PDB ID : 4i8x [A4]

Color

ARa IRb





 a AR:All Residues
 b IR:Interface Residues

Style





Secondary Structure


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Slab plane

Direction Proportion
From front %
From back %
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Chain
Chain name Ribbon Spacefill Cαonly
OLIGAMI PDB
AA
BC
CB
DD
Title
CRYSTAL STRUCTURE OF RABBIT LDHA IN COMPLEX WITH AP27460

Structure Summary
PDB ID Mutant OPM Pub Med Method/Resolution HETNAM
4i8x
23302067 X-RAY DIFFRACTION/2.23 6P3:6-PHENYLPYRIDINE-3-CARBOXYLIC ACID
Chain Formula
Amino Acid sequence SCOPe Family Level CATH Homology Level
[A4] [A4] [A4]

Structual Classification
SCOPe
SCOPe ID Chain Class Fold Superfamily Family Protein Domain Species
223016 A:1-159Alpha and beta proteins (a/b)NAD(P)-binding Rossmann-fold domainsNAD(P)-binding Rossmann-fold domainsLDH N-terminal domain-likeautomated matchesRabbit (Oryctolagus cuniculus) [TaxId: 9986]
223017 A:160-331Alpha and beta proteins (a+b)LDH C-terminal domain-likeLDH C-terminal domain-likeLactate & malate dehydrogenases, C-terminal domainautomated matchesRabbit (Oryctolagus cuniculus) [TaxId: 9986]
223018 B:1-159Alpha and beta proteins (a/b)NAD(P)-binding Rossmann-fold domainsNAD(P)-binding Rossmann-fold domainsLDH N-terminal domain-likeautomated matchesRabbit (Oryctolagus cuniculus) [TaxId: 9986]
223019 B:160-331Alpha and beta proteins (a+b)LDH C-terminal domain-likeLDH C-terminal domain-likeLactate & malate dehydrogenases, C-terminal domainautomated matchesRabbit (Oryctolagus cuniculus) [TaxId: 9986]
223020 C:1-159Alpha and beta proteins (a/b)NAD(P)-binding Rossmann-fold domainsNAD(P)-binding Rossmann-fold domainsLDH N-terminal domain-likeautomated matchesRabbit (Oryctolagus cuniculus) [TaxId: 9986]
223021 C:160-331Alpha and beta proteins (a+b)LDH C-terminal domain-likeLDH C-terminal domain-likeLactate & malate dehydrogenases, C-terminal domainautomated matchesRabbit (Oryctolagus cuniculus) [TaxId: 9986]
223022 D:1-159Alpha and beta proteins (a/b)NAD(P)-binding Rossmann-fold domainsNAD(P)-binding Rossmann-fold domainsLDH N-terminal domain-likeautomated matchesRabbit (Oryctolagus cuniculus) [TaxId: 9986]
223023 D:160-331Alpha and beta proteins (a+b)LDH C-terminal domain-likeLDH C-terminal domain-likeLactate & malate dehydrogenases, C-terminal domainautomated matchesRabbit (Oryctolagus cuniculus) [TaxId: 9986]
223024 E:1-159Alpha and beta proteins (a/b)NAD(P)-binding Rossmann-fold domainsNAD(P)-binding Rossmann-fold domainsLDH N-terminal domain-likeautomated matchesRabbit (Oryctolagus cuniculus) [TaxId: 9986]
223025 E:160-331Alpha and beta proteins (a+b)LDH C-terminal domain-likeLDH C-terminal domain-likeLactate & malate dehydrogenases, C-terminal domainautomated matchesRabbit (Oryctolagus cuniculus) [TaxId: 9986]
223026 F:1-159Alpha and beta proteins (a/b)NAD(P)-binding Rossmann-fold domainsNAD(P)-binding Rossmann-fold domainsLDH N-terminal domain-likeautomated matchesRabbit (Oryctolagus cuniculus) [TaxId: 9986]
223027 F:160-331Alpha and beta proteins (a+b)LDH C-terminal domain-likeLDH C-terminal domain-likeLactate & malate dehydrogenases, C-terminal domainautomated matchesRabbit (Oryctolagus cuniculus) [TaxId: 9986]
223028 G:1-159Alpha and beta proteins (a/b)NAD(P)-binding Rossmann-fold domainsNAD(P)-binding Rossmann-fold domainsLDH N-terminal domain-likeautomated matchesRabbit (Oryctolagus cuniculus) [TaxId: 9986]
223029 G:160-331Alpha and beta proteins (a+b)LDH C-terminal domain-likeLDH C-terminal domain-likeLactate & malate dehydrogenases, C-terminal domainautomated matchesRabbit (Oryctolagus cuniculus) [TaxId: 9986]
223030 H:1-159Alpha and beta proteins (a/b)NAD(P)-binding Rossmann-fold domainsNAD(P)-binding Rossmann-fold domainsLDH N-terminal domain-likeautomated matchesRabbit (Oryctolagus cuniculus) [TaxId: 9986]
223031 H:160-331Alpha and beta proteins (a+b)LDH C-terminal domain-likeLDH C-terminal domain-likeLactate & malate dehydrogenases, C-terminal domainautomated matchesRabbit (Oryctolagus cuniculus) [TaxId: 9986]

CATH
CATH ID Node Class Architecture Topology Homology
4i8xA013.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain
4i8xA023.90.110.10:Alpha-Beta Complex:L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2:Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
4i8xB013.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain
4i8xB023.90.110.10:Alpha-Beta Complex:L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2:Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
4i8xC013.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain
4i8xC023.90.110.10:Alpha-Beta Complex:L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2:Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
4i8xD013.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain
4i8xD023.90.110.10:Alpha-Beta Complex:L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2:Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
4i8xE013.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain
4i8xE023.90.110.10:Alpha-Beta Complex:L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2:Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
4i8xF013.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain
4i8xF023.90.110.10:Alpha-Beta Complex:L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2:Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
4i8xG013.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain
4i8xG023.90.110.10:Alpha-Beta Complex:L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2:Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
4i8xH013.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain
4i8xH023.90.110.10:Alpha-Beta Complex:L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2:Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal