OLIGAMI : Oligomer Architecture and Molecular Interface

PDB ID : 4qo8 [A4]

Color

AR^a IR^b

Chain(OLIGAMI)
Chain(PDB)
Domain
CPK
Secondary Structure
Polar(blue)/
Nonpolar(white)

^a AR:All Residues
^b IR:Interface Residues

Style

Secondary Structure

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Slab plane

Direction	Proportion
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From back	%
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Chain

Chain name		Ribbon	Spacefill	Cαonly
OLIGAMI	PDB
A	A
B	B
C	C
D	D

Title

LACTATE DEHYDROGENASE A IN COMPLEX WITH SUBSTITUTED 3-HYDROXY-2- MERCAPTOCYCLOHEX-2-ENONE COMPOUND 104

Structure Summary

PDB ID	Mutant	OPM	Pub Med	Method/Resolution	HETNAM
4qo8			25037916	X-RAY DIFFRACTION/2	36U:(5S)-2-[(2-CHLOROPHENYL)SULFANYL]-5-(2,6-DICHLOROPHENYL)-3-HYDROXYCYCLOHEX-2-EN-1-ONE EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID LAC:LACTIC ACID NAI:1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE SO4:SULFATE ION

Chain Formula
Amino Acid sequence	SCOPe Family Level	CATH Homology Level
[A4]	[A4]	[A4]

Structual Classification

SCOPe

SCOPe ID	Chain	Class	Fold	Superfamily	Family	Protein Domain	Species
258491	A:1-159	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	LDH N-terminal domain-like	Lactate dehydrogenase	Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606]
258492	A:160-331	Alpha and beta proteins (a+b)	LDH C-terminal domain-like	LDH C-terminal domain-like	Lactate & malate dehydrogenases, C-terminal domain	Lactate dehydrogenase	Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606]
258487	B:1-159	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	LDH N-terminal domain-like	Lactate dehydrogenase	Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606]
258489	B:160-331	Alpha and beta proteins (a+b)	LDH C-terminal domain-like	LDH C-terminal domain-like	Lactate & malate dehydrogenases, C-terminal domain	Lactate dehydrogenase	Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606]
258503	C:1-159	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	LDH N-terminal domain-like	Lactate dehydrogenase	Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606]
258504	C:160-331	Alpha and beta proteins (a+b)	LDH C-terminal domain-like	LDH C-terminal domain-like	Lactate & malate dehydrogenases, C-terminal domain	Lactate dehydrogenase	Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606]
258505	D:1-159	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	LDH N-terminal domain-like	Lactate dehydrogenase	Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606]
258506	D:160-331	Alpha and beta proteins (a+b)	LDH C-terminal domain-like	LDH C-terminal domain-like	Lactate & malate dehydrogenases, C-terminal domain	Lactate dehydrogenase	Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606]

CATH

CATH ID	Node	Class	Architecture	Topology	Homology
4qo8A01	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
4qo8A02	3.90.110.10		:Alpha-Beta Complex	:L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2	:Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
4qo8B01	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
4qo8B02	3.90.110.10		:Alpha-Beta Complex	:L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2	:Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
4qo8C01	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
4qo8C02	3.90.110.10		:Alpha-Beta Complex	:L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2	:Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
4qo8D01	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
4qo8D02	3.90.110.10		:Alpha-Beta Complex	:L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2	:Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal