Title
CRYSTAL STRUCTURE OF HUMAN SEPIAPTERIN REDUCTASE IN COMPLEX WITH AN N- ACETYLSEROTININ ANALOGUE
Structure Summary
PDB ID |
Mutant |
OPM |
Pub Med |
Method/Resolution |
HETNAM |
4xwy |
|
|
26087165 |
X-RAY DIFFRACTION/2.35 |
43O:N-[2-(5-HYDROXY-2-METHYL-1H-INDOL-3-YL)ETHYL]-2-METHOXYACETAMIDE NDP:NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDEPHOSPHATE SO4:SULFATE ION
|
Chain Formula |
Amino Acid sequence |
SCOPe Family Level |
CATH Homology Level |
[A2] |
[A2] |
[A2] |
Interfaces
Interface ID |
Chain |
Inaterface Class |
Interface Type |
Contact Type |
4xwy_AB |
A B |
HN
HN |
i15_CR(H13,N13)_HH(S2)_HN(L1,S5)
i15_CR(H13,N13)_HH(S2)_HN(L1,S5)
|
c8_RP(HH15,NN15,HN24,NH22)_HH(A1,S2)_HN(L6,S4)
c8_RP(HH15,NN15,HN24,NH22)_HH(A1,S2)_HN(L6,S4)
|
Interface Class
Interface ID |
Interface 1 |
Interface 2 |
Domain |
Number of contact residues |
Binding site Class |
Percentages of Secondary structures(%) |
Domain |
Number of contact residues |
Binding site Class |
Percentages of Secondary structures(%) |
H |
E |
N |
H |
E |
N |
4xwy_AB |
A |
46 |
HN |
58.7 |
100 |
41.3 |
B |
46 |
HN |
60.9 |
0 |
39.1 |
Interface Type: Information for each interface
Interface ID |
chain |
Number of contact residues |
Number of elements |
Number of contacts between Secondary structure elements |
HH |
EE |
HE |
HN |
EN |
Hn |
En |
Nn |
H |
E |
N |
R |
L |
P |
A |
S |
P |
A |
S |
Ph |
Ah |
Ih |
P |
A |
S |
L |
S |
L |
S |
4xwy_AB |
A |
27 |
46 |
19 |
4 |
0 |
4 |
0 |
0 |
0 |
0 |
3 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
2 |
5 |
0 |
0 |
4xwy_AB |
B |
28 |
0 |
18 |
4 |
0 |
4 |
0 |
0 |
0 |
0 |
3 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
2 |
5 |
0 |
0 |
Contact Type: Information of contacts between interfaces
Interface ID |
Number of residue pairs between SS elements |
Number of contacts between Secondary structure elements |
H-H |
E-E |
N-N |
H-E |
H-N |
N-E |
E-H |
N-H |
E-N |
H-H |
E-E |
H-E |
H-N |
E-N |
P |
A |
S |
Ih |
P |
A |
S |
IPh |
IAh |
P |
A |
S |
Ih |
L |
S |
Ih |
L |
S |
Ih |
4xwy_AB |
39 |
0 |
3 |
0 |
39 |
0 |
0 |
37 |
0 |
0 |
4 |
4 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
8 |
0 |
0 |
0 |
0 |
0 |
Structual Classification
SCOPe
CATH