PDB ID : 4l4r [A4]

Color

ARa IRb





 a AR:All Residues
 b IR:Interface Residues

Style





Secondary Structure


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Slab plane

Direction Proportion
From front %
From back %
Move slab

Chain
Chain name Ribbon Spacefill Cαonly
OLIGAMI PDB
AA
BH
CA
DH
Title
STRUCTURAL CHARACTERISATION OF THE APO-FORM OF HUMAN LACTATE DEHYDROGENASE M ISOZYME

Structure Summary
PDB ID Mutant OPM Pub Med Method/Resolution HETNAM
4l4r
24816116 X-RAY DIFFRACTION/2.1
Chain Formula
Amino Acid sequence SCOPe Family Level CATH Homology Level
[A4] [A4] [A4]

Structual Classification
SCOPe
SCOPe ID Chain Class Fold Superfamily Family Protein Domain Species
256977 A:1-159Alpha and beta proteins (a/b)NAD(P)-binding Rossmann-fold domainsNAD(P)-binding Rossmann-fold domainsLDH N-terminal domain-likeLactate dehydrogenaseHuman (Homo sapiens), muscle isoform (M chain) [TaxId: 9606]
256979 A:160-331Alpha and beta proteins (a+b)LDH C-terminal domain-likeLDH C-terminal domain-likeLactate & malate dehydrogenases, C-terminal domainLactate dehydrogenaseHuman (Homo sapiens), muscle isoform (M chain) [TaxId: 9606]
262899 H:1-159Alpha and beta proteins (a/b)NAD(P)-binding Rossmann-fold domainsNAD(P)-binding Rossmann-fold domainsLDH N-terminal domain-likeLactate dehydrogenaseHuman (Homo sapiens), muscle isoform (M chain) [TaxId: 9606]
262900 H:160-331Alpha and beta proteins (a+b)LDH C-terminal domain-likeLDH C-terminal domain-likeLactate & malate dehydrogenases, C-terminal domainLactate dehydrogenaseHuman (Homo sapiens), muscle isoform (M chain) [TaxId: 9606]

CATH
CATH ID Node Class Architecture Topology Homology
4l4rA013.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain
4l4rA023.90.110.10:Alpha-Beta Complex:L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2:Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
4l4rH013.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain
4l4rH023.90.110.10:Alpha-Beta Complex:L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2:Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal