PDB ID : 2xpc [A]

Color

ARa IRb





 a AR:All Residues
 b IR:Interface Residues

Style





Secondary Structure


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Slab plane

Direction Proportion
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Chain
Chain name Ribbon Spacefill Cαonly
OLIGAMI PDB
AA
Title
SECOND-GENERATION SULFONAMIDE INHIBITORS OF MURD: ACTIVITY OPTIMISATION WITH CONFORMATIONALLY RIGID ANALOGUES OF D-GLUTAMIC ACID

Structure Summary
PDB ID Mutant OPM Pub Med Method/Resolution HETNAM
2xpc
21524830 X-RAY DIFFRACTION/1.49 051:(1R,3R,4S)-4-[({6-[(4-CYANO-2-FLUOROBENZYL)OXY]NAPHTHALEN-2-YL}SULFONYL)AMINO]CYCLOHEXANE-1,3-DICARBOXYLIC ACID
CL:CHLORIDE ION
DMS:DIMETHYL SULFOXIDE
KCX:LYSINE NZ-CARBOXYLIC ACID
SO4:SULFATE ION
Chain Formula
Amino Acid sequence SCOPe Family Level CATH Homology Level
[A] [A] [A]

Structual Classification
SCOPe
SCOPe ID Chain Class Fold Superfamily Family Protein Domain Species
244565 A:1-93Alpha and beta proteins (a/b)MurCD N-terminal domainMurCD N-terminal domainautomated matchesautomated matchesEscherichia coli [TaxId: 562]
244567 A:298-437Alpha and beta proteins (a/b)MurD-like peptide ligases, peptide-binding domainMurD-like peptide ligases, peptide-binding domainautomated matchesautomated matchesEscherichia coli [TaxId: 562]
290239 A:438-439ArtifactsTagsTagsTagsC-terminal TagsSynthetic
244566 A:94-297Alpha and beta proteins (a/b)Ribokinase-likeMurD-like peptide ligases, catalytic domainMurCDEFautomated matchesEscherichia coli [TaxId: 562]

CATH
CATH ID Node Class Architecture Topology Homology
2xpcA013.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain
2xpcA023.40.1190.10:3-Layer(aba) Sandwich:UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase:Mur-like, catalytic domain
2xpcA033.90.190.20:Alpha-Beta Complex:Protein-Tyrosine Phosphatase; Chain A:Mur ligase, C-terminal domain