OLIGAMI : Oligomer Architecture and Molecular Interface

PDB ID : 2hk8 [A]

Color

AR^a IR^b

Chain(OLIGAMI)
Chain(PDB)
Domain
CPK
Secondary Structure
Polar(blue)/
Nonpolar(white)

^a AR:All Residues
^b IR:Interface Residues

Style

Secondary Structure

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Chain

Chain name		Ribbon	Spacefill	Cαonly
OLIGAMI	PDB
A	A

Title

CRYSTAL STRUCTURE OF SHIKIMATE DEHYDROGENASE FROM AQUIFEX AEOLICUS AT 2.35 ANGSTROM RESOLUTION

Structure Summary

PDB ID	Mutant	OPM	Pub Med	Method/Resolution	HETNAM
2hk8			17649975	X-RAY DIFFRACTION/2.35

Chain Formula
Amino Acid sequence	SCOPe Family Level	CATH Homology Level
[A]	[A]	[A]

Structual Classification

SCOPe

SCOPe ID	Chain	Class	Fold	Superfamily	Family	Protein Domain	Species
204594	A:1-105	Alpha and beta proteins (a/b)	Aminoacid dehydrogenase-like, N-terminal domain	Aminoacid dehydrogenase-like, N-terminal domain	Shikimate dehydrogenase-like	Shikimate 5-dehydrogenase AroE	Aquifex aeolicus [TaxId: 63363]
204595	A:106-266	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Aminoacid dehydrogenase-like, C-terminal domain	Shikimate 5-dehydrogenase AroE	Aquifex aeolicus [TaxId: 63363]
204596	B:1-105	Alpha and beta proteins (a/b)	Aminoacid dehydrogenase-like, N-terminal domain	Aminoacid dehydrogenase-like, N-terminal domain	Shikimate dehydrogenase-like	Shikimate 5-dehydrogenase AroE	Aquifex aeolicus [TaxId: 63363]
204597	B:106-266	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Aminoacid dehydrogenase-like, C-terminal domain	Shikimate 5-dehydrogenase AroE	Aquifex aeolicus [TaxId: 63363]
204598	C:1-105	Alpha and beta proteins (a/b)	Aminoacid dehydrogenase-like, N-terminal domain	Aminoacid dehydrogenase-like, N-terminal domain	Shikimate dehydrogenase-like	Shikimate 5-dehydrogenase AroE	Aquifex aeolicus [TaxId: 63363]
204599	C:106-265	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Aminoacid dehydrogenase-like, C-terminal domain	Shikimate 5-dehydrogenase AroE	Aquifex aeolicus [TaxId: 63363]
204600	D:1-105	Alpha and beta proteins (a/b)	Aminoacid dehydrogenase-like, N-terminal domain	Aminoacid dehydrogenase-like, N-terminal domain	Shikimate dehydrogenase-like	Shikimate 5-dehydrogenase AroE	Aquifex aeolicus [TaxId: 63363]
204601	D:106-266	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Aminoacid dehydrogenase-like, C-terminal domain	Shikimate 5-dehydrogenase AroE	Aquifex aeolicus [TaxId: 63363]
204602	E:1-105	Alpha and beta proteins (a/b)	Aminoacid dehydrogenase-like, N-terminal domain	Aminoacid dehydrogenase-like, N-terminal domain	Shikimate dehydrogenase-like	Shikimate 5-dehydrogenase AroE	Aquifex aeolicus [TaxId: 63363]
204603	E:106-266	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Aminoacid dehydrogenase-like, C-terminal domain	Shikimate 5-dehydrogenase AroE	Aquifex aeolicus [TaxId: 63363]
204604	F:1-105	Alpha and beta proteins (a/b)	Aminoacid dehydrogenase-like, N-terminal domain	Aminoacid dehydrogenase-like, N-terminal domain	Shikimate dehydrogenase-like	Shikimate 5-dehydrogenase AroE	Aquifex aeolicus [TaxId: 63363]
204605	F:106-264	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Aminoacid dehydrogenase-like, C-terminal domain	Shikimate 5-dehydrogenase AroE	Aquifex aeolicus [TaxId: 63363]
204606	G:1-105	Alpha and beta proteins (a/b)	Aminoacid dehydrogenase-like, N-terminal domain	Aminoacid dehydrogenase-like, N-terminal domain	Shikimate dehydrogenase-like	Shikimate 5-dehydrogenase AroE	Aquifex aeolicus [TaxId: 63363]
204607	G:106-266	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Aminoacid dehydrogenase-like, C-terminal domain	Shikimate 5-dehydrogenase AroE	Aquifex aeolicus [TaxId: 63363]
204608	H:1-105	Alpha and beta proteins (a/b)	Aminoacid dehydrogenase-like, N-terminal domain	Aminoacid dehydrogenase-like, N-terminal domain	Shikimate dehydrogenase-like	Shikimate 5-dehydrogenase AroE	Aquifex aeolicus [TaxId: 63363]
204609	H:106-266	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Aminoacid dehydrogenase-like, C-terminal domain	Shikimate 5-dehydrogenase AroE	Aquifex aeolicus [TaxId: 63363]

CATH

CATH ID	Node	Class	Architecture	Topology	Homology
2hk8A01	3.40.50.10860		:3-Layer(aba) Sandwich	:Rossmann fold	:Leucine Dehydrogenase, chain A, domain 1
2hk8A02	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
2hk8B01	3.40.50.10860		:3-Layer(aba) Sandwich	:Rossmann fold	:Leucine Dehydrogenase, chain A, domain 1
2hk8B02	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
2hk8C01	3.40.50.10860		:3-Layer(aba) Sandwich	:Rossmann fold	:Leucine Dehydrogenase, chain A, domain 1
2hk8C02	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
2hk8D01	3.40.50.10860		:3-Layer(aba) Sandwich	:Rossmann fold	:Leucine Dehydrogenase, chain A, domain 1
2hk8D02	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
2hk8E01	3.40.50.10860		:3-Layer(aba) Sandwich	:Rossmann fold	:Leucine Dehydrogenase, chain A, domain 1
2hk8E02	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
2hk8F01	3.40.50.10860		:3-Layer(aba) Sandwich	:Rossmann fold	:Leucine Dehydrogenase, chain A, domain 1
2hk8F02	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
2hk8G01	3.40.50.10860		:3-Layer(aba) Sandwich	:Rossmann fold	:Leucine Dehydrogenase, chain A, domain 1
2hk8G02	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
2hk8H01	3.40.50.10860		:3-Layer(aba) Sandwich	:Rossmann fold	:Leucine Dehydrogenase, chain A, domain 1
2hk8H02	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain