Title
LACTATE DEHYDROGENASE IN COMPLEX WITH INHIBITOR (R)-3-((2- CHLOROPHENYL)THIO)-6-(3-((4-FLUOROPHENYL)AMINO)PHENYL)-4-HYDROXY-6- (THIOPHEN-3-YL)-5,6-DIHYDRO-2H-PYRAN-2-ONE
Structure Summary
| PDB ID |
Mutant |
OPM |
Pub Med |
Method/Resolution |
HETNAM |
|
6bad |
|
|
Not in PubMed |
X-RAY DIFFRACTION/2.1 |
D0Y:(6R)-3-[(2-CHLOROPHENYL)SULFANYL]-6-{3-[(4-FLUOROPHENYL)AMINO]PHENYL}-4-HYDROXY-6-(THIOPHEN-3-YL)-5,6-DIHYDRO-2H-PYRAN-2-ONE
EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE
SO4:SULFATE ION
|
| Chain Formula |
| Amino Acid sequence |
SCOPe Family Level |
CATH Homology Level |
| [A4] |
[A4] |
[A4] |
Structual Classification
SCOPe
| SCOPe ID |
Chain |
Class |
Fold |
Superfamily |
Family |
Protein Domain |
Species |
| 358836 | A:1-159 | Alpha and beta proteins (a/b) | NAD(P)-binding Rossmann-fold domains | NAD(P)-binding Rossmann-fold domains | LDH N-terminal domain-like | Lactate dehydrogenase | Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606] |
| 358837 | A:160-331 | Alpha and beta proteins (a+b) | LDH C-terminal domain-like | LDH C-terminal domain-like | Lactate & malate dehydrogenases, C-terminal domain | Lactate dehydrogenase | Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606] |
| 358815 | B:1-159 | Alpha and beta proteins (a/b) | NAD(P)-binding Rossmann-fold domains | NAD(P)-binding Rossmann-fold domains | LDH N-terminal domain-like | Lactate dehydrogenase | Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606] |
| 358816 | B:160-331 | Alpha and beta proteins (a+b) | LDH C-terminal domain-like | LDH C-terminal domain-like | Lactate & malate dehydrogenases, C-terminal domain | Lactate dehydrogenase | Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606] |
| 358960 | C:1-159 | Alpha and beta proteins (a/b) | NAD(P)-binding Rossmann-fold domains | NAD(P)-binding Rossmann-fold domains | LDH N-terminal domain-like | Lactate dehydrogenase | Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606] |
| 358961 | C:160-331 | Alpha and beta proteins (a+b) | LDH C-terminal domain-like | LDH C-terminal domain-like | Lactate & malate dehydrogenases, C-terminal domain | Lactate dehydrogenase | Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606] |
| 358827 | D:1-159 | Alpha and beta proteins (a/b) | NAD(P)-binding Rossmann-fold domains | NAD(P)-binding Rossmann-fold domains | LDH N-terminal domain-like | Lactate dehydrogenase | Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606] |
| 358828 | D:160-331 | Alpha and beta proteins (a+b) | LDH C-terminal domain-like | LDH C-terminal domain-like | Lactate & malate dehydrogenases, C-terminal domain | Lactate dehydrogenase | Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606] |
CATH
| CATH ID |
Node |
Class |
Architecture |
Topology |
Homology |
| 6badA01 | 3.40.50.720 | | :3-Layer(aba) Sandwich | :Rossmann fold | :NAD(P)-binding Rossmann-like Domain |
| 6badA02 | 3.90.110.10 | | :Alpha-Beta Complex | :L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2 | :Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal |
| 6badB01 | 3.40.50.720 | | :3-Layer(aba) Sandwich | :Rossmann fold | :NAD(P)-binding Rossmann-like Domain |
| 6badB02 | 3.90.110.10 | | :Alpha-Beta Complex | :L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2 | :Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal |
| 6badC01 | 3.40.50.720 | | :3-Layer(aba) Sandwich | :Rossmann fold | :NAD(P)-binding Rossmann-like Domain |
| 6badC02 | 3.90.110.10 | | :Alpha-Beta Complex | :L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2 | :Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal |
| 6badD01 | 3.40.50.720 | | :3-Layer(aba) Sandwich | :Rossmann fold | :NAD(P)-binding Rossmann-like Domain |
| 6badD02 | 3.90.110.10 | | :Alpha-Beta Complex | :L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2 | :Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal |
