Title
LACTATE DEHYDROGENASE IN COMPLEX WITH INHIBITOR (S)-5-((2- CHLOROPHENYL)THIO)-6___sq___-((4-FLUOROPHENYL)AMINO)-4-HYDROXY-2-(THIOPHEN- 3-YL)-2,3-DIHYDRO-[2,2___sq___-BIPYRIDIN]-6(1H)-ONE
Structure Summary
| PDB ID |
Mutant |
OPM |
Pub Med |
Method/Resolution |
HETNAM |
|
6baz |
|
|
Not in PubMed |
X-RAY DIFFRACTION/2.7 |
D47:(3S,6S)-3-[(2-CHLOROPHENYL)SULFANYL]-6-{6-[(4-FLUOROPHENYL)AMINO]PYRIDIN-2-YL}-6-(THIOPHEN-3-YL)PIPERIDINE-2,4-DIONE
EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
LAC:LACTIC ACID
NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE
SO4:SULFATE ION
|
| Chain Formula |
| Amino Acid sequence |
SCOPe Family Level |
CATH Homology Level |
| [A4] |
[A4] |
[A4] |
Structual Classification
SCOPe
| SCOPe ID |
Chain |
Class |
Fold |
Superfamily |
Family |
Protein Domain |
Species |
| 359131 | A:1-159 | Alpha and beta proteins (a/b) | NAD(P)-binding Rossmann-fold domains | NAD(P)-binding Rossmann-fold domains | LDH N-terminal domain-like | Lactate dehydrogenase | Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606] |
| 359133 | A:160-331 | Alpha and beta proteins (a+b) | LDH C-terminal domain-like | LDH C-terminal domain-like | Lactate & malate dehydrogenases, C-terminal domain | Lactate dehydrogenase | Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606] |
| 359136 | B:1-159 | Alpha and beta proteins (a/b) | NAD(P)-binding Rossmann-fold domains | NAD(P)-binding Rossmann-fold domains | LDH N-terminal domain-like | Lactate dehydrogenase | Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606] |
| 359137 | B:160-331 | Alpha and beta proteins (a+b) | LDH C-terminal domain-like | LDH C-terminal domain-like | Lactate & malate dehydrogenases, C-terminal domain | Lactate dehydrogenase | Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606] |
| 359124 | C:1-159 | Alpha and beta proteins (a/b) | NAD(P)-binding Rossmann-fold domains | NAD(P)-binding Rossmann-fold domains | LDH N-terminal domain-like | Lactate dehydrogenase | Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606] |
| 359125 | C:160-331 | Alpha and beta proteins (a+b) | LDH C-terminal domain-like | LDH C-terminal domain-like | Lactate & malate dehydrogenases, C-terminal domain | Lactate dehydrogenase | Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606] |
| 359480 | D:1-159 | Alpha and beta proteins (a/b) | NAD(P)-binding Rossmann-fold domains | NAD(P)-binding Rossmann-fold domains | LDH N-terminal domain-like | Lactate dehydrogenase | Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606] |
| 359481 | D:160-331 | Alpha and beta proteins (a+b) | LDH C-terminal domain-like | LDH C-terminal domain-like | Lactate & malate dehydrogenases, C-terminal domain | Lactate dehydrogenase | Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606] |
CATH
| CATH ID |
Node |
Class |
Architecture |
Topology |
Homology |
| 6bazA01 | 3.40.50.720 | | :3-Layer(aba) Sandwich | :Rossmann fold | :NAD(P)-binding Rossmann-like Domain |
| 6bazA02 | 3.90.110.10 | | :Alpha-Beta Complex | :L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2 | :Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal |
| 6bazB01 | 3.40.50.720 | | :3-Layer(aba) Sandwich | :Rossmann fold | :NAD(P)-binding Rossmann-like Domain |
| 6bazB02 | 3.90.110.10 | | :Alpha-Beta Complex | :L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2 | :Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal |
| 6bazC01 | 3.40.50.720 | | :3-Layer(aba) Sandwich | :Rossmann fold | :NAD(P)-binding Rossmann-like Domain |
| 6bazC02 | 3.90.110.10 | | :Alpha-Beta Complex | :L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2 | :Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal |
| 6bazD01 | 3.40.50.720 | | :3-Layer(aba) Sandwich | :Rossmann fold | :NAD(P)-binding Rossmann-like Domain |
| 6bazD02 | 3.90.110.10 | | :Alpha-Beta Complex | :L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2 | :Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal |
