OLIGAMI : Oligomer Architecture and Molecular Interface

PDB ID : 4rls [A4]

Color

AR^a IR^b

Chain(OLIGAMI)
Chain(PDB)
Domain
CPK
Secondary Structure
Polar(blue)/
Nonpolar(white)

^a AR:All Residues
^b IR:Interface Residues

Style

Secondary Structure

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Slab plane

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Chain

Chain name		Ribbon	Spacefill	Cαonly
OLIGAMI	PDB
A	A
B	B
C	C
D	D

Title

LACTATE DEHYDROGENASE IN COMPLEX WITH INHIBITOR COMPOUND 47

Structure Summary

PDB ID	Mutant	OPM	Pub Med	Method/Resolution	HETNAM
4rls			25467161	X-RAY DIFFRACTION/1.91	2OP:(2S)-2-HYDROXYPROPANOIC ACID 49C:(1R)-5___sq___-[(2-CHLOROPHENYL)SULFANYL]-4___sq___-HYDROXY-2,3-DIHYDROSPIRO[INDENE-1,2___sq___-PYRAN]-6___sq___(3___sq___H)-ONE NAI:1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE SO4:SULFATE ION

Chain Formula
Amino Acid sequence	SCOPe Family Level	CATH Homology Level
[A4]	[A4]	[A4]

Structual Classification

SCOPe

SCOPe ID	Chain	Class	Fold	Superfamily	Family	Protein Domain	Species
260964	A:1-159	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	LDH N-terminal domain-like	Lactate dehydrogenase	Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606]
260965	A:160-331	Alpha and beta proteins (a+b)	LDH C-terminal domain-like	LDH C-terminal domain-like	Lactate & malate dehydrogenases, C-terminal domain	Lactate dehydrogenase	Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606]
260966	B:1-159	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	LDH N-terminal domain-like	Lactate dehydrogenase	Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606]
260968	B:160-331	Alpha and beta proteins (a+b)	LDH C-terminal domain-like	LDH C-terminal domain-like	Lactate & malate dehydrogenases, C-terminal domain	Lactate dehydrogenase	Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606]
260967	C:1-159	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	LDH N-terminal domain-like	Lactate dehydrogenase	Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606]
260969	C:160-331	Alpha and beta proteins (a+b)	LDH C-terminal domain-like	LDH C-terminal domain-like	Lactate & malate dehydrogenases, C-terminal domain	Lactate dehydrogenase	Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606]
260970	D:1-159	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	LDH N-terminal domain-like	Lactate dehydrogenase	Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606]
260971	D:160-331	Alpha and beta proteins (a+b)	LDH C-terminal domain-like	LDH C-terminal domain-like	Lactate & malate dehydrogenases, C-terminal domain	Lactate dehydrogenase	Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606]

CATH

CATH ID	Node	Architecture	Topology	Homology
4rlsA01	3.40.50.720	:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
4rlsA02	3.90.110.10	:Alpha-Beta Complex	:L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2	:Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
4rlsB01	3.40.50.720	:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
4rlsB02	3.90.110.10	:Alpha-Beta Complex	:L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2	:Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
4rlsC01	3.40.50.720	:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
4rlsC02	3.90.110.10	:Alpha-Beta Complex	:L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2	:Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
4rlsD01	3.40.50.720	:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
4rlsD02	3.90.110.10	:Alpha-Beta Complex	:L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2	:Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal