PDB ID : 6cge [A2]
Color
ARa IRb
|
|
a AR:All Residues
b IR:Interface Residues
b IR:Interface Residues
Slab plane
Title
CRYSTAL STRUCTURE OF HUMAN 17BETA-HSD TYPE 1 IN TERNARY COMPLEX WITH PBRM AND NADP+
Structure Summary
| PDB ID | Mutant | OPM | Pub Med | Method/Resolution | HETNAM |
|---|---|---|---|---|---|
| 6cge | 30148957 | X-RAY DIFFRACTION/2.2 | F0D:3-{[(14BETA,16ALPHA,17ALPHA)-3-(2-BROMOETHYL)-17-HYDROXYESTRA-1,3,5(10)-TRIEN-16-YL]METHYL}BENZAMIDE NAP:NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE |
| Chain Formula | ||
|---|---|---|
| Amino Acid sequence | SCOPe Family Level | CATH Homology Level |
| [A2] | [A2] | [A2] |
Interfaces
| Interface ID | Chain | Inaterface Class |
Interface Type | Contact Type |
|---|---|---|---|---|
| 6cge_AB | A B |
HEN HEN |
i15_CR(H38,E3,N23)_CE(H7,E1,N7)_HH(S5)_HE(S1)_HN(L3,S10)_EN(S1) i15_CR(H38,E3,N23)_CE(H7,E1,N7)_HH(S5)_HE(S1)_HN(L3,S10)_EN(S1) |
c2_RP(HH59,NN9,HE1,HN35,NE5,EH1,NH35,EN5)_HH(P2,A1,S12)_HE(S2)_HN(L7,S14)_EN(L2) c2_RP(HH59,NN9,HE1,HN35,NE5,EH1,NH35,EN5)_HH(P2,A1,S12)_HE(S2)_HN(L7,S14)_EN(L2) |
Interface Class
| Interface ID | Interface 1 | Interface 2 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Domain | Number of contact residues | Binding site Class | Percentages of Secondary structures(%) | Domain | Number of contact residues | Binding site Class | Percentages of Secondary structures(%) | |||||
| H | E | N | H | E | N | |||||||
| 6cge_AB | A | 60 | HEN | 61.7 | 100 | 35 | B | 60 | HEN | 63.3 | 3.3 | 33.3 |
Interface Type: Information for each interface
| Interface ID | chain | Number of contact residues | Number of elements | Number of contacts between Secondary structure elements | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HH | EE | HE | HN | EN | |||||||||||||||||||||
| Hn | En | Nn | H | E | N | R | L | P | A | S | P | A | S | Ph | Ah | Ih | P | A | S | L | S | L | S | ||
| 6cge_AB | A | 37 | 60 | 21 | 7 | 1 | 8 | 0 | 0 | 1 | 0 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 5 | 12 | 0 | 1 |
| 6cge_AB | B | 38 | 2 | 20 | 7 | 1 | 8 | 0 | 0 | 1 | 0 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 14 | 0 | 1 |
Contact Type: Information of contacts between interfaces
| Interface ID | Number of residue pairs between SS elements | Number of contacts between Secondary structure elements | ||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| H-H | E-E | N-N | H-E | H-N | N-E | E-H | N-H | E-N | H-H | E-E | H-E | H-N | E-N | |||||||||||||||
| P | A | S | Ih | P | A | S | IPh | IAh | P | A | S | Ih | L | S | Ih | L | S | Ih | ||||||||||
| 6cge_AB | 58 | 0 | 8 | 1 | 37 | 5 | 1 | 36 | 5 | 2 | 1 | 13 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 8 | 14 | 0 | 2 | 0 | 2 |
Structual Classification
SCOPe
| SCOPe ID | Chain | Class | Fold | Superfamily | Family | Protein Domain | Species |
|---|---|---|---|---|---|---|---|
| 362122 | A: | Alpha and beta proteins (a/b) | NAD(P)-binding Rossmann-fold domains | NAD(P)-binding Rossmann-fold domains | Tyrosine-dependent oxidoreductases | automated matches | Human (Homo sapiens) [TaxId: 9606] |
| 362075 | B: | Alpha and beta proteins (a/b) | NAD(P)-binding Rossmann-fold domains | NAD(P)-binding Rossmann-fold domains | Tyrosine-dependent oxidoreductases | automated matches | Human (Homo sapiens) [TaxId: 9606] |
CATH
| CATH ID | Node | Class | Architecture | Topology | Homology |
|---|---|---|---|---|---|
| 6cgeA00 | 3.40.50.720 | :3-Layer(aba) Sandwich | :Rossmann fold | :NAD(P)-binding Rossmann-like Domain | |
| 6cgeB00 | 3.40.50.720 | :3-Layer(aba) Sandwich | :Rossmann fold | :NAD(P)-binding Rossmann-like Domain |
