PDB ID : 6bb3 [A4]

Color

ARa IRb





 a AR:All Residues
 b IR:Interface Residues

Style





Secondary Structure


Download

Slab plane

Direction Proportion
From front %
From back %
Move slab

Chain
Chain name Ribbon Spacefill Cαonly
OLIGAMI PDB
AA
BB
CC
DD
Title
LACTATE DEHYDROGENASE IN COMPLEX WITH INHIBITOR 3-((2-CHLOROPHENYL) THIO)-6-(6-((4-FLUOROPHENYL)AMINO)PYRIDIN-2-YL)-4-HYDROXY-6- (THIOPHEN-3-YL)-5,6-DIHYDRO-2H-PYRAN-2-ONE

Structure Summary
PDB ID Mutant OPM Pub Med Method/Resolution HETNAM
6bb3
Not in PubMed X-RAY DIFFRACTION/2.4 D4A:(6R)-3-[(2-CHLOROPHENYL)SULFANYL]-6-{6-[(4-FLUOROPHENYL)AMINO]PYRIDIN-2-YL}-4-HYDROXY-6-(THIOPHEN-3-YL)-5,6-DIHYDRO-2H-PYRAN-2-ONE
NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE
SO4:SULFATE ION
Chain Formula
Amino Acid sequence SCOPe Family Level CATH Homology Level
[A4] [A4] [A4]

Structual Classification
SCOPe
SCOPe ID Chain Class Fold Superfamily Family Protein Domain Species
359130 A:1-159Alpha and beta proteins (a/b)NAD(P)-binding Rossmann-fold domainsNAD(P)-binding Rossmann-fold domainsLDH N-terminal domain-likeLactate dehydrogenaseHuman (Homo sapiens), muscle isoform (M chain) [TaxId: 9606]
359132 A:160-331Alpha and beta proteins (a+b)LDH C-terminal domain-likeLDH C-terminal domain-likeLactate & malate dehydrogenases, C-terminal domainLactate dehydrogenaseHuman (Homo sapiens), muscle isoform (M chain) [TaxId: 9606]
359219 B:1-159Alpha and beta proteins (a/b)NAD(P)-binding Rossmann-fold domainsNAD(P)-binding Rossmann-fold domainsLDH N-terminal domain-likeLactate dehydrogenaseHuman (Homo sapiens), muscle isoform (M chain) [TaxId: 9606]
359220 B:160-331Alpha and beta proteins (a+b)LDH C-terminal domain-likeLDH C-terminal domain-likeLactate & malate dehydrogenases, C-terminal domainLactate dehydrogenaseHuman (Homo sapiens), muscle isoform (M chain) [TaxId: 9606]
359345 C:1-159Alpha and beta proteins (a/b)NAD(P)-binding Rossmann-fold domainsNAD(P)-binding Rossmann-fold domainsLDH N-terminal domain-likeLactate dehydrogenaseHuman (Homo sapiens), muscle isoform (M chain) [TaxId: 9606]
359346 C:160-331Alpha and beta proteins (a+b)LDH C-terminal domain-likeLDH C-terminal domain-likeLactate & malate dehydrogenases, C-terminal domainLactate dehydrogenaseHuman (Homo sapiens), muscle isoform (M chain) [TaxId: 9606]
359114 D:1-159Alpha and beta proteins (a/b)NAD(P)-binding Rossmann-fold domainsNAD(P)-binding Rossmann-fold domainsLDH N-terminal domain-likeLactate dehydrogenaseHuman (Homo sapiens), muscle isoform (M chain) [TaxId: 9606]
359115 D:160-331Alpha and beta proteins (a+b)LDH C-terminal domain-likeLDH C-terminal domain-likeLactate & malate dehydrogenases, C-terminal domainLactate dehydrogenaseHuman (Homo sapiens), muscle isoform (M chain) [TaxId: 9606]

CATH
CATH ID Node Class Architecture Topology Homology
6bb3A013.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain
6bb3A023.90.110.10:Alpha-Beta Complex:L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2:Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
6bb3B013.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain
6bb3B023.90.110.10:Alpha-Beta Complex:L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2:Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
6bb3C013.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain
6bb3C023.90.110.10:Alpha-Beta Complex:L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2:Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
6bb3D013.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain
6bb3D023.90.110.10:Alpha-Beta Complex:L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2:Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal