OLIGAMI : Oligomer Architecture and Molecular Interface

PDB ID : 4nmh [A2]

Color

AR^a IR^b

Chain(OLIGAMI)
Chain(PDB)
Domain
CPK
Secondary Structure
Polar(blue)/
Nonpolar(white)

^a AR:All Residues
^b IR:Interface Residues

Style

Secondary Structure

Download

Slab plane

Direction	Proportion
From front	%
From back	%
Move slab

Chain

Chain name		Ribbon	Spacefill	Cαonly
OLIGAMI	PDB
A	A
B	B

Title

11-BETA-HSD1 IN COMPLEX WITH A 3,3-DI-METHYL-AZETIDIN-2-ONE

Structure Summary

PDB ID	Mutant	OPM	Pub Med	Method/Resolution	HETNAM
4nmh			Not in PubMed	X-RAY DIFFRACTION/2.9	2KG:(4S)-4-(2-METHOXYPHENYL)-3,3-DIMETHYL-1-[3-(METHYLSULFONYL)PHENYL]AZETIDIN-2-ONE NDP:NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDEPHOSPHATE SO4:SULFATE ION

Chain Formula
Amino Acid sequence	SCOPe Family Level	CATH Homology Level
[A2]	[A2]	[A2]

Interfaces

Interface ID	Chain	Inaterface Class	Interface Type	Contact Type
4nmh_AB	A B	HN HN	i7_CR(H35,N24)_HH(A1,S4)_HN(L3,S9) i7_CR(H35,N24)_HH(A1,S4)_HN(L3,S9)	c4_RP(HH52,NN42,HN39,NH36,EN1)_HH(P2,A3,S6)_HN(L8,S9) c4_RP(HH52,NN42,HN39,NH36,EN1)_HH(P2,A3,S6)_HN(L8,S9)

Interface Class

Interface ID	Interface 1						Interface 2
	Domain	Number of contact residues	Binding site Class	Percentages of Secondary structures(%)			Domain	Number of contact residues	Binding site Class	Percentages of Secondary structures(%)
	Domain	Number of contact residues	Binding site Class	H	E	N	Domain	Number of contact residues	Binding site Class	H	E	N
4nmh_AB	A	57	HN	52.6	100	47.4	B	57	HN	50.9	0	49.1

Interface Type: Information for each interface

Interface ID	chain	Number of contact residues			Number of elements					Number of contacts between Secondary structure elements
		Number of contact residues			Number of elements					HH			EE						HE			HN		EN
		Hn	En	Nn	H	E	N	R	L	P	A	S	P	A	S	Ph	Ah	Ih	P	A	S	L	S	L	S
4nmh_AB	A	30	57	27	6	0	7	0	0	0	0	4	0	0	0	0	0	0	0	0	0	3	10	0	0
4nmh_AB	B	29	0	28	6	0	7	0	0	0	0	3	0	0	0	0	0	0	0	0	0	2	12	0	0

Contact Type: Information of contacts between interfaces

Interface ID	Number of residue pairs between SS elements									Number of contacts between Secondary structure elements
	H-H	E-E	N-N	H-E	H-N	N-E	E-H	N-H	E-N	H-H				E-E					H-E				H-N			E-N
	H-H	E-E	N-N	H-E	H-N	N-E	E-H	N-H	E-N	P	A	S	Ih	P	A	S	IPh	IAh	P	A	S	Ih	L	S	Ih	L	S	Ih
4nmh_AB	45	0	37	0	36	0	0	35	0	0	3	7	0	0	0	0	0	0	0	0	0	0	8	8	0	0	0	0

Structual Classification

SCOPe

SCOPe ID	Chain	Class	Fold	Superfamily	Family	Protein Domain	Species
238031	A:	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Tyrosine-dependent oxidoreductases	11-beta-hydroxysteroid dehydrogenase 1	Mouse (Mus musculus) [TaxId: 10090]
238030	B:	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Tyrosine-dependent oxidoreductases	11-beta-hydroxysteroid dehydrogenase 1	Mouse (Mus musculus) [TaxId: 10090]
240636	C:	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Tyrosine-dependent oxidoreductases	11-beta-hydroxysteroid dehydrogenase 1	Mouse (Mus musculus) [TaxId: 10090]
240637	D:	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Tyrosine-dependent oxidoreductases	11-beta-hydroxysteroid dehydrogenase 1	Mouse (Mus musculus) [TaxId: 10090]

CATH

CATH ID	Node	Class	Architecture	Topology	Homology
4nmhA00	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
4nmhB00	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
4nmhC00	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
4nmhD00	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain