Title
LACTATE DEHYDROGENASE IN COMPLEX WITH INHIBITOR (R)-5-((2- CHLOROPHENYL)THIO)-6___sq___-((4-FLUOROPHENYL)AMINO)-4-HYDROXY-2-(THIOPHEN- 3-YL)-2,3-DIHYDRO-[2,2___sq___-BIPYRIDIN]-6(1H)-ONE
Structure Summary
PDB ID |
Mutant |
OPM |
Pub Med |
Method/Resolution |
HETNAM |
6bag |
|
|
Not in PubMed |
X-RAY DIFFRACTION/2.4 |
D0V:(2R)-5-[(2-CHLOROPHENYL)SULFANYL]-6___sq___-[(4-FLUOROPHENYL)AMINO]-4-HYDROXY-2-(THIOPHEN-3-YL)-2,3-DIHYDRO[2,2___sq___-BIPYRIDIN]-6(1H)-ONE EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE SO4:SULFATE ION
|
Chain Formula |
Amino Acid sequence |
SCOPe Family Level |
CATH Homology Level |
[A4] |
[A4] |
[A4] |
Structual Classification
SCOPe
SCOPe ID |
Chain |
Class |
Fold |
Superfamily |
Family |
Protein Domain |
Species |
359102 | A:1-159 | Alpha and beta proteins (a/b) | NAD(P)-binding Rossmann-fold domains | NAD(P)-binding Rossmann-fold domains | LDH N-terminal domain-like | Lactate dehydrogenase | Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606] |
359103 | A:160-331 | Alpha and beta proteins (a+b) | LDH C-terminal domain-like | LDH C-terminal domain-like | Lactate & malate dehydrogenases, C-terminal domain | Lactate dehydrogenase | Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606] |
358819 | B:1-159 | Alpha and beta proteins (a/b) | NAD(P)-binding Rossmann-fold domains | NAD(P)-binding Rossmann-fold domains | LDH N-terminal domain-like | Lactate dehydrogenase | Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606] |
358821 | B:160-331 | Alpha and beta proteins (a+b) | LDH C-terminal domain-like | LDH C-terminal domain-like | Lactate & malate dehydrogenases, C-terminal domain | Lactate dehydrogenase | Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606] |
358849 | C:1-159 | Alpha and beta proteins (a/b) | NAD(P)-binding Rossmann-fold domains | NAD(P)-binding Rossmann-fold domains | LDH N-terminal domain-like | Lactate dehydrogenase | Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606] |
358850 | C:160-331 | Alpha and beta proteins (a+b) | LDH C-terminal domain-like | LDH C-terminal domain-like | Lactate & malate dehydrogenases, C-terminal domain | Lactate dehydrogenase | Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606] |
358818 | D:1-159 | Alpha and beta proteins (a/b) | NAD(P)-binding Rossmann-fold domains | NAD(P)-binding Rossmann-fold domains | LDH N-terminal domain-like | Lactate dehydrogenase | Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606] |
358820 | D:160-331 | Alpha and beta proteins (a+b) | LDH C-terminal domain-like | LDH C-terminal domain-like | Lactate & malate dehydrogenases, C-terminal domain | Lactate dehydrogenase | Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606] |
CATH
CATH ID |
Node |
Class |
Architecture |
Topology |
Homology |
6bagA01 | 3.40.50.720 | | :3-Layer(aba) Sandwich | :Rossmann fold | :NAD(P)-binding Rossmann-like Domain |
6bagA02 | 3.90.110.10 | | :Alpha-Beta Complex | :L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2 | :Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal |
6bagB01 | 3.40.50.720 | | :3-Layer(aba) Sandwich | :Rossmann fold | :NAD(P)-binding Rossmann-like Domain |
6bagB02 | 3.90.110.10 | | :Alpha-Beta Complex | :L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2 | :Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal |
6bagC01 | 3.40.50.720 | | :3-Layer(aba) Sandwich | :Rossmann fold | :NAD(P)-binding Rossmann-like Domain |
6bagC02 | 3.90.110.10 | | :Alpha-Beta Complex | :L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2 | :Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal |
6bagD01 | 3.40.50.720 | | :3-Layer(aba) Sandwich | :Rossmann fold | :NAD(P)-binding Rossmann-like Domain |
6bagD02 | 3.90.110.10 | | :Alpha-Beta Complex | :L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2 | :Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal |