PDB ID : 1y5r [A2]

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ARa IRb





 a AR:All Residues
 b IR:Interface Residues

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Secondary Structure


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Chain
Chain name Ribbon Spacefill Cαonly
OLIGAMI PDB
AA
BB
Title
THE CRYSTAL STRUCTURE OF MURINE 11B-HYDROXYSTEROID DEHYDROGENASE COMPLEXED WITH CORTICOSTERONE

Structure Summary
PDB ID Mutant OPM Pub Med Method/Resolution HETNAM
1y5r
15865440 X-RAY DIFFRACTION/3 C0R:CORTICOSTERONE
NDP:NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDEPHOSPHATE
Chain Formula
Amino Acid sequence SCOPe Family Level CATH Homology Level
[A2] [A2] [A2]

Interfaces
Interface ID Chain Inaterface
Class		 Interface Type Contact Type
1y5r_AB A
B		 HN
HN		 i7_CR(H35,N24)_HH(A1,S4)_HN(L3,S9)
i12_CR(H21,N14)_HH(S3)_HN(L1,S6) 		c4_RP(HH52,NN42,HN39,NH36,EN1)_HH(P2,A3,S6)_HN(L8,S9)
c1_RP(HH16,NN23,HN20,NH18,EN1)_HH(P1,A1,S3)_HN(L4,S8)_EN(S1)

Interface Class
Interface ID Interface 1 Interface 2
Domain Number of contact residues Binding site Class Percentages of Secondary structures(%) Domain Number of contact residues Binding site Class Percentages of Secondary structures(%)
H E N H E N
1y5r_AB A 56 HN 55.4 100 44.6 B 57 HN 56.1 0 43.9

Interface Type: Information for each interface
Interface ID chain Number of contact residues Number of elements Number of contacts between Secondary structure elements
HH EE HE HN EN
Hn En Nn H E N R L P A S P A S Ph Ah Ih P A S L S L S
1y5r_AB A 31 56 25 6 0 7 0 0 0 0 3 0 0 0 0 0 0 0 0 0 3 10 0 0
1y5r_AB B 32 0 25 6 0 7 1 0 1 0 3 0 0 0 0 0 0 0 0 0 3 11 0 0

Contact Type: Information of contacts between interfaces
Interface ID Number of residue pairs between SS elements Number of contacts between Secondary structure elements
H-H E-E N-N H-E H-N N-E E-H N-H E-N H-H E-E H-E H-N E-N
P A S Ih P A S IPh IAh P A S Ih L S Ih L S Ih
1y5r_AB 47 0 34 0 39 0 0 34 0 0 3 7 0 0 0 0 0 0 0 0 0 0 9 5 0 0 0 0

Structual Classification
SCOPe
SCOPe ID Chain Class Fold Superfamily Family Protein Domain Species
122651 A:Alpha and beta proteins (a/b)NAD(P)-binding Rossmann-fold domainsNAD(P)-binding Rossmann-fold domainsTyrosine-dependent oxidoreductases11-beta-hydroxysteroid dehydrogenase 1Mouse (Mus musculus) [TaxId: 10090]
122652 B:Alpha and beta proteins (a/b)NAD(P)-binding Rossmann-fold domainsNAD(P)-binding Rossmann-fold domainsTyrosine-dependent oxidoreductases11-beta-hydroxysteroid dehydrogenase 1Mouse (Mus musculus) [TaxId: 10090]

CATH
CATH ID Node Class Architecture Topology Homology
1y5rA003.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain
1y5rB003.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain