PDB ID : 6dtp [A2]

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ARa IRb





 a AR:All Residues
 b IR:Interface Residues

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Secondary Structure


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Chain
Chain name Ribbon Spacefill Cαonly
OLIGAMI PDB
AA
BB
Title
CRYSTAL STRUCTURE OF HUMAN 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 COMPLEXED WITH EM139

Structure Summary
PDB ID Mutant OPM Pub Med Method/Resolution HETNAM
6dtp
Not in PubMed X-RAY DIFFRACTION/2 EDO:1,2-ETHANEDIOL
EM9:N-BUTYL-11-[(7ALPHA,9BETA,13ALPHA,14BETA,16ALPHA,17ALPHA)-16-CHLORO-3,17-DIHYDROXYESTRA-1,3,5(10)-TRIEN-7-YL]-N-METHYLUNDECANAMIDE
GOL:GLYCEROL
PEG:DI(HYDROXYETHYL)ETHER
PGE:TRIETHYLENE GLYCOL
Chain Formula
Amino Acid sequence SCOPe Family Level CATH Homology Level
[A2] [A2] [A2]

Interfaces
Interface ID Chain Inaterface
Class		 Interface Type Contact Type
6dtp_AB A
B		 HEN
HEN		 i15_CR(H38,E3,N23)_CE(H7,E1,N7)_HH(S5)_HE(S1)_HN(L3,S10)_EN(S1)
i15_CR(H38,E3,N23)_CE(H7,E1,N7)_HH(S5)_HE(S1)_HN(L3,S10)_EN(S1) 		c2_RP(HH59,NN9,HE1,HN35,NE5,EH1,NH35,EN5)_HH(P2,A1,S12)_HE(S2)_HN(L7,S14)_EN(L2)
c2_RP(HH59,NN9,HE1,HN35,NE5,EH1,NH35,EN5)_HH(P2,A1,S12)_HE(S2)_HN(L7,S14)_EN(L2)

Interface Class
Interface ID Interface 1 Interface 2
Domain Number of contact residues Binding site Class Percentages of Secondary structures(%) Domain Number of contact residues Binding site Class Percentages of Secondary structures(%)
H E N H E N
6dtp_AB A 57 HEN 63.2 100 33.3 B 57 HEN 64.9 3.5 31.6

Interface Type: Information for each interface
Interface ID chain Number of contact residues Number of elements Number of contacts between Secondary structure elements
HH EE HE HN EN
Hn En Nn H E N R L P A S P A S Ph Ah Ih P A S L S L S
6dtp_AB A 36 57 19 7 1 8 0 0 0 0 6 0 0 0 0 0 0 0 0 1 4 13 0 1
6dtp_AB B 37 2 18 7 1 7 1 0 0 0 6 0 0 0 0 0 0 0 0 1 4 11 0 1

Contact Type: Information of contacts between interfaces
Interface ID Number of residue pairs between SS elements Number of contacts between Secondary structure elements
H-H E-E N-N H-E H-N N-E E-H N-H E-N H-H E-E H-E H-N E-N
P A S Ih P A S IPh IAh P A S Ih L S Ih L S Ih
6dtp_AB 59 0 9 1 33 5 1 32 5 2 1 13 0 0 0 0 0 0 0 0 2 0 6 13 0 2 0 2

Structual Classification
SCOPe
SCOPe ID Chain Class Fold Superfamily Family Protein Domain Species
357320 A:Alpha and beta proteins (a/b)NAD(P)-binding Rossmann-fold domainsNAD(P)-binding Rossmann-fold domainsTyrosine-dependent oxidoreductasesautomated matchesHuman (Homo sapiens) [TaxId: 9606]
357388 B:Alpha and beta proteins (a/b)NAD(P)-binding Rossmann-fold domainsNAD(P)-binding Rossmann-fold domainsTyrosine-dependent oxidoreductasesautomated matchesHuman (Homo sapiens) [TaxId: 9606]

CATH
CATH ID Node Class Architecture Topology Homology
6dtpA003.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain
6dtpB003.40.50.720:3-Layer(aba) Sandwich:Rossmann fold:NAD(P)-binding Rossmann-like Domain