PDB ID : 6bax [A4]

Color

ARa IRb





 a AR:All Residues
 b IR:Interface Residues

Style





Secondary Structure


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Slab plane

Direction Proportion
From front %
From back %
Move slab

Chain
Chain name Ribbon Spacefill Cαonly
OLIGAMI PDB
AA
BB
CC
DD
Title
LACTATE DEHYDROGENASE IN COMPLEX WITH INHIBITOR 6-(3-AMINOPHENYL)-3- ((2-CHLOROPHENYL)THIO)-4-HYDROXY-6-(THIOPHEN-3-YL)-5,6-DIHYDRO-2H- PYRAN-2-ONE

Structure Summary
PDB ID Mutant OPM Pub Med Method/Resolution HETNAM
6bax
Not in PubMed X-RAY DIFFRACTION/2.05 D4S:(6R)-6-(3-AMINOPHENYL)-3-[(2-CHLOROPHENYL)SULFANYL]-4-HYDROXY-6-(THIOPHEN-3-YL)-5,6-DIHYDRO-2H-PYRAN-2-ONE
EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE
SO4:SULFATE ION
Chain Formula
Amino Acid sequence SCOPe Family Level CATH Homology Level
[A4] [A4] [A4]

Structual Classification
SCOPe
SCOPe ID Chain Class Fold Superfamily Family Protein Domain Species
359166 A:1-159Alpha and beta proteins (a/b)NAD(P)-binding Rossmann-fold domainsNAD(P)-binding Rossmann-fold domainsLDH N-terminal domain-likeLactate dehydrogenaseHuman (Homo sapiens), muscle isoform (M chain) [TaxId: 9606]
359167 A:160-331Alpha and beta proteins (a+b)LDH C-terminal domain-likeLDH C-terminal domain-likeLactate & malate dehydrogenases, C-terminal domainLactate dehydrogenaseHuman (Homo sapiens), muscle isoform (M chain) [TaxId: 9606]
359484 B:1-159Alpha and beta proteins (a/b)NAD(P)-binding Rossmann-fold domainsNAD(P)-binding Rossmann-fold domainsLDH N-terminal domain-likeLactate dehydrogenaseHuman (Homo sapiens), muscle isoform (M chain) [TaxId: 9606]
359485 B:160-331Alpha and beta proteins (a+b)LDH C-terminal domain-likeLDH C-terminal domain-likeLactate & malate dehydrogenases, C-terminal domainLactate dehydrogenaseHuman (Homo sapiens), muscle isoform (M chain) [TaxId: 9606]
359111 C:1-159Alpha and beta proteins (a/b)NAD(P)-binding Rossmann-fold domainsNAD(P)-binding Rossmann-fold domainsLDH N-terminal domain-likeLactate dehydrogenaseHuman (Homo sapiens), muscle isoform (M chain) [TaxId: 9606]
359112 C:160-331Alpha and beta proteins (a+b)LDH C-terminal domain-likeLDH C-terminal domain-likeLactate & malate dehydrogenases, C-terminal domainLactate dehydrogenaseHuman (Homo sapiens), muscle isoform (M chain) [TaxId: 9606]
359475 D:1-159Alpha and beta proteins (a/b)NAD(P)-binding Rossmann-fold domainsNAD(P)-binding Rossmann-fold domainsLDH N-terminal domain-likeLactate dehydrogenaseHuman (Homo sapiens), muscle isoform (M chain) [TaxId: 9606]
359476 D:160-331Alpha and beta proteins (a+b)LDH C-terminal domain-likeLDH C-terminal domain-likeLactate & malate dehydrogenases, C-terminal domainLactate dehydrogenaseHuman (Homo sapiens), muscle isoform (M chain) [TaxId: 9606]

CATH
CATH ID Node Class Architecture Topology Homology
6baxA013.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain
6baxA023.90.110.10:Alpha-Beta Complex:L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2:Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
6baxB013.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain
6baxB023.90.110.10:Alpha-Beta Complex:L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2:Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
6baxC013.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain
6baxC023.90.110.10:Alpha-Beta Complex:L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2:Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
6baxD013.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain
6baxD023.90.110.10:Alpha-Beta Complex:L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2:Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal