-Beta Complex	:Quinone Oxidoreductase; Chain A, domain 1	:Medium-chain alcohol dehydrogenases, catalytic domain
1pl7A02	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
1pl7B01	3.90.180.10		:Alpha-Beta Complex	:Quinone Oxidoreductase; Chain A, domain 1	:Medium-chain alcohol dehydrogenases, catalytic domain
1pl7B02	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
1pl7C01	3.90.180.10		:Alpha-Beta Complex	:Quinone Oxidoreductase; Chain A, domain 1	:Medium-chain alcohol dehydrogenases, catalytic domain
1pl7C02	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
1pl7D01	3.90.180.10		:Alpha-Beta Complex	:Quinone Oxidoreductase; Chain A, domain 1	:Medium-chain alcohol dehydrogenases, catalytic domain
1pl7D02	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain