OLIGAMI : Oligomer Architecture and Molecular Interface

PDB ID : 1t2e [A4]

AR^a IR^b

Chain(OLIGAMI)
Chain(PDB)
Domain
CPK
Secondary Structure
Polar(blue)/
Nonpolar(white)

^a AR:All Residues
^b IR:Interface Residues

Title

PLASMODIUM FALCIPARUM LACTATE DEHYDROGENASE S245A, A327P MUTANT COMPLEXED WITH NADH AND OXAMATE

Structure Summary

PDB ID	Mutant	OPM	Pub Med	Method/Resolution	HETNAM
1t2e			15117937	X-RAY DIFFRACTION/1.85	GOL:GLYCEROL NAI:1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE OXM:OXAMIC ACID

Chain Formula
Amino Acid sequence	SCOPe Family Level	CATH Homology Level
[A4]	[A4]	[A4]

Structual Classification

SCOPe

SCOPe ID	Chain	Class	Fold	Superfamily	Family	Protein Domain	Species
99087	A:164-329	Alpha and beta proteins (a+b)	LDH C-terminal domain-like	LDH C-terminal domain-like	Lactate & malate dehydrogenases, C-terminal domain	Lactate dehydrogenase	Malaria parasite (Plasmodium falciparum) [TaxId: 5833]
99086	A:18-163	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	LDH N-terminal domain-like	Lactate dehydrogenase	Malaria parasite (Plasmodium falciparum) [TaxId: 5833]
282696	A:330-331	Artifacts	Tags	Tags	Tags	C-terminal Tags	Synthetic

CATH

CATH ID	Node	Class	Architecture	Topology	Homology
1t2eA01	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
1t2eA02	3.90.110.10		:Alpha-Beta Complex	:L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2	:Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal