PDB ID : 3gzn [ABC]

Color

ARa IRb





 a AR:All Residues
 b IR:Interface Residues

Style





Secondary Structure


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Slab plane

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Chain
Chain name Ribbon Spacefill Cαonly
OLIGAMI PDB
AA
BB
CI
Title
STRUCTURE OF NEDD8-ACTIVATING ENZYME IN COMPLEX WITH NEDD8 AND MLN4924

Structure Summary
PDB ID Mutant OPM Pub Med Method/Resolution HETNAM
3gzn
20129059 X-RAY DIFFRACTION/3 B39:[(1S,2S,4R)-4-{4-[(1S)-2,3-DIHYDRO-1H-INDEN-1-YLAMINO]-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL}-2-HYDROXYCYCLOPENTYL]METHYL SULFAMATE
ZN:ZINC ION
Chain Formula
Amino Acid sequence SCOPe Family Level CATH Homology Level
[ABC] [A2B] [A2B]

Structual Classification
SCOPe
SCOPe ID Chain Class Fold Superfamily Family Protein Domain Species
246396 A:Alpha and beta proteins (a/b)Activating enzymes of the ubiquitin-like proteinsActivating enzymes of the ubiquitin-like proteinsUbiquitin activating enzymes (UBA)Amyloid beta precursor protein-binding protein 1, APPBP1Human (Homo sapiens) [TaxId: 9606]
246397 B:Alpha and beta proteins (a/b)Activating enzymes of the ubiquitin-like proteinsActivating enzymes of the ubiquitin-like proteinsUbiquitin activating enzymes (UBA)UBA3Human (Homo sapiens) [TaxId: 9606]
246398 C:Alpha and beta proteins (a/b)Activating enzymes of the ubiquitin-like proteinsActivating enzymes of the ubiquitin-like proteinsUbiquitin activating enzymes (UBA)Amyloid beta precursor protein-binding protein 1, APPBP1Human (Homo sapiens) [TaxId: 9606]
246399 D:Alpha and beta proteins (a/b)Activating enzymes of the ubiquitin-like proteinsActivating enzymes of the ubiquitin-like proteinsUbiquitin activating enzymes (UBA)UBA3Human (Homo sapiens) [TaxId: 9606]
292627 I:-2-0ArtifactsTagsTagsTagsN-terminal TagsSynthetic
246400 I:1-76Alpha and beta proteins (a+b)beta-Grasp (ubiquitin-like)Ubiquitin-likeUbiquitin-relatedNedd8Human (Homo sapiens) [TaxId: 9606]
292628 J:-2-0ArtifactsTagsTagsTagsN-terminal TagsSynthetic
246401 J:1-76Alpha and beta proteins (a+b)beta-Grasp (ubiquitin-like)Ubiquitin-likeUbiquitin-relatedNedd8Human (Homo sapiens) [TaxId: 9606]

CATH
CATH ID Node Class Architecture Topology Homology
3gznA013.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain
3gznB013.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain
3gznB021.10.10.520:Orthogonal Bundle:Arc Repressor Mutant, subunit A:Ubiquitin activating enzymes (Uba3). Chain: B, domain 2
3gznB033.10.20.260:Roll:Ubiquitin-like (UB roll):NEDD8-activating enzyme E1, catalytic subunit
3gznC013.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain
3gznD013.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain
3gznD021.10.10.520:Orthogonal Bundle:Arc Repressor Mutant, subunit A:Ubiquitin activating enzymes (Uba3). Chain: B, domain 2
3gznD033.10.20.260:Roll:Ubiquitin-like (UB roll):NEDD8-activating enzyme E1, catalytic subunit
3gznI003.10.20.90:Roll:Ubiquitin-like (UB roll):Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
3gznJ003.10.20.90:Roll:Ubiquitin-like (UB roll):Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1