PDB ID : 5in4 [A4]

Color

ARa IRb





 a AR:All Residues
 b IR:Interface Residues

Style





Secondary Structure


Download

Slab plane

Direction Proportion
From front %
From back %
Move slab

Chain
Chain name Ribbon Spacefill Cαonly
OLIGAMI PDB
AA
BB
CC
DD
Title
CRYSTAL STRUCTURE OF GDP-MANNOSE 4,6 DEHYDRATASE BOUND TO A GDP-FUCOSE BASED INHIBITOR

Structure Summary
PDB ID Mutant OPM Pub Med Method/Resolution HETNAM
5in4
27434622 X-RAY DIFFRACTION/1.6 6CK:[(2R,3S,4R,5R)-5-(2-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL (2R,3S,4R,5S,6R)-3,4,5-TRIHYDROXY-6-(TRIFLUOROMETHYL)TETRAHYDRO-2H-PYRAN-2-YL DIHYDROGEN DIPHOSPHATE (NON-PREFERRED NAME)
GDP:GUANOSINE-5___sq___-DIPHOSPHATE
NAP:NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Chain Formula
Amino Acid sequence SCOPe Family Level CATH Homology Level
[A4] [A4] [A4]

Structual Classification
SCOPe
SCOPe ID Chain Class Fold Superfamily Family Protein Domain Species
321380 A:-26--22ArtifactsTagsTagsTagsN-terminal TagsSynthetic
321379 A:23-372Alpha and beta proteins (a/b)NAD(P)-binding Rossmann-fold domainsNAD(P)-binding Rossmann-fold domainsTyrosine-dependent oxidoreductasesGDP-mannose 4,6-dehydrataseHuman (Homo sapiens) [TaxId: 9606]
321324 B:-22--22ArtifactsTagsTagsTagsN-terminal TagsSynthetic
321323 B:23-372Alpha and beta proteins (a/b)NAD(P)-binding Rossmann-fold domainsNAD(P)-binding Rossmann-fold domainsTyrosine-dependent oxidoreductasesGDP-mannose 4,6-dehydrataseHuman (Homo sapiens) [TaxId: 9606]
321314 C:-22--22ArtifactsTagsTagsTagsN-terminal TagsSynthetic
321313 C:23-372Alpha and beta proteins (a/b)NAD(P)-binding Rossmann-fold domainsNAD(P)-binding Rossmann-fold domainsTyrosine-dependent oxidoreductasesGDP-mannose 4,6-dehydrataseHuman (Homo sapiens) [TaxId: 9606]
321316 D:-22--22ArtifactsTagsTagsTagsN-terminal TagsSynthetic
321315 D:23-372Alpha and beta proteins (a/b)NAD(P)-binding Rossmann-fold domainsNAD(P)-binding Rossmann-fold domainsTyrosine-dependent oxidoreductasesGDP-mannose 4,6-dehydrataseHuman (Homo sapiens) [TaxId: 9606]

CATH
CATH ID Node Class Architecture Topology Homology
5in4A013.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain
5in4A023.90.25.10:Alpha-Beta Complex:UDP-galactose 4-epimerase; domain 1:UDP-galactose 4-epimerase, domain 1
5in4B013.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain
5in4B023.90.25.10:Alpha-Beta Complex:UDP-galactose 4-epimerase; domain 1:UDP-galactose 4-epimerase, domain 1
5in4C013.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain
5in4C023.90.25.10:Alpha-Beta Complex:UDP-galactose 4-epimerase; domain 1:UDP-galactose 4-epimerase, domain 1
5in4D013.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain
5in4D023.90.25.10:Alpha-Beta Complex:UDP-galactose 4-epimerase; domain 1:UDP-galactose 4-epimerase, domain 1