PDB ID : 3frj [A4]

Color

ARa IRb





 a AR:All Residues
 b IR:Interface Residues

Style





Secondary Structure


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Slab plane

Direction Proportion
From front %
From back %
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Chain
Chain name Ribbon Spacefill Cαonly
OLIGAMI PDB
AA
BB
CA
DB
Title
CRYSTAL STRUCTURE OF 11B-HYDROXYSTEROID DEHYDROGENASE-1 (11B-HSD1) IN COMPLEX WITH PIPERIDYL BENZAMIDE INHIBITOR

Structure Summary
PDB ID Mutant OPM Pub Med Method/Resolution HETNAM
3frj
19217779 X-RAY DIFFRACTION/2.3 A49:N-{1-[(1-CARBAMOYLCYCLOPROPYL)METHYL]PIPERIDIN-4-YL}-N-CYCLOPROPYL-4-[(1S)-2,2,2-TRIFLUORO-1-HYDROXY-1-METHYLETHYL]BENZAMIDE
NAP:NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Chain Formula
Amino Acid sequence SCOPe Family Level CATH Homology Level
[A4] [A4] [A4]

Structual Classification
SCOPe
SCOPe ID Chain Class Fold Superfamily Family Protein Domain Species
292291 A:21-23ArtifactsTagsTagsTagsN-terminal TagsSynthetic
176002 A:24-284Alpha and beta proteins (a/b)NAD(P)-binding Rossmann-fold domainsNAD(P)-binding Rossmann-fold domainsTyrosine-dependent oxidoreductases11-beta-hydroxysteroid dehydrogenase 1Human (Homo sapiens) [TaxId: 9606]
292292 B:20-23ArtifactsTagsTagsTagsN-terminal TagsSynthetic
176003 B:24-284Alpha and beta proteins (a/b)NAD(P)-binding Rossmann-fold domainsNAD(P)-binding Rossmann-fold domainsTyrosine-dependent oxidoreductases11-beta-hydroxysteroid dehydrogenase 1Human (Homo sapiens) [TaxId: 9606]

CATH
CATH ID Node Class Architecture Topology Homology
3frjA003.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain
3frjB003.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain