PDB ID : 5ofw [A2]
Color
ARa IRb
|
|
a AR:All Residues
b IR:Interface Residues
b IR:Interface Residues
Slab plane
Title
CRYSTAL STRUCTURE OF HUMAN 3-PHOSPHOGLYCERATE DEHYDROGENASE IN COMPLEX WITH 3-CHLORO-4-FLUOROBENZAMIDE
Structure Summary
| PDB ID | Mutant | OPM | Pub Med | Method/Resolution | HETNAM |
|---|---|---|---|---|---|
| 5ofw | 29568346 | X-RAY DIFFRACTION/1.5 | 9TW:3-CHLORANYL-4-FLUORANYL-BENZAMIDE |
| Chain Formula | ||
|---|---|---|
| Amino Acid sequence | SCOPe Family Level | CATH Homology Level |
| [A2] | [A2] | [A2] |
Interfaces
| Interface ID | Chain | Inaterface Class |
Interface Type | Contact Type |
|---|---|---|---|---|
| 5ofw_AB | A B |
HEN HEN |
i12_CR(H17,E4,N10)_CE(H4,E2,N4,C1)_HH(S1)_HE(S2)_HN(L1,S5)_EN(S2) i16_CR(H18,E4,N22)_CE(H4,E2,N6)_HH(P1,S1)_HE(S1)_HN(L1,S5)_EN(S4) |
c3_RP(HH19,NN27,HE7,HN22,NE2,EH10,NH24,EN2)_HH(P1,A1,S2)_HE(P1,A1,S3)_HN(L5,S7)_EN(S2) c3_RP(HH36,NN33,HE3,HN33,NE2,EH3,NH32,EN3)_HH(P2,A2,S4)_HE(P1)_HN(L8,S8)_EN(S3) |
Interface Class
| Interface ID | Interface 1 | Interface 2 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Domain | Number of contact residues | Binding site Class | Percentages of Secondary structures(%) | Domain | Number of contact residues | Binding site Class | Percentages of Secondary structures(%) | |||||
| H | E | N | H | E | N | |||||||
| 5ofw_AB | A | 54 | HEN | 46.3 | 100 | 48.1 | B | 55 | HEN | 45.5 | 5.5 | 49.1 |
Interface Type: Information for each interface
| Interface ID | chain | Number of contact residues | Number of elements | Number of contacts between Secondary structure elements | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HH | EE | HE | HN | EN | |||||||||||||||||||||
| Hn | En | Nn | H | E | N | R | L | P | A | S | P | A | S | Ph | Ah | Ih | P | A | S | L | S | L | S | ||
| 5ofw_AB | A | 25 | 54 | 26 | 5 | 1 | 5 | 1 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 5 | 3 | 0 | 3 |
| 5ofw_AB | B | 25 | 3 | 27 | 5 | 1 | 5 | 1 | 0 | 1 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 5 | 3 | 0 | 3 |
Contact Type: Information of contacts between interfaces
| Interface ID | Number of residue pairs between SS elements | Number of contacts between Secondary structure elements | ||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| H-H | E-E | N-N | H-E | H-N | N-E | E-H | N-H | E-N | H-H | E-E | H-E | H-N | E-N | |||||||||||||||
| P | A | S | Ih | P | A | S | IPh | IAh | P | A | S | Ih | L | S | Ih | L | S | Ih | ||||||||||
| 5ofw_AB | 36 | 0 | 42 | 7 | 34 | 0 | 7 | 35 | 0 | 3 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 7 | 9 | 2 | 0 | 0 | 0 |
Structual Classification
SCOPe
| SCOPe ID | Chain | Class | Fold | Superfamily | Family | Protein Domain | Species |
|---|---|---|---|---|---|---|---|
| x76835 | _ | Not Classified | Not Classified 768 | Not Classified 768 | Not Classified 768 | Not Classified 768 | Not Classified 76835 |
CATH
| CATH ID | Node | Class | Architecture | Topology | Homology |
|---|---|---|---|---|---|
| 5ofwA00 | 3.40.50.720 | :3-Layer(aba) Sandwich | :Rossmann fold | :NAD(P)-binding Rossmann-like Domain | |
| 5ofwB00 | 3.40.50.720 | :3-Layer(aba) Sandwich | :Rossmann fold | :NAD(P)-binding Rossmann-like Domain |
