OLIGAMI : Oligomer Architecture and Molecular Interface

PDB ID : 5c37 [A]

Color

AR^a IR^b

Chain(OLIGAMI)
Chain(PDB)
Domain
CPK
Secondary Structure
Polar(blue)/
Nonpolar(white)

^a AR:All Residues
^b IR:Interface Residues

Style

Secondary Structure

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Chain

Chain name		Ribbon	Spacefill	Cαonly
OLIGAMI	PDB
A	A

Title

STRUCTURE OF THE BETA-KETOACYL REDUCTASE DOMAIN OF HUMAN FATTY ACID SYNTHASE BOUND TO A SPIRO-IMIDAZOLONE INHIBITOR

Structure Summary

PDB ID	Mutant	OPM	Pub Med	Method/Resolution	HETNAM
5c37			Not in PubMed	X-RAY DIFFRACTION/2.3	4XN:6-{[(3R)-1-(CYCLOPROPYLCARBONYL)PYRROLIDIN-3-YL]METHYL}-5-[4-(1-METHYL-1H-INDAZOL-5-YL)PHENYL]-4,6-DIAZASPIRO[2.4]HEPT-4-EN-7-ONE CL:CHLORIDE ION GOL:GLYCEROL NDP:NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDEPHOSPHATE

Chain Formula
Amino Acid sequence	SCOPe Family Level	CATH Homology Level
[A]	[A]	[A]

Structual Classification

SCOPe

SCOPe ID	Chain	Class	Fold	Superfamily	Family	Protein Domain	Species
414607	A:1108-1406	Alpha and beta proteins (a/b)	S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	automated matches	automated matches	Human (Homo sapiens) [TaxId: 9606]
414608	A:1407-1522	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	automated matches	automated matches	Human (Homo sapiens) [TaxId: 9606]
414609	A:1877-2113	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	automated matches	automated matches	Human (Homo sapiens) [TaxId: 9606]
414610	C:1108-1406	Alpha and beta proteins (a/b)	S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	automated matches	automated matches	Human (Homo sapiens) [TaxId: 9606]
414611	C:1407-1522	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	automated matches	automated matches	Human (Homo sapiens) [TaxId: 9606]
414612	C:1877-2114	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	automated matches	automated matches	Human (Homo sapiens) [TaxId: 9606]

CATH

CATH ID	Node	Class	Architecture	Topology	Homology
5c37A02	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain
5c37C02	3.40.50.720		:3-Layer(aba) Sandwich	:Rossmann fold	:NAD(P)-binding Rossmann-like Domain