PDB ID : 4i9u [A4]

Color

ARa IRb





 a AR:All Residues
 b IR:Interface Residues

Style





Secondary Structure


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Slab plane

Direction Proportion
From front %
From back %
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Chain
Chain name Ribbon Spacefill Cαonly
OLIGAMI PDB
AA
BC
CB
DD
Title
CRYSTAL STRUCTURE OF RABBIT LDHA IN COMPLEX WITH A FRAGMENT INHIBITOR AP26256

Structure Summary
PDB ID Mutant OPM Pub Med Method/Resolution HETNAM
4i9u
23302067 X-RAY DIFFRACTION/2.5 1E7:6-({2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-2-OXOETHYL}SULFANYL)PYRIDINE-3-CARBOXYLIC ACID
Chain Formula
Amino Acid sequence SCOPe Family Level CATH Homology Level
[A4] [A4] [A4]

Structual Classification
SCOPe
SCOPe ID Chain Class Fold Superfamily Family Protein Domain Species
223066 A:1-159Alpha and beta proteins (a/b)NAD(P)-binding Rossmann-fold domainsNAD(P)-binding Rossmann-fold domainsLDH N-terminal domain-likeautomated matchesRabbit (Oryctolagus cuniculus) [TaxId: 9986]
223067 A:160-331Alpha and beta proteins (a+b)LDH C-terminal domain-likeLDH C-terminal domain-likeLactate & malate dehydrogenases, C-terminal domainautomated matchesRabbit (Oryctolagus cuniculus) [TaxId: 9986]
223068 B:1-159Alpha and beta proteins (a/b)NAD(P)-binding Rossmann-fold domainsNAD(P)-binding Rossmann-fold domainsLDH N-terminal domain-likeautomated matchesRabbit (Oryctolagus cuniculus) [TaxId: 9986]
223069 B:160-331Alpha and beta proteins (a+b)LDH C-terminal domain-likeLDH C-terminal domain-likeLactate & malate dehydrogenases, C-terminal domainautomated matchesRabbit (Oryctolagus cuniculus) [TaxId: 9986]
223070 C:1-159Alpha and beta proteins (a/b)NAD(P)-binding Rossmann-fold domainsNAD(P)-binding Rossmann-fold domainsLDH N-terminal domain-likeautomated matchesRabbit (Oryctolagus cuniculus) [TaxId: 9986]
223071 C:160-331Alpha and beta proteins (a+b)LDH C-terminal domain-likeLDH C-terminal domain-likeLactate & malate dehydrogenases, C-terminal domainautomated matchesRabbit (Oryctolagus cuniculus) [TaxId: 9986]
223072 D:1-159Alpha and beta proteins (a/b)NAD(P)-binding Rossmann-fold domainsNAD(P)-binding Rossmann-fold domainsLDH N-terminal domain-likeautomated matchesRabbit (Oryctolagus cuniculus) [TaxId: 9986]
223073 D:160-331Alpha and beta proteins (a+b)LDH C-terminal domain-likeLDH C-terminal domain-likeLactate & malate dehydrogenases, C-terminal domainautomated matchesRabbit (Oryctolagus cuniculus) [TaxId: 9986]
223074 E:1-159Alpha and beta proteins (a/b)NAD(P)-binding Rossmann-fold domainsNAD(P)-binding Rossmann-fold domainsLDH N-terminal domain-likeautomated matchesRabbit (Oryctolagus cuniculus) [TaxId: 9986]
223075 E:160-331Alpha and beta proteins (a+b)LDH C-terminal domain-likeLDH C-terminal domain-likeLactate & malate dehydrogenases, C-terminal domainautomated matchesRabbit (Oryctolagus cuniculus) [TaxId: 9986]
223076 F:1-159Alpha and beta proteins (a/b)NAD(P)-binding Rossmann-fold domainsNAD(P)-binding Rossmann-fold domainsLDH N-terminal domain-likeautomated matchesRabbit (Oryctolagus cuniculus) [TaxId: 9986]
223077 F:160-331Alpha and beta proteins (a+b)LDH C-terminal domain-likeLDH C-terminal domain-likeLactate & malate dehydrogenases, C-terminal domainautomated matchesRabbit (Oryctolagus cuniculus) [TaxId: 9986]
223078 G:1-159Alpha and beta proteins (a/b)NAD(P)-binding Rossmann-fold domainsNAD(P)-binding Rossmann-fold domainsLDH N-terminal domain-likeautomated matchesRabbit (Oryctolagus cuniculus) [TaxId: 9986]
223079 G:160-331Alpha and beta proteins (a+b)LDH C-terminal domain-likeLDH C-terminal domain-likeLactate & malate dehydrogenases, C-terminal domainautomated matchesRabbit (Oryctolagus cuniculus) [TaxId: 9986]
223080 H:1-159Alpha and beta proteins (a/b)NAD(P)-binding Rossmann-fold domainsNAD(P)-binding Rossmann-fold domainsLDH N-terminal domain-likeautomated matchesRabbit (Oryctolagus cuniculus) [TaxId: 9986]
223081 H:160-331Alpha and beta proteins (a+b)LDH C-terminal domain-likeLDH C-terminal domain-likeLactate & malate dehydrogenases, C-terminal domainautomated matchesRabbit (Oryctolagus cuniculus) [TaxId: 9986]

CATH
CATH ID Node Class Architecture Topology Homology
4i9uA013.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain
4i9uA023.90.110.10:Alpha-Beta Complex:L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2:Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
4i9uB013.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain
4i9uB023.90.110.10:Alpha-Beta Complex:L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2:Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
4i9uC013.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain
4i9uC023.90.110.10:Alpha-Beta Complex:L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2:Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
4i9uD013.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain
4i9uD023.90.110.10:Alpha-Beta Complex:L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2:Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
4i9uE013.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain
4i9uE023.90.110.10:Alpha-Beta Complex:L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2:Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
4i9uF013.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain
4i9uF023.90.110.10:Alpha-Beta Complex:L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2:Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
4i9uG013.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain
4i9uG023.90.110.10:Alpha-Beta Complex:L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2:Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
4i9uH013.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain
4i9uH023.90.110.10:Alpha-Beta Complex:L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2:Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal