OLIGAMI : Oligomer Architecture and Molecular Interface

PDB ID : 2b4r [A4]

Color

AR^a IR^b

Chain(OLIGAMI)
Chain(PDB)
Domain
CPK
Secondary Structure
Polar(blue)/
Nonpolar(white)

^a AR:All Residues
^b IR:Interface Residues

Style

Secondary Structure

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Slab plane

Direction	Proportion
From front	%
From back	%
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Chain

Chain name		Ribbon	Spacefill	Cαonly
OLIGAMI	PDB
A	O
B	P
C	Q
D	R

Title

CRYSTAL STRUCTURE OF GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE FROM PLASMODIUM FALCIPARUM AT 2.25 ANGSTROM RESOLUTION REVEALS INTRIGUING EXTRA ELECTRON DENSITY IN THE ACTIVE SITE

Structure Summary

PDB ID	Mutant	OPM	Pub Med	Method/Resolution	HETNAM
2b4r			16345073	X-RAY DIFFRACTION/2.25	AES:4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE GOL:GLYCEROL NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE

Chain Formula
Amino Acid sequence	SCOPe Family Level	CATH Homology Level
[A4]	[A4]	[A4]

Structual Classification

SCOPe

SCOPe ID	Chain	Class	Fold	Superfamily	Family	Protein Domain	Species
127846	O:153-318	Alpha and beta proteins (a+b)	FwdE/GAPDH domain-like	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	GAPDH-like	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)	Malaria parasite (Plasmodium falciparum) [TaxId: 5833]
285370	O:3-3	Artifacts	Tags	Tags	Tags	N-terminal Tags	Synthetic
285371	O:336-336	Artifacts	Tags	Tags	Tags	C-terminal Tags	Synthetic
127845	O:4-152 O:319-335	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)	Malaria parasite (Plasmodium falciparum) [TaxId: 5833]
127848	P:153-318	Alpha and beta proteins (a+b)	FwdE/GAPDH domain-like	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	GAPDH-like	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)	Malaria parasite (Plasmodium falciparum) [TaxId: 5833]
285372	P:3-3	Artifacts	Tags	Tags	Tags	N-terminal Tags	Synthetic
285373	P:336-336	Artifacts	Tags	Tags	Tags	C-terminal Tags	Synthetic
127847	P:4-152 P:319-335	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)	Malaria parasite (Plasmodium falciparum) [TaxId: 5833]
127850	Q:153-318	Alpha and beta proteins (a+b)	FwdE/GAPDH domain-like	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	GAPDH-like	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)	Malaria parasite (Plasmodium falciparum) [TaxId: 5833]
285374	Q:3-3	Artifacts	Tags	Tags	Tags	N-terminal Tags	Synthetic
285375	Q:336-336	Artifacts	Tags	Tags	Tags	C-terminal Tags	Synthetic
127849	Q:4-152 Q:319-335	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)	Malaria parasite (Plasmodium falciparum) [TaxId: 5833]
127852	R:153-318	Alpha and beta proteins (a+b)	FwdE/GAPDH domain-like	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	GAPDH-like	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)	Malaria parasite (Plasmodium falciparum) [TaxId: 5833]
285376	R:3-3	Artifacts	Tags	Tags	Tags	N-terminal Tags	Synthetic
285377	R:336-336	Artifacts	Tags	Tags	Tags	C-terminal Tags	Synthetic
127851	R:4-152 R:319-335	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)	Malaria parasite (Plasmodium falciparum) [TaxId: 5833]

CATH

CATH ID	Node	Class	Architecture	Topology	Homology
2b4rO01	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
2b4rO02	3.30.360.10		:2-Layer Sandwich	:Dihydrodipicolinate Reductase; domain 2	:Dihydrodipicolinate Reductase; domain 2
2b4rP01	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
2b4rP02	3.30.360.10		:2-Layer Sandwich	:Dihydrodipicolinate Reductase; domain 2	:Dihydrodipicolinate Reductase; domain 2
2b4rQ01	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
2b4rQ02	3.30.360.10		:2-Layer Sandwich	:Dihydrodipicolinate Reductase; domain 2	:Dihydrodipicolinate Reductase; domain 2
2b4rR01	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
2b4rR02	3.30.360.10		:2-Layer Sandwich	:Dihydrodipicolinate Reductase; domain 2	:Dihydrodipicolinate Reductase; domain 2