Title
LACTATE DEHYDROGENASE IN COMPLEX WITH INHIBITOR (R)-3-((2- CHLOROPHENYL)THIO)-6-(3-((4-FLUOROPHENYL)AMINO)PHENYL)-4-HYDROXY-6- (THIOPHEN-3-YL)-5,6-DIHYDRO-2H-PYRAN-2-ONE
Structure Summary
PDB ID |
Mutant |
OPM |
Pub Med |
Method/Resolution |
HETNAM |
6bb0 |
|
|
Not in PubMed |
X-RAY DIFFRACTION/1.95 |
D3S:(6S)-3-[(2-CHLOROPHENYL)SULFANYL]-4-HYDROXY-6-(2-HYDROXYPHENYL)-6-PHENYL-5,6-DIHYDRO-2H-PYRAN-2-ONE EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID LAC:LACTIC ACID NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE SO4:SULFATE ION
|
Chain Formula |
Amino Acid sequence |
SCOPe Family Level |
CATH Homology Level |
[A4] |
[A4] |
[A4] |
Structual Classification
SCOPe
SCOPe ID |
Chain |
Class |
Fold |
Superfamily |
Family |
Protein Domain |
Species |
359301 | A:1-159 | Alpha and beta proteins (a/b) | NAD(P)-binding Rossmann-fold domains | NAD(P)-binding Rossmann-fold domains | LDH N-terminal domain-like | Lactate dehydrogenase | Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606] |
359302 | A:160-331 | Alpha and beta proteins (a+b) | LDH C-terminal domain-like | LDH C-terminal domain-like | Lactate & malate dehydrogenases, C-terminal domain | Lactate dehydrogenase | Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606] |
359176 | B:1-159 | Alpha and beta proteins (a/b) | NAD(P)-binding Rossmann-fold domains | NAD(P)-binding Rossmann-fold domains | LDH N-terminal domain-like | Lactate dehydrogenase | Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606] |
359177 | B:160-331 | Alpha and beta proteins (a+b) | LDH C-terminal domain-like | LDH C-terminal domain-like | Lactate & malate dehydrogenases, C-terminal domain | Lactate dehydrogenase | Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606] |
359156 | C:1-159 | Alpha and beta proteins (a/b) | NAD(P)-binding Rossmann-fold domains | NAD(P)-binding Rossmann-fold domains | LDH N-terminal domain-like | Lactate dehydrogenase | Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606] |
359157 | C:160-331 | Alpha and beta proteins (a+b) | LDH C-terminal domain-like | LDH C-terminal domain-like | Lactate & malate dehydrogenases, C-terminal domain | Lactate dehydrogenase | Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606] |
359122 | D:1-159 | Alpha and beta proteins (a/b) | NAD(P)-binding Rossmann-fold domains | NAD(P)-binding Rossmann-fold domains | LDH N-terminal domain-like | Lactate dehydrogenase | Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606] |
359123 | D:160-331 | Alpha and beta proteins (a+b) | LDH C-terminal domain-like | LDH C-terminal domain-like | Lactate & malate dehydrogenases, C-terminal domain | Lactate dehydrogenase | Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606] |
CATH
CATH ID |
Node |
Class |
Architecture |
Topology |
Homology |
6bb0A01 | 3.40.50.720 | | :3-Layer(aba) Sandwich | :Rossmann fold | :NAD(P)-binding Rossmann-like Domain |
6bb0A02 | 3.90.110.10 | | :Alpha-Beta Complex | :L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2 | :Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal |
6bb0B01 | 3.40.50.720 | | :3-Layer(aba) Sandwich | :Rossmann fold | :NAD(P)-binding Rossmann-like Domain |
6bb0B02 | 3.90.110.10 | | :Alpha-Beta Complex | :L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2 | :Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal |
6bb0C01 | 3.40.50.720 | | :3-Layer(aba) Sandwich | :Rossmann fold | :NAD(P)-binding Rossmann-like Domain |
6bb0C02 | 3.90.110.10 | | :Alpha-Beta Complex | :L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2 | :Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal |
6bb0D01 | 3.40.50.720 | | :3-Layer(aba) Sandwich | :Rossmann fold | :NAD(P)-binding Rossmann-like Domain |
6bb0D02 | 3.90.110.10 | | :Alpha-Beta Complex | :L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2 | :Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal |