OLIGAMI : Oligomer Architecture and Molecular Interface

PDB ID : 3d5q [A4]

AR^a IR^b

Chain(OLIGAMI)
Chain(PDB)
Domain
CPK
Secondary Structure
Polar(blue)/
Nonpolar(white)

^a AR:All Residues
^b IR:Interface Residues

Title

CRYSTAL STRUCTURE OF 11B-HSD1 IN COMPLEX WITH TRIAZOLE INHIBITOR

Structure Summary

PDB ID	Mutant	OPM	Pub Med	Method/Resolution	HETNAM
3d5q			18789704	X-RAY DIFFRACTION/2.55	NAP:NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE T30:3-[1-(4-FLUOROPHENYL)CYCLOPROPYL]-4-(1-METHYLETHYL)-5-[4-(TRIFLUOROMETHOXY)PHENYL]-4H-1,2,4-TRIAZOLE

Chain Formula
Amino Acid sequence	SCOPe Family Level	CATH Homology Level
[A4]	[A4]	[A4]

Structual Classification

SCOPe

SCOPe ID	Chain	Class	Fold	Superfamily	Family	Protein Domain	Species
291459	A:21-23	Artifacts	Tags	Tags	Tags	N-terminal Tags	Synthetic
157399	A:24-289	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Tyrosine-dependent oxidoreductases	11-beta-hydroxysteroid dehydrogenase 1	Human (Homo sapiens) [TaxId: 9606]
291460	B:21-23	Artifacts	Tags	Tags	Tags	N-terminal Tags	Synthetic
157400	B:24-284	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Tyrosine-dependent oxidoreductases	11-beta-hydroxysteroid dehydrogenase 1	Human (Homo sapiens) [TaxId: 9606]
291461	C:23-23	Artifacts	Tags	Tags	Tags	N-terminal Tags	Synthetic
157401	C:24-281	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Tyrosine-dependent oxidoreductases	11-beta-hydroxysteroid dehydrogenase 1	Human (Homo sapiens) [TaxId: 9606]
291462	D:21-23	Artifacts	Tags	Tags	Tags	N-terminal Tags	Synthetic
157402	D:24-281	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Tyrosine-dependent oxidoreductases	11-beta-hydroxysteroid dehydrogenase 1	Human (Homo sapiens) [TaxId: 9606]

CATH

CATH ID	Node	Architecture	Topology	Homology
3d5qA00	3.40.50.720	:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
3d5qB00	3.40.50.720	:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
3d5qC00	3.40.50.720	:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
3d5qD00	3.40.50.720	:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain